Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later

Manczak, Erika M.; Gotlib, Ian H.

doi:10.1177/0956797619885649

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…Furthermore, GO analysis showed that maternal obesity induced methylation changes that were mainly associated with metabolic process and cellular process, which are in accordance with previous study [ 35 ]. This agreement also confirms that newborns from overweight/obese pregnant women were heavier than those from the control group.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, in recent years, it is now known that umbilical cord blood can diagnose the physical and mental health of the fetus. In one of these studies, it was reported that babies with an anomalous lipid level profile at birth may face a higher risk of social and psychological problems in childhood [ 35 ]. Therefore, cord blood testing can be employed to predict the psychological development of children.…”

Section: Discussionmentioning

confidence: 99%

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Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood

Wang

Quan

et al. 2022

Hum Genomics

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Background Over the past few decades, global maternal obesity prevalence has rapidly increased. This condition may induce long-lasting pathophysiological effects on either fetal or infant health that could be attributable to unknown unique changes in the umbilical blood composition. Methods A total of 34 overweight/obese and 32 normal-weight pregnant women were recruited. Fifteen umbilical blood samples including 8 overweight/obese subjects and 7 normal weight women were sequenced using Targeted Bisulfite Sequencing technology to detect the average methylation level of cytosine and identify the differentially methylated region (DMR). GO and KEGG analyses were then employed to perform pathway enrichment analysis of DMR-related genes and promoters. Moreover, the mRNA levels of methylation-related genes histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) were characterized in the samples obtained from these two groups. Results Average methylated cytosine levels in both the CpG islands (CGI) and promoter significantly decreased in overweight/obese groups. A total of 1669 DMRs exhibited differences in their DNA methylation status between the overweight/obese and control groups. GO and KEGG analyses revealed that DMR-related genes and promoters were enriched in the metabolism, cancer and cardiomyopathy signaling pathways. Furthermore, the HDACs and DNMTs mRNA levels trended to decline in overweight/obese groups. Conclusions Decreased methylated cytosine levels in overweight/obese women induce the gene expression activity at a higher level than in the control group. DMRs between these two groups in the fetal blood may contribute to the changes in gene transcription that underlie the increased risk of metabolic disorders, cancers and cardiomyopathy in their offspring.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood

Wang

Quan

et al. 2022

Hum Genomics

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“…Elevated TG levels at birth have been significantly linked with children’s psychological and social functioning 5 years later, suggesting that fetal exposure to lipids may represent a novel form of biological embedding for psychological health risk (Manczak & Gotlib, 2019 ). Moreover, increased levels of TGs with saturated or monounsaturated fatty acyls we observed in our study have been linked with non-alcoholic fatty liver disease (NAFLD) as well as insulin resistance in adults (Oresic et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood

et al. 2021

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Introduction Poly-/per-fluoroalkyl substances (PFAS) are widespread environmental pollutants that may induce metabolic perturbations in humans, including particularly alterations in lipid profiles. Prenatal exposure to PFAS can cause lasting effects on offspring metabolic health, however, the underlying mechanisms are still unknown. Objectives The goal of the study was to investigate the impact of prenatal PFAS exposure on the lipid profiles in cord blood. Methods Herein, we combined determination of bile acids (BAs) and molecular lipids by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified cord blood concentrations of sixteen PFAS in a cohort of Chinese infants (104 subjects) in a cross-sectional study. We then evaluated associations between PFAS concentration and lipidome using partial correlation network analysis, debiased sparse partial correlation, linear regression analysis and correlation analysis. Results PFAS levels showed significant associations with the lipid profiles; specifically, PFAS exposure was positively correlated with triacylgycerols (TG) and several bile acids. Importantly, exposure to perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA) and perfluorohexane sulfonic acid (PFHxS) were associated with increased levels of TGs with saturated fatty acids while multiple classes of phospholipids were decreased. In addition, several free fatty acids showed significant positive correlations with PFOS. Conclusions Our results indicated that prenatal exposure to PFAS mediated metabolic changes, which may explain the associations reported between PFAS exposure and metabolic health later in life.

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“…141 In addition, longitudinal studies have found that associations of cholesterol levels between birth and adolescence are associated with the later development of depressive symptoms. [142][143][144]…”

Section: N Kappelmann Et Almentioning

confidence: 99%

Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis

Kappelmann

Perry

Khandaker

2022

Harv Rev Psychiatry

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Depression and psychosis have a developmental component to their origin. Epidemiologic evidence, which we synthesize in this nonsystematic review, suggests that early-life infection, inflammation, and metabolic alterations could play a role in the etiology of these psychiatric disorders. The risk of depression and psychosis is associated with prenatal maternal and childhood infections, which could be mediated by impaired neurodevelopment. Evidence suggests linear dose-response associations between elevated concentrations of circulating inflammatory markers in childhood, particularly the inflammatory cytokine interleukin 6, and the risk for depression and psychosis subsequently in early adulthood. Childhood inflammatory markers are also associated with persistence of depressive symptoms subsequently in adolescence and early adulthood. Developmental trajectories reflecting persistently high insulin levels during childhood and adolescence are associated with a higher risk of psychosis in adulthood, whereas increased adiposity during and after puberty is associated with the risk of depression. Together, these findings suggest that higher levels of infection, inflammation, and metabolic alterations commonly seen in people with depression and psychosis could be a cause for, rather than simply a consequence of, these disorders. Therefore, early-life immuno-metabolic alterations, as well as factors influencing these alterations such as adversity or maltreatment, could represent targets for prevention of these psychiatric disorders. Inflammation could also be an important treatment target for depression and psychosis. The field requires further research to examine sensitive periods when exposure to such immuno-metabolic alterations is most harmful. Interventional studies are also needed to test the potential usefulness of targeting early-life immuno-metabolic alterations for preventing adult depression and psychosis.

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Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later

Cited by 7 publications

References 38 publications

Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood

Maternal obesity alters methylation level of cytosine in CpG island for epigenetic inheritance in fetal umbilical cord blood

Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood

Prenatal and Childhood Immuno-Metabolic Risk Factors for Adult Depression and Psychosis

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