Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson’s disease

In an era where digital technology is pivotal, the integration of Information and Communication Technology (ICT) in education has become a focal point of research and discussion. This comprehensive literature review aims to bridge the gap in understanding the multifaceted impact of ICT on educational paradigms. The study delves into the transformative influence of ICT on teaching methodologies, the democratization of educational access, and the overall quality of learning experiences. Methodologically, this review synthesizes diverse academic sources, including empirical studies, theoretical frameworks, and case analyses. By integrating a broad spectrum of research findings, it provides a holistic view of the evolving educational landscape shaped by ICT. The study adopts a critical approach, weighing the advantages against the inherent challenges of ICT in education. The main findings reveal that ICT has revolutionized educational practices by introducing innovative teaching tools and methodologies. Digital platforms and resources have facilitated a more interactive, student-centered learning environment, enhancing engagement and comprehension. Moreover, ICT has played a crucial role in democratizing education, providing greater access to learning resources and opportunities, especially in underprivileged and remote areas. This aspect of ICT aligns with global educational equity goals, aiming to bridge the digital divide and create a more inclusive educational system. The review concludes that while ICT offers substantial benefits in reshaping education, a strategic and balanced approach is necessary. This approach should focus on mitigating digital inequality, ensuring continuous professional development for educators, and fostering an environment conducive to the effective integration of ICT. Future research directions include exploring the long-term impacts of ICT in education, particularly in developing countries, and examining the sustainability of technology-driven educational models.

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Parkinson’s Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model

Fonsêca

Gonçalves

Izidoro

et al. 2023

IJMS

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Parkinson’s-disease (PD) is an incurable, age-related neurodegenerative disease, and its global prevalence of disability and death has increased exponentially. Although motor symptoms are the characteristic manifestations of PD, the clinical spectrum also contains a wide variety of non-motor symptoms, which are the main cause of disability and determinants of the decrease in a patient’s quality of life. Noteworthy in this regard is the stress on the cardiac system that is often observed in the course of PD; however, its effects have not yet been adequately researched. Here, an untargeted metabolomics approach was used to assess changes in cardiac metabolism in the 6-hydroxydopamine model of PD. Beta-sitosterol, campesterol, cholesterol, monoacylglycerol, α-tocopherol, stearic acid, beta-glycerophosphoric acid, o-phosphoethanolamine, myo-inositol-1-phosphate, alanine, valine and allothreonine are the metabolites that significantly discriminate parkinsonian rats from sham counterparts. Upon analysis of the metabolic pathways with the aim of uncovering the main biological pathways involved in concentration patterns of cardiac metabolites, the biosynthesis of both phosphatidylethanolamine and phosphatidylcholine, the glucose-alanine cycle, glutathione metabolism and plasmalogen synthesis most adequately differentiated sham and parkinsonian rats. Our results reveal that both lipid and energy metabolism are particularly involved in changes in cardiac metabolism in PD. These results provide insight into cardiac metabolic signatures in PD and indicate potential targets for further investigation.

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Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson’s disease

Cited by 4 publications

References 77 publications

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Information and Communication Technology in the World of Education: A Theoretical and Empirical Overview – A Literature Review

Parkinson’s Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine Model

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