Lipid profile and high maternal body mass index is associated with preeclampsia: A case-control study of the Cape Coast Metropolis

Ephraim, Rkd; Doe, PA; Amoah, Samuel; Antoh, EO

doi:10.4103/2141-9248.141542

Cited by 29 publications

(29 citation statements)

References 16 publications

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“…Twenty‐seven studies reported on HDL levels,32, 37, 41, 44, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 of which 24 studies could be included in a meta‐analysis 32, 37, 41, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72. HDL level was lower in pre‐eclampsia than in controls (mean difference −6.29 mmol/L; 95%CI −9.74−2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre‐eclampsia vs. controls ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-seven studies reported on HDL levels, 32,37,41,44, of which 24 studies could be included in a metaanalysis. 32,37,41,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] HDL level was lower in pre-eclampsia than in controls (mean difference À6.29 mmol/L; 95%CI À9.74À2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre-eclampsia vs. controls (Figure 4).…”

Section: High-density Lipoproteinmentioning

confidence: 99%

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Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Section: Resultsmentioning

confidence: 99%

Section: High-density Lipoproteinmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…PE is highly associated with hypertension both prior to and following pregnancy 12,13 . Other cardiovascular risk factors including increased levels of total cholesterol, LDL-C, and triglycerides and decreased levels of HDL-C have also been associated with PE 24,41 . The increased long-term risk of cardiovascular disease in women with prior PE includes an increased risk of CAD, ischemic stroke, heart failure, cardiac procedures, and cardiovascular-related hospitalizations [26][27][28][29]42,43 .…”

Section: Identification Of Traits and Their Associated Single Nucleotmentioning

confidence: 99%

Risk of preeclampsia in patients with genetic predisposition to common medical conditions: a case-control study

Gray

Kovacheva

Mirzakhani

et al. 2020

Preprint

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RUNNING TITLE: Preeclampsia genetic predispositionWord count: 3500; Abstract: 246 ABSTRACT Objective: To assess whether women with a genetic predisposition to medical conditions known to increase preeclampsia risk have an increased risk of preeclampsia in pregnancy.Design: Case-control study.Setting and population: Preeclampsia cases (n=498) and controls (n=1864) of European ancestry from 5 US sites genotyped on a cardiovascular gene-centric array.Methods: Significant single nucleotide polymorphisms (SNPs) from 21 traits in 7 disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal, thrombophilia) with published genome-wide association studies (GWAS) were used to create a genetic instrument for each trait. Multivariable logistic regression was used to test the association of each continuous, scaled genetic instrument with preeclampsia. Odds of preeclampsia were compared across quartiles of the genetic instrument and evaluated for significance using a test for trend. Main Outcome Measures: preeclampsia.Results: An increasing burden of risk alleles for elevated diastolic blood pressure (DBP) and increased body mass index (BMI) were associated with an increased risk of preeclampsia (DBP: overall OR 1.11 (1.01-1.21), p=0.025; BMI: OR 1.10 (1.00-1.20), p=0.042), while risk alleles associated with elevated alkaline phosphatase (ALP) were protective (OR 0.89 (0.82-0.97), p=0.008), driven primarily by pleiotropic effects of variants in the FADS gene region. The effect of DBP genetic loci was even greater in early-onset (<34 weeks) preeclampsia cases (OR 1.30 (1.08-1.56), p=0.005). For all other traits, the genetic instrument was not robustly associated with preeclampsia risk. Conclusions:These results suggest that the underlying genetic architecture of preeclampsia is shared with other disorders, specifically hypertension and obesity. ABSTRACT Genetic predisposition to increased diastolic blood pressure and obesity increases the risk of preeclampsia.

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“…VLDL transports TG in peripheral blood therefore hyper triglyceridemia also leads to increased serum levels of VLDL [28]. Insulin resistance causes lipolysis, leading to increased flux of fatty acids to liver promoting synthesis of VLDL [29].…”

Section: Original Research Articlementioning

confidence: 99%

Pre–eclampsia and dyslipidaemia a case control study: an experience of tertiary healthcare centre in central India

Yadav

Jain

Toppo

et al. 2018

Trop J Pathol Microbiol

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Introduction: Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Dyslipidaemia has been shown to play a significant role in the pathogenesis of the disease and often precede linical manifestations. Objective: To compare the serum lipid profile in pre-eclampsia case and normal pregnant women and to assess its role in pre-eclampsia. Material and Method: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of obstetrics and genecology in March 2016 to August 2017. Lipid profile was estimated by the Randoximola is a compact fully automated clinical chemistry analyser. Result: We observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean cholesterol, triglyceride, LDL,VLDL, value is analysed with control group showing significantly increase (p<0.0001) and HDL value significantly decreasedin pre-eclampsia patient in comparison to the normal control group (p<0.0001). Conclusion: Young age, nulliparity, low socioeconomic status specially labour occupation, dyslipidaemic pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of lipid profile may be helpful forearly diagnosis and management of pre-eclampsia in order to prevent fetal and maternal complications especially in nulliparous women.

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Lipid profile and high maternal body mass index is associated with preeclampsia: A case-control study of the Cape Coast Metropolis

Cited by 29 publications

References 16 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Risk of preeclampsia in patients with genetic predisposition to common medical conditions: a case-control study

Pre–eclampsia and dyslipidaemia a case control study: an experience of tertiary healthcare centre in central India

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