Lipid profile evaluation and severe hypercholesterolaemia screening in the middle-aged population according to nationwide primary prevention programme in Lithuania

Kutkienė, S.; Petrulionienė, Ž.; Laucevičius, Aleksandras; Čerkauskienė, Rimantė; Staigyte, J.; Saulyte, Akvile; Petrulionyte, E.; Gargalskaitė, U.; Skiauteryte, E.; Matuzeviciene, Gabija; Kovaite, M.; Rinkūnienė, E.

doi:10.1016/j.atherosclerosis.2018.06.008

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…The covariates are as follows: age of onset, sex, BMI, glucose level, TC, TG, LDL, HDL, AQP4 status, initial EDSS, autoimmune diseases, hypertension, diabetes, therapeutic regimens (including steroids, immunosuppressive therapy, rehabilitation training, and statin treatment), and relapses. Interaction and stratified analysis were employed to examine the association between TG level and the outcomes according to variables mentioned above and continuous data were grouped into dichotomous variables, including age (≤ 60 and > 60 year), BMI (≤ 25 and > 25 kg/m 2 ) (16), TC (≤ 5.0 and > 5.0 mmol/L), HDL (≤ 1.0 and > 1.0 mmol/L), LDL (≤ 3.0 and > 3.0 mmol/L) (17), Glucose (≤ 6.1 and > 6.1 mmol/L) (18), and Initial EDSS (≤ 3 and > 3). For multivariate logistic regression, we adjusted multiple confounders to analyze the stability of the associations between TG level and outcomes.…”

Section: Methodsmentioning

confidence: 99%

Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients

Wen

Duan

et al. 2019

Front. Neurol.

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Objective: To investigate prospective associations between triglyceride (TG) level and prognosis of first-attacked patients with neuromyelitis optica spectrum disorders (NMOSD).Methods: This retrospective study included 196 patients newly diagnosed with NMOSD from June 2014 to December 2018. Data of clinical parameters, including age of onset, sex, BMI, blood lipid levels, anti-aquaporin-4 status, serum glucose level, therapy regimens, comorbidities, initial Expanded Disability Status Scale (EDSS), relapses, and outcomes were collected. We used logistic regression models to examine the associations among relevant clinical factors and outcomes, and statistical analyses were performed using the SPSS 23.0 software.Results: Compared with the high TG group, residual EDSS was relatively lower in the normal TG group (median 1.0 vs. 2.0, P = 0.002). In the univariate analysis, TG level was positively correlated with outcomes (OR 1.75, 95% CI 1.18–2.60, P = 0.005) and relapses (OR 1.57, 95% CI 1.07–2.31, P = 0.02). Our stratified analysis suggested that patients with normal BMI (OR 4.90, 95% CI 2.10–11.44, P = 0.001) were closely correlated with poor recovery owing to increased TG level. In the multivariate analysis, a statistically significant association still existed between TG level and outcomes (OR 3.44, 95% CI 1.02–11.64; P = 0.040) after adjusting for various variables.Conclusions: In first-attacked NMOSD patients, TG level was positively associated with poor recovery. Early monitoring and treatment of elevated TG level in NMOSD patients are important.

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Section: Methodsmentioning

confidence: 99%

Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients

Wen

Duan

et al. 2019

Front. Neurol.

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“…We excluded 89 articles which were duplicate studies (n=1); performed before the year 2000 (n=9); had absence of full text or lack of sufficient data for extraction (n=22); had the presence of known diabetes, pre-diabetes or CVD (n=44); or target population whose subjects reported family history of diabetes, pre-diabetes or elevated BMI (n=13). Finally, we included 38 studies from 33 articles in the present systematic review 27–59…”

Section: Resultsmentioning

confidence: 99%

“…A total of four studies offered lipid screening33 34 51 57: one cross-sectional screening survey was covered by research funding,57 one study was workplace-based screening and insured by employers33 and the other two studies were for national screening programmes supported by government organisations 34 51. Only one study was from a developed country33 (table 1).…”

