Lipid peroxidation: Mechanisms, inhibition, and biological effects

Niki, Etsuo; Yoshida, Yasukazu; Saito, Yoshiro; Noguchi, Noriko

doi:10.1016/j.bbrc.2005.08.072

Cited by 727 publications

(490 citation statements)

References 63 publications

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“…In fact, the non-enzymatic peroxidation is a known process (Niki et al 2005), mainly involving unsaturated fats (Spiteller 2010), being further enhanced in our experiments, due to the culture medium incubation in the presence of atmospheric oxygen (21 %). The concentration of the five studied HETE did not significantly change in the three culture media used (basal, adipogenic and osteogenic) after incubation in the presence of AA without cells.…”

Section: Discussionmentioning

confidence: 74%

“…The enzyme phospholipase A2 (PLA2) initiates the COX or LOX pathway by catalyzing the hydrolysis of AA from the membrane phospholipids. LOX acts on liberated free AA to generate hydroperoxyeicosatetraenoic acids, which are unstable intermediates, being further either hydrolyzed into hydroxyeicosatetraenoic acids (HETE) via lipoxygenase catalysis or by non-enzymatic oxidative reactions (Niki et al 2005), or enzymatically converted into leukotrienes such as 5(6)-epoxy(oxido)eicosatetraenoic acid (leukotriene A4; LTA4) and lipoxins, which may be involved in important physiological events such as inflammation (Wahli and Michalik 2012). On the other hand, the HETE are PPARc agonists and may influence cellular differentiation (Ban et al 2011;Yu et al 1995).…”

Section: Introductionmentioning

confidence: 99%

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Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

et al. 2013

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Metabolites derived from the polyunsaturated fatty acids (PUFA) may modulate the mesenchymal stromal cell (MSC) differentiation. Such cells can differentiate into different cellular types, including adipocytes and osteoblasts. Aging favors the bone marrow MSC differentiation toward the former, causing a loss of bone density associated with pathologies like osteoporosis. The omega-6 arachidonic acid (AA) favors MSC adipogenesis to a greater extent than omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this work, we study the joint action of both PUFA. Thus, not induced and induced to adipocyte or osteoblast MSC were treated with 20 lM of each PUFA (either AA, AA ? DHA or AA ? EPA). The expression of osteogenic and adipogenic molecular markers, the alox15b lipoxygenase gene expression and the 5-, 8-, 11-, 12-and 15-hydroxyeicosatetraenoic acids (HETE) derived from the AA metabolism in the culture media were determined. The results show that the adipogenesis induction of AA is not suppressed by the joint presence of EPA and DHA. In fact, both increased the adipogenic effect of AA on MSC differentiated into osteoblasts. The different HETE concentrations increased in cultures supplemented with AA, albeit such concentrations were lower in the cultures induced to differentiate, mainly at day 21 after the induction. Furthermore, the reduction in the HETE concentration was correlated with a higher expression of the alox15b gene. These results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction.

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

et al. 2013

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“…In most investigations, the privileged targets are natural or synthetic substances having improved ability to (i) interrupt free radical-mediated chains of cell lipid peroxidation by scavenging free radicals or inactivating metal ions catalysts such as Fe 2+ or (ii) retard or prevent new free radical chains to form, e.g., by decreasing local oxygen concentration [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress

Cassien

Petrocchi

Thétiot-Laurent

et al. 2016

European Journal of Medicinal Chemistry

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A series of new hybrid 2-(diethoxyphosphoryl)-N-(benzylidene)propan-2-amine oxide derivatives with different aromatic substitution (PPNs) were synthesized. These molecules were evaluated for their EPR spin trapping potential and NO donation properties in vitro, their cytotoxicity and on precontracted rat aortic rings. A subfamily of the new PPNs featured an antioxidant moiety occurring in natural phenolic acids. From the experimental screening of these hydroxyphenyl-and methoxyphenyl-substituted PPNs, biocompatible nitrones 4d, 4g−i deriving from caffeic, gallic, ferulic and sinapic acids, which combined improved EPR probing of ROS formation, vasorelaxant action and antioxidant potency, might be potential drug candidate alternatives to PBN and its analogues.

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“…Oxidation in biological tissues should be avoided because some negative biological effects have been attributed to lipid oxidation products (Guardiola et al, 2002;Niki et al, 2005;Spiteller, 2006). In meat and food products, oxidation might lead to a reduction of the sensory and nutritional quality (Gray et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…In meat however, LO increased TBA values . Therefore, although the increase in PUFA in tissues may be interesting from a nutritional point of view, and in the prevention of some chronic diseases (Kinsella et al, 1990;Simopoulos, 1997;Siddiqui et al, 2008), it might cause a reduction in aT content and an increase in tissue oxidability that should be avoided, due to the negative biological effects that have been described for various oxidation compounds (Guardiola et al, 2002;Niki et al, 2005;Spiteller, 2006).…”

mentioning

confidence: 99%

Dietary n-6- or n-3-rich vegetable fats and α-tocopheryl acetate: effects on fatty acid composition and stability of rabbit plasma, liver and meat

Tres

Bou

Codony

et al. 2009

Animal

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We supplemented diets with a-tocopheryl acetate (100 mg/kg) and replaced beef tallow (BT) in feeds with increasing doses of n-6-or n-3-rich vegetable fat sources (linseed and sunflower oil), and studied the effects on the fatty acid (FA) composition, the a-tocopherol (aT) content and the oxidative stability of rabbit plasma and liver. These effects were compared with those observed in a previous study in rabbit meat. As in meat, the content of saturated, monounsaturated and trans FA in plasma and liver mainly reflected feed FA profile, except stearic acid in liver, which increased as feeds contained higher doses of vegetable fat, which could be related to an inhibition of the activity of the stearoyl-CoA-desaturase. As linseed oil increased in feeds, the n-6/n-3 FA ratio was decreased in plasma and liver as a result of the incorporation of FA from diets and also, due to the different performance and selectivity of desaturase enzymes. However, an increase in the dose of vegetable fat in feeds led to a significant reduction in the aT content of plasma and liver, which was greater when the fat source was linseed oil. Increasing the dose of vegetable fat in feeds also led to an increase in the susceptibility to oxidation (lipid hydroperoxide (LHP) value) of rabbit plasma, liver and meat and on the thiobarbituric acid (TBA) values of meat. Although the dietary supplementation with a-tocopheryl acetate increased the aT content in plasma and liver, it did not modify significantly their TBA or LHP values. In meat however, both TBA and LHP values were reduced by the dietary supplementation with a-tocopheryl acetate. The plasma aT content reflected the aT content in tissues, and correlated negatively with tissue oxidability. From the studied diets, those containing 1.5% linseed oil plus 1.5% BT and 100 mg of a-tocopheryl acetate/kg most improved the FA composition and the oxidative stability of rabbit tissues.

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Lipid peroxidation: Mechanisms, inhibition, and biological effects

Cited by 727 publications

References 63 publications

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress

Dietary n-6- or n-3-rich vegetable fats and α-tocopheryl acetate: effects on fatty acid composition and stability of rabbit plasma, liver and meat

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