Lipid profile of children and adolescents with type 1 diabetes mellitus

Abstract

INTRODUCTION: Cardiovascular diseases are the main cause of death in patients with type 1 diabetes mellitus (T1DM) and atherosclerotic process begins in childhood. OBJECTIVE: To evaluate lipid profile of patients with T1DM accompanied at the pediatric endocrinology (UEP), Hospital de Clínicas, Federal University of Paraná (HC-UFPR), the prevalence of dyslipidemia and its correlation with glycemic control, duration of T1DM, family history of dyslipidemia and nutritional profile status. METHODS: Data of diagnostic information, comorbidities, birth weight, sex, family history of diabetes, dyslipidemia and heart diseases were reviewed. Anthropometric measurements, glycemic control, blood pressure (BP), lipid profile, and pharmacological treatment for dyslipidemia were obtained in four moments: after three months of diagnosis (t1), two (t2), five (t3), and ten (t4) years of illness. RESULTS: 228 patients (122 girls), mean age at diagnosis of 7.3 years, were included. In t3 and t4 there was a significant increase in BP elevation. Prevalence of dyslipidemia was 31.7% in t1, 33.7% in t2; 37.4% in t3; and in 63.6% in t4. There was a significant increase in total cholesterol and LDL-cholesterol level over time (p<0.001) and a significant increase in triglycerides levels only in t4 (p=0.002). CONCLUSION: Changes in lipid profile in children and adolescents with T1DM are prevalent, but they are undertreated, and the greater age, the greater probability of developing dyslipidemia. Thus, screening for dyslipidemia should be done and pharmacological treatment should be encouraged as recommended.

Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study

“…Several studies with individuals with T1DM have evaluated the the prevalence of dyslipidemia and the duration of the disease. A pre found in patients with up to five years of diagnosis and 53.6% in pa years of diagnosis of T1DM [59]. Other studies have shown a pre indicates a significant effect of the model for p-value ≤ 0.050.…”

“…Several studies with individuals with T1DM have evaluated the relationship between the prevalence of dyslipidemia and the duration of the disease. A prevalence of 37.1% was found in patients with up to five years of diagnosis and 53.6% in patients with up to ten years of diagnosis of T1DM [ 59 ]. Other studies have shown a prevalence of 26.2% in patients diagnosed with T1DM for 5.6 years [ 60 ] and 72.5% in patients with the disease for 10.6 years [ 61 ].…”

“…The high prevalence of dyslipidemia in children and a in our study (65.4%) is similar to the ones documented i analyzed the same population and used the same diagnostic off points adopted and the clinical aspects of glycemic con sex, PAL, and body composition [42,43,56]. When usin diagnostic criteria for dyslipidemia, the prevalence found w Several studies with individuals with T1DM have evalu the prevalence of dyslipidemia and the duration of the disea found in patients with up to five years of diagnosis and 53. years of diagnosis of T1DM [59] (estimate of the percentage of variation in the depe variation in the independent variables included in the model). p-val effect.…”