Lipid rafts and membrane dynamics

Rajendran, Lawrence; Simons, Kai

doi:10.1242/jcs.01681

Cited by 527 publications

(461 citation statements)

References 38 publications

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“…131 Recently, lipid rafts have been demonstrated to be involved in control of apoptosis, particularly death receptor-mediated apoptosis. 132,133 Aplidine (Fig.…”

Section: Induction Of Death Receptor Redistribution and Clustering Bymentioning

confidence: 99%

Modulation of death receptors by cancer therapeutic agents

Elrod

Sun²

2008

Cancer Biology & Therapy

106

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“…131 Recently, lipid rafts have been demonstrated to be involved in control of apoptosis, particularly death receptor-mediated apoptosis. 132,133 Aplidine (Fig.…”

Section: Induction Of Death Receptor Redistribution and Clustering Bymentioning

confidence: 99%

Modulation of death receptors by cancer therapeutic agents

Elrod

Sun²

2008

Cancer Biology & Therapy

106

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“…Lipid-lipid immiscibility in cellular membranes imparts heterogeneity in the membrane plane and a subset of these lateral heterogeneities is termed lipid rafts (Rajendran and Simons, 2005). Lipid rafts are submicroscopic dynamic assemblies, which are more tightly packed than the surrounding liquid disordered regions (Simons and Vaz, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…The original raft concept proposed that the outer leaflet of the membrane contains lipid raft domains that are enriched in cholesterol and sphingolipids (Simons and Toomre, 2000), but recent evidence points to the existence of an equivalent domain organization in the inner leaflet as well (Rajendran and Simons, 2005). Several proteins have been shown to be partitioned into raft domains in both leaflets.…”

Section: Introductionmentioning

confidence: 99%

Raft association and lipid droplet targeting of flotillins are independent of caveolin

Rajendran

Lay

Illges

2007

Biological Chemistry

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Lipid rafts are liquid ordered platforms that dynamically compartmentalize membranes. Caveolins and flotillins constitute a group of proteins that are enriched in these domains. Caveolin-1 has been shown to be an essential component of caveolae. Flotillins were also discovered as an integral component of caveolae and have since been suggested to interact with caveolins. However, flotillins are also expressed in non-caveolae-containing cells such as lymphocytes and neuronal cells. Hence, a discrepancy exists in the literature regarding the caveolin dependence of flotillin expression and their subcellular localization. To address this controversy, we used mouse embryonic fibroblasts (MEFs) from caveolin-1 knockout (Cav-1 -/-) and wild-type mice to study flotillin expression and localization. Here we show that both membrane association and lipid raft partitioning of flotillins are not perturbed in Cav-1 -/-MEFs, whereas membrane targeting and raft partitioning of caveolin-2, another caveolin family protein, is severely impaired. Moreover, we demonstrate that flotillin-1, but not flotillin-2, associates with lipid droplets upon oleic acid treatment and that this association is completely independent of caveolin. Taken together, our results show that flotillins are localized in lipid rafts independent of caveolin-1 and that translocation of flotillin-1 to lipid droplets is a caveolin-independent process.

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“…It is widely believed that lipids and proteins on the cell membrane interact to form very small stable regions called rafts [1]. Usually in the size range of 10-200 nm, rafts are domains in the liquid-ordered phase, enriched by saturated lipids and cholesterol, and surrounded by the background cell membrane in the liquiddisordered phase [2].…”

Section: Introductionmentioning

confidence: 99%

“…They also coalesce to form larger regions that serve as platforms for cellular functions such as signalling, trafficking, endocytosis and immune responses [1,3,4]. Moreover, it has been shown that pathogens such as viruses use rafts as gateways during attacks on cells [1,[3][4][5]. Despite many experimental and theoretical investigations, a definitive understanding of the size, stability and lifetime of rafts remains elusive [2].…”

Section: Introductionmentioning

confidence: 99%

Multidomain and ground state configurations of two-phase vesicles

Maleki

Fried

2013

J. R. Soc. Interface.

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A simple model is used to study the equilibrium of lipid domains on two-phase vesicles. Two classes of configurations are considered: multidomain and ground state configurations. For multidomain configurations, the vesicle has a finite number of identical lipid domains. For ground state configurations, the vesicle is fully phase separated into two coexisting domains. Whereas the volume enclosed by a vesicle with multidomains is fixed, the volume enclosed by a vesicle in a ground state is allowed to vary with the osmotic pressure. Guided by experimental observations, all domains are assumed to be spherical caps. In a multidomain configuration, the line tension is found to decrease with the number of domains present, with possible exceptions when the number of domains is very small. The importance of a critical osmotic pressure and a critical excess radius on ground state configurations is explored. Emphasis is placed on understanding the variations of these critical quantities with relevant parameters.

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Lipid rafts and membrane dynamics

Cited by 527 publications

References 38 publications

Modulation of death receptors by cancer therapeutic agents

Modulation of death receptors by cancer therapeutic agents

Raft association and lipid droplet targeting of flotillins are independent of caveolin

Multidomain and ground state configurations of two-phase vesicles

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