Lipid Profile of Children with Malaria byPlasmodium vivax

Abstract

Background. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed to P. vivax. Objective. To evaluate lipid abnormalities in children with P. vivax infection and to assess if parasite count or the history of malaria correlates with lipid levels at admission. Methods. A total of 75 children were included in the study, from which 43 were slide confirmed infection by P. vivax. Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Results. The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients. Conclusion. There are significant lipid abnormalities in children with low level of P. vivax infection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.

Preclinical Trial of Traditional Plant Remedies for the Treatment of Complications of Gestational Malaria

“…The lipid profile of the malarous dams implied that severe hypercholesterolemia was a consequence of untreated gestational malaria and the hypercholesterolemic effect persisted even after chloroquine treatment. In agreement with our finding, earlier studies established that patients with malaria present clinical conditions, such as hypocholesterolemia, hypertriglyceridemia, and low levels of high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs) [39]. Hence, the therapeutic efficacy of the antimalarial herbs decreased the susceptibility of the malarous pregnant rats' to cardiovascular dysfunction.…”

Liver enzymes and lipid profile of malaria patients before and after antimalarial drug treatment at Dembia Primary Hospital and Teda Health Center, Northwest, Ethiopia

“…Total cholesterol and LDL levels of the study participants were within the normal reference ranges (<100 and <200), respectively, before antimalarial treatment was administered. The finding of the present study agreed with a previous study finding conducted in Ethiopia where LDL (34.7±23.5) and TC(88.0±36.3) levels were reported (36) and a similar result from India reported a value of LDL(70.45±22.720) and TC(103.52±35), respectively (33).On the other hand, our study findings are lower than the study conducted in Brazil where TG (55.8%),HDL (92.8%), and LDL (97.6%) levels were reported (37). The possible explanation of the difference in liver enzymes and lipid profiles could be due to the utilization of different cutoff values, malaria species, or the difference of study participants in sociodemographic characteristics such as age and genetic variation.…”

Methanol extracts of Fagara zanthoxyloides leaves possess antimalarial effects and normalizes haematological and biochemical status of Plasmodium berghei-passaged mice

“…In children with malaria by P. vivax , Dias et al. (2016) reported significantly lower levels of total cholesterol, LDL, and HDL, and significantly higher levels of VLDL and TAG. Dungdung et al.…”