Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression

Ravacci, Graziela Rosa; Brentani, Maria Mitzi; Tortelli, Tharcísio Citrângulo; Torrinhas, Raquel Susana; Saldanha, Tatiana; Torres, Érica Miranda de; Waitzberg, Dan Linetzky

doi:10.1016/j.jnutbio.2012.02.001

Cited by 57 publications

(62 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, recent data found that u-3 PUFA promoted the formation of lipid rafts and inhibited the localization of signaling protein at the immunologic synapse [41]. These findings observed by either us or others are contradictory to those reported previously [42]. That study indicated that DHA treatment disrupted lipid raft.…”

Section: Discussioncontrasting

confidence: 64%

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Zhu

Tan

et al. 2015

Nutrition

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 64%

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Zhu

Tan

et al. 2015

Nutrition

View full text Add to dashboard Cite

“…2). Studies by Ghoreishi et al and S anchez-Lara et al assessed peripheral neuropathy, which has been reported to be a dose-limiting side effect of paclitaxel [13]. A lower incidence (P < 0,05) of peripheral neuropathy was observed for patients that consumed EPA and DHA omega-3 fatty acids [24,26].…”

Section: Resultsmentioning

confidence: 99%

Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review

2015

Self Cite

View full text Add to dashboard Cite

“…In MDA-MB-231 BC cells, several raft-associated proteins, including EGFR, Hsp90, Akt, and Src, are redistributed out of raft domains in response to DHA treatment [102], which induced increased BC cell apoptosis. Additionally, DHA was demonstrated to disrupt lipid rafts and reduce HER-2 signaling in mammary epithelial cells overexpressing HER-2 [104]. All of these proteins are involved in the regulation of cell survival and proliferation, and many are targets for cancer therapy.…”

Section: N-3 Pufa Lipid Rafts and Breast Cancermentioning

confidence: 99%

n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer

et al. 2014

View full text Add to dashboard Cite

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk of developing inflammation-associated cancer. Breast cancer is of particular interest given that increased inflammation within the subcutaneous mammary adipose tissue depot can alter the local tissue inflammatory microenvironment such that it resembles that of obese visceral adipose tissue. Therefore, in obese women with breast cancer, increased inflammatory mediators both locally and systemically can perpetuate inflammation-associated pro-carcinogenic signaling pathways, thereby increasing disease severity. Herein, we discuss some of these inflammation-associated pro-carcinogenic mechanisms of the combined obese breast cancer phenotype and offer evidence that dietary long chain n-3 polyunsaturated fatty acids (PUFA) may have utility in mitigating the severity of obesity-associated inflammation and breast cancer.

show abstract

Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression

Cited by 57 publications

References 47 publications

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Docosahexaenoic acid alters Gsα localization in lipid raft and potentiates adenylate cyclase

Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review

n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer

Contact Info

Product

Resources

About