Section: Resultsmentioning

confidence: 99%

Characteristics of participants who take up screening tests for diabetes and lipid disorders: a systematic review

et al. 2022

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ObjectivesTo perform a systematic review on the characteristics of participants who attended screening programmes with blood glucose tests, lipid profiles or a combination of them, respectively.DesignSystematic review following the Meta-analysis Of Observational Studies in Epidemiology checklist.Data sourcesPubMed and Medline databases for English literature from 1 January 2000 to 1 April 2020.Eligibility criteriaOriginal observational studies that reported baseline characteristics of apparently healthy adult participants screening for diabetes and lipid disorders were included in this review.Data extractionWe examined their sociodemographic characteristics, including age, gender, body mass index (BMI) and lifestyle habits. The quality of the included articles was evaluated by the Appraisal of Cross-sectional Studies.ResultsA total of 33 articles involving 38 studies in 22 countries were included and analysed in this systematic review. Overall, there was a higher participation rate among subjects who were female in all screening modalities (female vs male: 46.6%–63.9% vs 36.1%–53.4% for diabetes screening; 48.8%–58.4% vs 41.6%–51.2% for lipid screening; and 36.4%–76.8% vs 23.2%–63.6% for screening offering both). Compared with the BMI standard from the WHO, participants in lipid screening had lower BMI (male: 23.8 kg/m2 vs 24.2 kg/m2, p<0.01; female: 22.3 kg/m2 vs 23.6 kg/m2, p<0.01). Furthermore, it is less likely for individuals of lower socioeconomic status to participate in diabetes or lipid screening in developed areas.ConclusionsWe identified that individuals from lower socioeconomic groups were less likely to take up programmes for diabetes and/or lipid screening in developed areas. These populations are also likely to be at higher risk of non-communicable diseases. Future studies should investigate the barriers and facilitators of screening among non-participants, where targeted interventions to enhance their screening uptake are warranted.

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“…Therefore, each new report is of great importance. It is especially true for CEE countries, including Poland, and based on our best knowledge it is only the second real-life report on FH population [ 43 ] and one of several from this region [ 22 , 44 ]. Moreover, there are large differences in the diagnosis, effectiveness of therapy, and monitoring of FH patients in different regions of the world, and such papers give possibility to compare these outcomes.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Familial Hypercholesterolemia in Children and Adults in EAS-FHSC Regional Center for Rare Diseases in Poland

Lewek

Konopka

Starostecka

et al. 2021

JCM

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Background: Familial hypercholesterolemia (FH) is a genetic autosomal co-dominant metabolic disorder leading to elevated circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Early development of atherosclerotic cardiovascular disease (ASCVD) is common in affected patients. We aimed to evaluate the characteristics and differences in the diagnosis and therapy of FH children and adults. Methods: All consecutive patients who were diagnosed with FH, both phenotypically and with genetic tests, were included in this analysis. All patients are a part of the European Atherosclerosis Society FH-Study Collaboration (FHSC) regional center for rare diseases at the Polish Mother’s Memorial Hospital Research Institute (PMMHRI) in Lodz, Poland. Results: Of 103 patients with FH, there were 16 children (15.5%) at mean age of 9 ± 3 years and 87 adults aged 41 ± 16; 59% were female. Children presented higher mean levels of total cholesterol, LDL-C, and high-density lipoprotein cholesterol (HDL-C) measured at the baseline visit (TC 313 vs. 259 mg/dL (8.0 vs. 6.6 mmol/L), p = 0.04; LDL 247 vs. 192 mg/dL (6.3 vs. 4.9 mmol/L), p = 0.02, HDL 53 vs. 48 mg/dL (1.3 vs. 1.2 mmol/L), p = 0.009). Overall, 70% of adult patients and 56% of children were prescribed statins (rosuvastatin or atorvastatin) on admission. Combination therapy (dual or triple) was administered for 24% of adult patients. Furthermore, 13.6% of adult patients and 19% of children reported side effects of statin therapy; most of them complained of muscle pain. Only 50% of adult patients on combination therapy achieved their treatment goals. None of children achieved the treatment goal. Conclusions: Despite a younger age of FH diagnosis, children presented with higher mean levels of LDL-C than adults. There are still urgent unmet needs concerning effective lipid-lowering therapy in FH patients, especially the need for greater use of combination therapy, which may allow LDL-C targets to be met in most of the patients.

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Lipid profile evaluation and severe hypercholesterolaemia screening in the middle-aged population according to nationwide primary prevention programme in Lithuania

Cited by 6 publications

References 25 publications

Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients

Triglyceride Level Is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients

Characteristics of participants who take up screening tests for diabetes and lipid disorders: a systematic review

Clinical Features of Familial Hypercholesterolemia in Children and Adults in EAS-FHSC Regional Center for Rare Diseases in Poland

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