Lipid profile comparison of tomato extract and atorvastatin supplementation in atherosclerosis rats

Abstract

The use of synthetic drugs, such as atorvastatin and simvastatin, often cause health problems caused by side effects. Tomatoes are a food source that contains antioxidants such as vitamins A, C and E in high amounts and increase because of the processing. The nutritional content of tomatoes in preventing hypercholesterolemia arising from oxidative stress as a result of accumulation of LDL-cholesterol in the endothelium. Therefore, this study considers steamed tomatoes in overcoming the condition of hypercholesterolemia. The study design uses the Post Test Randomized Control Group Design. Before being given as many as 24 white rats that were made hypercholesterolemia, then divided into 4 groups, namely K1 (negative control group), K2 (atherosclerosis rat control group), K3 (atherosclerosis group called atorvastatin), K4 (atherosclerosis group supplemented with 16 mg / tail / day). ANOVA-LSD test results showed the differences shown (p <0.05) between the control group (K) and the consultation group (K3 and K4).