Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

Dave, Vivek; Tak, Kajal; Sohgaura, Amit; Gupta, Ashish; Sadhu, Veera; Reddy, Kakarla Raghava

doi:10.1016/j.mimet.2019.03.017

Cited by 162 publications

(93 citation statements)

References 75 publications

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“…As has been well documented, efficient drug delivery carriers should not only be biocompatible to ensure safety aspects of nano delivery vehicles, but also be suitable to stabilize and protect biomolecules against harsh physical and biochemical attacks in biological environments, subsequently to deliver genes/drugs into the target-specific tissue and release them in the controlled manner. To date, as nonviral vectors, micelles, liposomes, and polymer-based nano delivery carriers have been developed as up-to-date drug delivery systems (DDSs) [45][46][47][48][49][50][51][52][53][54], but they are inherently [3,12,17]. Images in parts 'hydrotalcite-Talcid ® ' courtesy of Bayer, Germany and Gattefosse, France.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

et al. 2020

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Biocompatible hydrotalcite nanohybrids, i.e., layered double hydroxide (LDH) based nanohybrids have attracted significant attention for biomedical functions. Benefiting from good biocompatibility, tailored drug incorporation, high drug loading capacity, targeted cellular delivery and natural pH-responsive biodegradability, hydrotalcite nanohybrids have shown great potential in drug/gene delivery, cancer therapy and bio-imaging. This review aims to summarize recent progress of hydrotalcite nanohybrids, including the history of the hydrotalcite-like compounds for application in the medical field, synthesis, functionalization, physicochemical properties, cytotoxicity, cellular uptake mechanism, as well as their related applications in biomedicine. The potential and challenges will also be discussed for further development of LDHs both as drug delivery carriers and diagnostic agents.

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Section: Introductionmentioning

confidence: 99%

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

et al. 2020

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“…In the method, the different layers comprise of structurally, different components were separately fabricated and then co incubated to make a complete particle by using the various approaches including the adsorption, self-assembling and encapsulation. The core and shell morphology might be obtained and the various hybrid nanoparticles were obtained by using the sonication [19], solvent emulsification, solvent evaporation [13], nanoprecipitation [20], extrusion, high speed homogenizers and other techniques. However, the selection of the method is based on the physicochemical properties of the loaded drug, size of the core particle and the desired properties that you want to introduce in the NP formulation [18].…”

Section: Two-step Conventional Methodsmentioning

confidence: 99%

Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery

Nawaz¹,

Haseeb²,

Madni³

et al. 2020

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

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Applications of nanotechnology and material sciences emerge in the development of various novel drug delivery systems that have been proven as promising clinically. Among these, liposomes, noisome, polymeric carriers and lipid-based delivery system were extensively explored and enter into clinical trials and clinical applications. However, each system has its own pros and cons in term of different physicochemical, pharmacokinetics and therapeutics aspects. Lipid-polymer hybrid carriers merge the potential benefit of these structural components and can be prepared by different approaches to improve the therapeutic outcomes. In this chapter, we provide the useful insight about the lipid-polymer hybrid nanoparticles (LPHNPs) that can be prepared by using the different structural components including the synthetic and natural polymers and lipids. Among these, we also explain the various methods to prepare the LPHNPs with various desired characteristics. Finally, the various therapeutic and clinical applications have been presented briefly.

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“…However, their low encapsulation efficiency hinders their potential to be widely pursued in the biomedical field [61]. Since both lipid-based and polymer-based nanoparticles have their own limitations, lipid-polymer hybrid nanoparticles have recently been developed to provide wider opportunities for the biomedical applications [62]. New polymer liposomes such as electrostatically crosslinked polymer-liposomes have also been developed [63].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

Cited by 162 publications

References 75 publications

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

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