Lipid Profiles and Framingham Risk Score in Patients with Coronary Artery Bypass Graft Surgery undergoing Cardiac Rehabilitation Program

Abstract

Coronary artery disease (CAD) is one of the major predictors of future cardiovascular events (CVEs). In addition, biomarkers such as high-sensitivity C-Reactive Protein (hsCRP), fibrinogen, homocysteine, and free fatty acid (FFA) correlate well with a future CVE. The Framingham Risk Score is a gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual. Cardiac rehabilitation is an instrument of medical management in cardiovascular diseases; beyond prevention, it can improve heart and muscle functioning in patients that were undergoing CABG, and cardiac and vascular adaptation. Over a 2-year period, 120 subjects were randomized and comprehensively evaluated. The mean age of the patients under study was 65.70 � 9.91 years old. For the Framingham cardiovascular risk score, the mean value in the Phase I was 16.5, while the mean value in Phase III was 10.6. The difference registered after cardiac surgery and the value in 6 months after the onset of cardiac rehabilitation program was important and statistically significant, as p [ 0.05. Fibrinogen showed significant phase-to-phase reductions of plasmatic values. Lipid profile values showed a statistically significant decrease. The renal filtration function evaluated by plasma creatinine showed statistically significant improvement and, in terms of absolute values, creatinine level was reduced in a range between 0.2-0.4 mg/dL. Also, it was recorded a significantly lower level of blood urea. By comparing the Phase I and Phase III results, we observed that the median 10-year Framingham cardiovascular risk score was approximately 6% lower (p [0.05), reflecting the survival benefit gained by patients under the intensive cardiovascular recovery program.

Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

“…Lipid profile values showed a statistically significant decrease, although, in those whose initial value exceeded the normality limit, the reduction did not bring the patient back to low cardiovascular risk range, as we have shown in a previous study (10).…”

“…The effects of cardiac recovery program in patients who have had a heart surgery can be seen in reducing complications, improving QoL, lowering mortality rate at 10 years. The high educational level of our patients may have influenced the great outcomes of the complex management and sustained it, ensuring a long-time compliance of the patients to the new lifestyle, regimen, treatment and follow-up control [10,11].…”

Seroprevalence of HGV among blood donors with HCV and / or HBV in Tikrit City

“…The present data revealed that anti-HGV antibodies were found in 27.2% of blood donors with HCV and 3.84 % of those with HBV. A study was performed in Kirkuk City revealed that no one of blood donors with HCV had anti-HGV antibodies (11). In Saudi Arabia, the co-infection rate of HGV was 31% in patients with HCV infection (12).…”

Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?

“…A diet high in saturated fat, hypercholesterolemia, obesity, dyslipidaemia, hyperglycemia, insulin resistance, hypertension, dysfunction of nitric oxide, and smoking habit are key players in atherosclerosis occurrence [13,14]. All these factors are also actively involved in the development of major cardiovascular diseases (coronary diseases, stroke, heart failure, peripheral vascular disease) [15,16].The aim of this study was to investigate of the impact of some risk factors for atherosclerosis on the antiplatelet effect of clopidogrel in patients with acute coronary syndrome and the possible correlation with metabolizer phenotype of patients based on CYP2C19 polymorfisms.…”