Lipid Profile among Patients with Sudden Sensorineural Hearing Loss

Abstract

Associations between hearing and blood lipids have been the focus of scientific inquiry for more than 50 years. The aim of the present study is to evaluate the association between hyperlipidaemia among patients presented with sudden sensorineural hearing loss compared to normal controls. A case control study concerned with 22 patients presented with sudden sensorineural hearing loss who underwent lipid profile evaluation. The lipid profile of these patients was compared with corresponding results of 55 age matched persons (volunteers) with normal hearing. These patients were collected from the Out Patient Department of ENT at Al-Jamhory Teaching Hospital, Mosul/Iraq and private clinic of the author for the period from February 2011 to July 2013. The average age of patients was 44.7 years with a range of 26-65 years. The peak age incidence was in the 5(th) decade of life. The study included 11 male patients (50 %) and 11 females (50 %). Meanwhile, the average age of the control group was 41.7 years with 25 (45.5 %) males and 30 (54.5 %) females. Statistical analysis showed that there was significant difference between the means of lipid profile and blood sugar of the patients and the control group apart from HDL where there was no significant difference. In conclusion, hyperlipidemia seems to be significantly associated with the occurrence of sudden sensorineural hearing loss according to this study.

The atherogenic index (ATH index) as a potential predictive marker of idiopathic sudden sensorineural hearing loss: a case control study

“…At present, there are multiple clinical and animal studies that support a relationship between hyperlipidaemia and hearing loss. Hyperlipidaemia is frequently observed in patients with idiopathic SSNHL [ 20 , 21 ]. In turn, patients with hyperlipidaemia show poor hearing levels at high frequencies [ 16 , 22 ].…”

A novel pathogenic variant in OSBPL2 linked to hereditary late-onset deafness in a Mongolian family

“…Some studies have tried to explain the role of membrane cholesterol in the physiology of hair cells [ 15 ]. A recent study tried to connect the relationship between hearing loss and high cholesterol, and found that hearing level seems to be affected by hyperlipidemia [ 16 ].…”

“…OSBPL2 is highly expressed in the inner and outer hair cells of the mouse cochlea [ 13 , 14 ] and cholesterol level in hair cells seems to affect hearing [ 16 ]. It is plausible that OSBPL2 is the major OSBP gene expressed in hair cells, which could be very sensitive to the dosage of OSBPL2 .…”

Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

“…The details of the estimation of the propensity score matching were as follows: Age, gender, side, time elapse, hypertension, diabetes, heart disease, vertigo, contralateral deafness, initial hearing loss, audiogram type, hyperlipidemia type and hospital stay were selected as covariates based on the results of the previous studies Lipid‐lowering therapy Group and CG were treated as grouping variables.…”