LIPID PROFILE AND ALBUMINURIA RELATIONSHIP WITH NUCLEOTIDE POLYMORPHISM –204 А > С [rs 3808607] OF СУР7А1 GENE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ARTERIAL HYPERTENSION

Abstract

The aim of our study is the definition of diabetic nephropathy peculiarities and the relationship between albuminuria and indicators of lipid profile, genotype variants of СУР7А1 for patients with type 2 diabetes mellitus and the third stage of arterial hypertension. Patients are divided into 3 groups. The patients of the I group are defined with normoalbuminuria, microalbuminuria – in the ІІ, macroalbuminuria – in the III. The definition of albumin to creatinin ratio is the most precise, but a more expensive method. The SNP –204 А > С [rs 3808607] of СУР7А1 promotor section is defined. Homozygotes by major allele with AA genotype have the less level of albuminuria, aterogenic lipoproteids, general cholesterol, triglycerides and the biggest level of antiaterogenic lipoproteids in comparison with patients with AC and CC genotype. The genotype CC is the worst in the terms of prognosis because the level of albuminuria, aterogenic lipoproteids, general cholesterol, triglycerides and lipoproteids with low density is increased but the level of lipoproteids with high density is decreased.