Lipid Profile and Oxidative Stress Markers in Wistar Rats following Oral and Repeated Exposure to Fijk Herbal Mixture

Adeyemi, Oluyomi Stephen; Orekoya, Bukola Temitope

doi:10.1155/2014/876035

Cited by 19 publications

(13 citation statements)

References 15 publications

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“…In like manner, the present study showed that arsenite exposure has capacity to predispose rats to cardiovascular disorder by increasing plasma total CHOL, LDL-C, while lowering the HDL-C levels which raised the atherogenic index. Elevated atherogenic index has been associated with the development of atherosclerosis (Olukanni et al 2013;Adeyemi and Orekoya 2014). Our findings agree with studies that have linked arsenic toxicity to cardiovascular disorders (Straub et al 2008;Das et al 2012;Kumar et al 2014).…”

Section: Discussionsupporting

confidence: 90%

“…Arsenic exposure in rats significantly reduced the rat liver weight as well as the liver-to-body weight ratio. This may indicate ensuing adverse effect by arsenite as studies have associated changes to body or organ weights with chemical or drug intoxication (Adeyemi and Orekoya 2014;Sulaiman et al 2015). This is consistent with other studies have demonstrated arsenic-induced changes to rat body or organ weights (Aliyu et al 2012;Chandraayagam et al 2013).…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Adeyemi

Meyakno²,

Akanji³

2017

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Study determined the influence of the inhibition of Kupffer cell functions by GdCl3 in arsenic intoxication. Twenty-four Wistar rats weighing between 150 and 160 g were randomly assigned into four groups. Group 1 received sodium arsenite (1.5 mg/kg b.w.) once a day, Group 2 received GdCl3 (2 mg/kg b.w.) once, 24 hours before commencing the arsenite (1.5 mg/kg b.w.) treatment. Group 3 received GdCl3 (2 mg/kg b.w.) once and subsequently given distilled water. Group 4 received distilled water only. The treatments were daily by oral gavage and lasted for 28 days. Animals were euthanized 24 hours after the last treatment. Arsenic exposure elevated the activities of rat plasma AST, ALT, ALP and γ-GT, indicative of liver injury. Arsenic exposure in rat lowered GSH concentration but potentiated inflammation and oxidative stress evidenced in the raised levels of MPO, NO and MDA. Rats with arsenic exposure were predisposed to atherosclerosis, lowering the HDL-C but elevated the LDL-C concentration. The histopathological assessment showed degenerating cellular lesion caused by arsenic. However, the inhibition of Kupffer cell functions by GdCl3 suppressed arsenic intoxication improving the liver function indices, oxidative stress status, lipid profile, neutrophilic inflammation and ultimately restored the cellular architecture. Data suggest that specific inhibition of Kupffer cells by GdCl3 protected against arsenic intoxication.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Adeyemi

Meyakno²,

Akanji³

2017

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“…Earlier studies showed that change to body or organ weights after chemical exposure may indicate toxicity[28–29]. In the present study, Ni exposure caused rat weight loss as well as alterations in vital organ weights in manners that may suggest ensuing adverse effect.…”

Section: Discussionsupporting

confidence: 58%

Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats

2017

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Multiple health-promoting effects have been attributed to the consumption of Moringa oleifera leaves, as part of diet without adequate scientific credence. This study evaluated the effect of M. oleifera-based diets on nickel (Ni) - induced hepatotoxicity in rats. Male rats assigned into six groups were given oral administration of 20 mg/kg body weight nickel sulfate in normal saline and either fed normal diet orM. oleifera-based diets for 21 days. All animals were sacrificed under anesthesia 24 hours after the last treatment. Ni exposure elevated the rat plasma activities of alanine transaminase, aspartate transaminase and alkaline phosphatase significantly. Ni exposure also raised the levels of triglyceride, total cholesterol and low-density lipoprotein cholesterol while depleting the high-density lipoprotein cholesterol concentration. Further, Ni exposure raised rat plasma malondialdehyde but depleted reduced glutathione concentrations. The histopathological presentations revealed inflammation and cellular degeneration caused by Ni exposure. We show evidence thatM. oleifera-based diets protected against Ni-induced hepatotoxicity by improving the rat liver function indices, lipid profile as well as restoring cellular architecture and integrity. Study lends credence to the health-promoting value ofM. oleifera as well as underscores its potential to attenuate hepatic injury.

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“…This is further supported by the plasma AST/ALT ratio of less than one (AST/ALT <1) which may indicate ensuing acute or chronic liver injury (Essani et al, 1995). This could be due the fact that cellular enzymes extrude into the extracellular fluid, thus raising their concentrations in plasma (Adeyemi and Bukola, 2014) due to hepatocellular damage, hence the rise in their plasma levels. The significant decrease in AST and ALT observed in groups C and D when compared with group B may be attributed to the antioxidative or the hepatoprotective effect of leaves aqueous extract of A. indica which is similar to documented reports on the hepatoprotective activity of A. indica (Ha et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Vitamins C and E levels are enhanced by Azadirachta Indica leaves aqueous extract in paracetamol induced hepatoxicity in Wistar rats

Nwobodo¹,

Nwosu²,

Nwanjo³

et al. 2016

J. Med. Plants Res.

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Azadirachta indica, used in many parts of the world as herbal medicine, has been reported to be antioxidative and hepatoprotective. This study investigated the effect of leaves aqueous extract of A. indica on plasma levels of vitamins C and E, liver enzymes alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) in Wistar rats with hepatotoxicity. Four groups of twenty Wistar rats each was used. Group A was given normal saline, group B 800 mg/kg body weight of paracetamol, group C 800 mg/kg body weight paracetamol and 400 mg/kg body weight of leaves extract of A. indica and group D 800 mg/kg body weight paracetamol and 1000 mg/kg of leaves extract of A. indica. The animals were weighed before and after the experiment and the levels of ALT, AST, ALP and vitamins C and E were estimated. There were significant differences between the initial and final mean weights of the animals (ρ<0.05). Plasma liver enzymes were significantly increased in group B, while these enzymes were significantly decreased in group D when compared with B (ρ< 0.05). There was no change in ALP levels (ρ>0.05). Vitamins C and E in liver homogenate were decreased in group B and increased in group D (ρ<0.05) while group C showed no change (ρ>0.05). Vitamins C and E were decreased in group B and increased in group D (ρ<0.05). The observed decrease in liver enzymes and increase in vitamins C and E in group D suggest that the extract enhances vitamins C and E levels, and may be hepatoprotective.

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Lipid Profile and Oxidative Stress Markers in Wistar Rats following Oral and Repeated Exposure to Fijk Herbal Mixture

Cited by 19 publications

References 15 publications

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats

Vitamins C and E levels are enhanced by Azadirachta Indica leaves aqueous extract in paracetamol induced hepatoxicity in Wistar rats

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