Lipid Peroxidation of Liposome Induced by Glucosone.

Abstract

SummaryLipid peroxidation of liposome made of egg lecithin was induced by glucosone (D-arabino-hexos-2-ulose), a secondary product of Maillard reaction or glycation of protein. Lipid peroxidation was assessed with measurement of TBARS (thiobarbituric acid reacting substances), POV (peroxide value), and HPLC measurement of MDA (malondialde hyde).EDTA and DTPA (diethylenetriamine-pentaacetic acid) in hibited the lipid peroxidation assessed by each method described above, indicating involvement of metal ions. The observed reduction of Fe3+ to Fe2+ by glucosone might be a critical step of the lipid peroxidation. Our findings suggest a possible role of lipid peroxidation of low-density lipo proteins (LDL) induced by glucosone in atherosis caused by diabetes mellitus.

Deutscher Lebensmittelchemikertag 2014 in Gießen

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