Lipid raft idea is floated

How do sphingolipids and lipid rafts relate to pathology?

“…This happened before it was realized that these functions may be intimately linked to the physical properties of sphingolipids and, more specifically their organization in microdomains or rafts. These lipid rafts [2] have been implicated as both signaling platforms, and also as a means to traffic glycolipids and certain proteins to specific membranes of polarized cells. They are now thought to be involved in the entry into the cell of toxins, viruses and bacteria, play a role in protein (mis)processing in prion disease and Alzheimer's, and in the cellular immune response.…”