Lipid Peroxidation Originating α,β‐unsaturated Aldehydes and Their Metabolites as Biomarkers

Guéraud, Françoise

doi:10.1002/9780813814438.ch8

Cited by 4 publications

(5 citation statements)

References 116 publications

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“…Malonyldialdehyde (MDA) levels in the liver of the controls and β-MSH treated groups were analyzed considering the fact that hepatic cytochrome P450 enzymes down-regulation and oxidative stress are found in TNBS-induced colitis [ 26 ]. MDA is an aldehydic product of lipid peroxidation that has been the most used as a marker of the oxidative stress [ 27 ]. In the Wistar rats ß-MSH significantly reduced liver levels of MDA from 9.76 μM (interquartile range 8.66–12.31) in the control group to the level of 7.84 μM (interquartile range 6.10–8.65) in the group treated with 0.250 mg/kg ß-MSH ( Figure 5 , Mann-Whitney test, p = 0.007).…”

Section: Resultsmentioning

confidence: 99%

“…Malondialdehyde (MDA) levels in plasma and liver were determined by MDA-TBARS assay, a colorimetric determination by the thiobarbituric acid reactive substances (TBARS) [ 27 ]. Chemicals and reagents were as follows: BHT [2,6 di - ter - butyl -4-methylphenol, ≥99.0% (GC); (Sigma-Aldrich Inc., St. Louis, MO, USA)], TCA (trichloroacetic acid, ≥98%; Sigma-Aldrich Inc.), TBA (thiobarbituric acid, ≥98%; Sigma-Aldrich Inc.), ethanol 98% (Merck, Darmstadt, Germany), HCl (37%; puriss.…”

Section: Methodsmentioning

confidence: 99%

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Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract

et al. 2012

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Recently discovered anti-inflammatory and immunomodulatory properties of melanocortin peptides led to the conclusion that they might serve as new anti-inflammatory therapeutics. The purpose of this work was to examine the effectiveness of β-melanocortin (β-MSH) in two experimental models: ethanol-induced gastric lesions and TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced colitis in male Wistar rats. Three progressive doses of β-MSH were used: 0.125, 0.250 and 0.500 mg/kg. Our results suggest that β-MSH acts as a protective substance in the gastric lesions model, which can be seen as a statistically significant reduction of hemorrhagic lesions at all three doses, compared to the control group. The most efficient dose was 0.250 mg/kg. Statistically significant reduction in mucosal surface affected by necrosis and the reduction of overall degree of inflammation in the colitis model indicates an anti-inflammatory effect of β-MSH at a dose of 0.250 mg/kg. The results justify further research on β-MSH peptide and its derivates in the inflammatory gastrointestinal diseases, and point out the possibility of using β-MSH in studies of digestive system pharmacology.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract

et al. 2012

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“…It is a tripeptide involved not only in the GPx mediated removal of lipid peroxides and H 2 O 2 , but also in the reduction of oxidized thiol groups of proteins [ 47 ]. It is also used by GST to conjugate electrophilic compounds in order to render less chemically active compounds and to ensure their clearance from the organism [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…MDA is an iconic biomarker of lipid peroxidation that is produced after ROS mediated oxidation of the polyunsaturated fatty acids (PUFA). The long chains of PUFA are prone to sequential oxidations that could lead to cleavage and render small end products, such as MDA [ 37 , 48 ]. The content of MDA suggests that both starvation/refeeding regimes induced oxidative stress that led to lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Antioxidant Defense Mechanisms in Response to Starvation and Refeeding in the Intestine of Stellate Sturgeon (Acipenser stellatus) Juveniles from Aquaculture

Gune

Georgescu

Dudu

et al. 2021

Animals

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Acipenser stellatus is a critically endangered species due to the anthropic influence. It has been intensively captured for decades because of its high economic value, its roe being used in the caviar industry. Therefore, Acipenser stellatus is intensively raised in fish farms for both conservation and economical purposes. Aquaculture aims to optimize the feeding regime of juveniles in order to improve its profitability. The purpose of this study was to investigate if Acipenser stellatus can adapt to a starvation/refeeding regime by assessing the effects of this regime on oxidative stress biomarkers and antioxidant defense mechanisms in juveniles raised under aquaculture conditions. The juveniles were subjected to two regimes: a 7-day starvation period followed by 21 days of refeeding, respectively a 14-day starvation period followed by 21 days of refeeding. The results showed that both starvation/refeeding regimes induced an enhancement of antioxidant enzymes activities in the intestine of the juveniles. The oxidative damage was counteracted at the protein level. However, lipid peroxidation was significantly induced in the intestine of the juveniles subjected to 14/21-day starvation/refeeding regime. The 7/21-day starvation/refeeding regime proved to be more suitable for Acipenser stellatus and therefore, it could be useful to optimize the feeding practice in aquaculture production.

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“…It is an aldehyde produced after ROS mediated oxidation of the polyunsaturated fatty acids (PUFA). The long chains of PUFA are prone to sequential oxidations that could lead to cleavage and render small end products, such as MDA (Guérod, 2010;Bansal & Kaushal, 2014) (S1). Starvation induced a decrease in the MDA level in comparison to the constant feeding regime, while refeeding increased the MDA level so it reached the control level (Fig.…”

Section: Oxidative Changes In the Biomoleculesmentioning

confidence: 99%

Effects of starvation and refeeding on growth performance and stress defense mechanisms of stellate sturgeon Acipenser stellatus juveniles from aquaculture

et al. 2019

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Acipenser stellatus represents a species of great economical interest due to its roe used for caviar production. Therefore, it has been intensively captured for decades and nowadays, this species is on the verge of extinction. As a consequence, Acipenser stellatus is intensively raised in fish farms. Aquaculture is focused on optimizing the feeding regime of juveniles. The aim of this study was to investigate if Acipenser stellatus can adapt to a starvation/refeeding regime by assessing the effects of this regime on growth performance, oxidative stress biomarkers and heat shock protein (hsp) gene expression in juveniles raised under aquaculture conditions. The juveniles were subjected to two starvation/refeeding regimes: a 7-day starvation period followed by 21 days of refeeding, and a14-day starvation period followed by 21 days of refeeding. The results had shown that the juveniles subjected to 7/21-day starvation/refeeding regime presented a complete compensatory growth, they were able to counteract the oxidative stress by enhancing activities of the antioxidant enzymes and they presented no significant changes in hsp gene expression. In contrast, 14/21-day starvation/refeeding regime negatively influenced growth performance, it induced a high level of oxidative stress that was impossible to counteract and it determined major changes in the hsp gene expression level in the liver of Acipenser stellatus. Thus, Acipenser stellatus seems to be able to adapt only to the 7/21-day starvation/refeeding regime that does not threaten the growth performance and the welfare of juveniles. Therefore, it could be useful to optimize the feeding practice in aquaculture production.

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Lipid Peroxidation Originating α,β‐unsaturated Aldehydes and Their Metabolites as Biomarkers

Cited by 4 publications

References 116 publications

Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract

Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract

Oxidative Stress and Antioxidant Defense Mechanisms in Response to Starvation and Refeeding in the Intestine of Stellate Sturgeon (Acipenser stellatus) Juveniles from Aquaculture

Effects of starvation and refeeding on growth performance and stress defense mechanisms of stellate sturgeon Acipenser stellatus juveniles from aquaculture

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