2010
DOI: 10.1096/fasebj.24.1_supplement.lb26
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Lipid‐protein Interactions Studies in the αC418W Mutant Suffering from Slow Channel Congenital Myasthenic Syndrome

Abstract: Cholesterol is known to modulate membrane's biophysical properties and influence function and trafficking of membrane proteins. Cholesterol levels may regulate the movement of membrane proteins from functional to nonfunctional pools. To study this, the nicotinic acetylcholine receptor (nAChR) is used as a model due to its location on a functional pool and also, recent findings indicate that a nAChR mutation (αC418W) displayed an increase in macroscopic response upon cholesterol depletion. The αC418W is the fir… Show more

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