Lipid peroxides and atherosclerosis

Abstract

Plasma lipid peroxide concentrations were measured in 100 patients with occlusive arterial disease proved angiographically (50 patients with ischaemic heart disease, 50 with peripheral arterial disease) and compared with values in 75 control patients with no clinical evidence of atherosclerosis. Lipid peroxide concentrations were significantly higher in patients both with ischaemic heart disease (median 4-37 iimol/l (interquartile range 3-85-5-75 [tmol/l); p<0-001) and with peripheral arterial disease (median 4-37 [smoltl (3-88-5-21 [mol/l); p<0001) than in controls (median 3-65 [tmol/l (interquartile range 3-29-3-89 [mol/l)).Overall there was a significant but weak correlation between plasma lipid peroxide and plasma triglyceride concentrations (r,=0-25; p<0-001) but not between plasma lipid peroxide and plasma total cholesterol concentrations. Furthermore, hypertension, obesity, diabetes, smoking, positive family history, and intake of fi blockers and thiazide diuretics were not associated with significant differences in lipid peroxide values.This study provides clinical support to experimental data indicating that peroxidised lipids may be important in atherogenesis and its complications and also suggests that peroxidised lipids may provide an index of the severity of atherosclerosis.Thrombosis Research

Peroxidation Potential and Antioxidant Activity of Serum in Patients with Diabetes Mellitus and Myocard Infarction

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Effect of Eugenia Jambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats

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Antioxidant vitamins and prevention of cardiovascular disease: Epidemiological and clinical trial data

“…At least six case-control studies on vitamin E and CVD risk were published (79,81,82,(96)(97)(98)(99). They were small in size (n = 1,846) and their results did not agree (OR, 0.88; 95% CI, 0.70 to 1.09).…”