Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders

Saleh, Afaf Abbass Sayed

doi:10.1016/j.jobaz.2015.01.001

Cited by 16 publications

(16 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with a previous study by Saleh [35] that documented a strong relationship between the serum Hcy levels and lipid concentrations especially the concentrations of cholesterol in hypothyroid rats. Conversely, several other investigations demonstrated that Hcy was nonsignificantly correlated with the TC level in overt hypothyroid patients ( r = 0.288, P = 0.12).…”

Section: Discussionsupporting

confidence: 94%

Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism

Dong

Yao²,

Hu³

et al. 2016

Medicine

View full text Add to dashboard Cite

Objective:Hypothyroidism (HO) can induce metabolic dysfunctions related to insulin resistance and dyslipidemia. Our previous studies showed that homocysteine (Hcy) impaired the coronary endothelial function and that Hcy can promote chemokine expression and insulin resistance (IR) by inducing endoplasmic reticulum stress in human adipose tissue and hypothyroid patients. The aim of this study was to investigate the potential harmful correlation between plasma Hcy and low-density lipoprotein cholesterol (LDL-C) in patients with HO.Methods:A total of 286 subjects were enrolled. All subjects were divided into the following 3 groups: HO group, subclinical hypothyroidism (SHO) group, and control group. Statistical analyses were carried out to evaluate the correlation between the plasma levels of Hcy and LDL-C in HO patients. The changes in the plasma Hcy levels and other metabolic parameters were measured before and after levothyroxine (L-T4) treatment. The relationship between the changes in the plasma Hcy level and the LDL-C level was also evaluated after L-T4 treatment.Results:In the patients with HO, both the plasma Hcy and LDL-C levels were significantly higher than those of the controls. The plasma levels of Hcy were positively correlated with the LDL-C level in the HO group. L-T4 treatment resulted in a significant decrease in the BMI, total cholesterol (TC), LDL-C, triglycerides (TG), apolipoprotein B (ApoB), and Hcy levels. Moreover, the decrease in Hcy (ΔHcy) was positively correlated with decreased LDL-C (ΔLDL-C) levels after L-T4 treatment in HO patients.Conclusion:Our results suggest that the increased Hcy level was positively correlated with the LDL-C in the HO group. A potential harmful interaction may exist between Hcy and LDL-C under the HO condition. In addition to reducing the plasma levels of Hcy, L-T4 treatment exerts beneficial effects on patients with HO by improving dyslipidemia, including a decrease in the LDL-C level.

show abstract

Section: Discussionsupporting

confidence: 94%

Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism

Dong

Yao²,

Hu³

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…In adults, increasing levels of TSH to be associated with increases in TC, LDL-C and TG and with decreases in HDL-C [71]. Moreover, [72] reported that, there was a significant (P< 0.05) elevation in serum levels of lipid profile (TC, TG and LDL-C) in rats with hypothyroidism. Thyroid function regulates some metabolic parameters as lipoprotein metabolism (so any disturbance in thyroid hormones leads to dyslipidemia) and some cardiovascular disease risk factors [73,74].…”

Section: Resultsmentioning

confidence: 97%

“…Excess production of thyroid hormones leads to hyperthyroidism while diminished production leads to hypothyroidism [4]. Thyroid disease, constitutes the most common endocrine abnormality in recent years, diagnosed either in subclinical or clinical form and is associated with various metabolic abnormalities, due to the effects of thyroid hormones on nearly all major metabolic pathways [5], increasing the basal metabolic rate, affecting protein synthesis, regulating the metabolism of protein, lipids and carbohydrates [6] and involved in the regulation of oxidative metabolism [7]. They can cause many changes in the number and activity of mitochondrial respiratory chain components.…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Rabeh¹,

El-Ghandour²

2016

IJNFS

View full text Add to dashboard Cite

Abstract:The aim of the study was to investigate the effect of Iron, Zinc, Vitamin C (Vit.C) and Vitamin E (Vit.E) supplementation on thyroid hormones in rats with hypothyroidism. Thirty six rats were divided into two main groups, the first main group (6 rats) was fed on basal diet only. The second main group (30 rat) were injected with 10 mg/kg/day Propylthiouracil (PTU) to induce hypothyroidism, was divided into 5 subgroups: including control positive group that fed on basal diet, and the other subgroups were fed on basal diet supplemented with 40 mg ferric sulphate/kg diet, 200 mg zinc carbonate /kg diet, 250 mg α-tocohperol acetate/kg/B.W. and 250 mg ascorbic acid/kg/B.W. respectively. Blood samples were collected from each rat and were centrifuged to obtain serum. PTU exposed rats showed hypothyroidism with significant (P<0.05) decline in serum FT3 and FT4 levels together with significant (P<0.05) increase in serum TSH level. The supplementation with Iron, Zinc, Vit.E or Vit.C significantly (P<0.05) increased the level of thyroid hormones (FT4 and FT3) and glutathione peroxidase, moreover, the level of TSH was significantly (P<0.05) decreased, compared with control positive group, might be due to their antioxidant properties. Significant improvement in lipid profile as well as liver and kidney functions were observed. It could be suggested that Vitamin C, Vitamin E, Zinc and Iron could be used as a suitable supplementation therapy for hypothyroidism patients.

show abstract

“…In addition to inducing ROS and other oxides, Hcy also affects the antioxidant capacity of EC [42][43][44], significantly lowering the expression of antioxidants SOD and GSH-Px, resulting in the increase of H 2 O 2 and serious damage to the body's antioxidant capacity. Some studies have shown that [45] the content of Hcy is positively correlated with the content of MDA in response to oxidative stress, and the NO level is significantly lower than that in the normal population, which briefly reflects the endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High‐Methionine Diet

Wang

Hui

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. The aim of this study was to assess the effects of moxibustion on the animal model of oxidative stress and cardiovascular injury induced by high-methionine diet (2% methionine and 3.5% fat on the basis of ordinary maintenance feed) during 12 weeks. Methods. 53 mice were divided into four groups: mice in the Control group (n = 8), mice in the Met group (n = 15), mice in the Met + Moxibustion group (n = 15), and mice in the Met + Smoke group (n = 15). After 12 weeks of intervention, homocysteine (Hcy), S-adenosine homocysteine (SAH), superoxide dismutase (SOD), oxygenized low-density lipoprotein (ox-LDL), endothelial nitric oxide synthase (eNOS), and heme oxygenase-1 (HO-1) were determined in the serum and aortic homogenate. Results. Compared with the Met group, our results indicated that through moxibustion intervention, the content of serum Hcy and its intermediate metabolite SAH can be reduced to a certain extent, and SOD, HO-1, and ox-LDL can be increased. Conclusion. This study showed moxibustion’s ability to enhance the body’s antioxidation and protect vascular endothelial function, thus playing an early role in the prevention and treatment of atherosclerosis.

show abstract

Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders

Cited by 16 publications

References 44 publications

Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism

Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism

Effect of Iron, Zinc, Vitamin E and Vitamin C Supplementation on Thyroid Hormones in Rats with Hypothyroidism

Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High‐Methionine Diet

Contact Info

Product

Resources

About