Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis

Akalın, Ferda Alev; Baltacıoğlu, Esra; Alver, Ahmet; Karabulut, Erdem

doi:10.1111/j.1600-051x.2007.01091.x

Cited by 261 publications

(311 citation statements)

References 55 publications

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“…Thus our study establishes that there exists a positive association between periodontitis and blood ROS levels and reiterates that ROS produced in the periodontal lesion may spread to the blood stream. These results are in agreement with the observations made by Tamaki et al 14 , Akalin et al 16 and Baltaciog et al in their respective studies.…”

Section: Discussion:-supporting

confidence: 94%

EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE AND PLASMA LEVELS OF REACTIVE OXYGEN METABOLITES (ROMs) IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

Mehta.¹

2017

IJAR

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Background: Recent evidences have indicated that the physiological amount of boron in the diet is known to influence the numerous metabolic parameters in addition to its vital role in osteogenesis and the maintenance of bone. The purpose of the present study was to evaluate the morphometric and histopathologic effects of systemic boric acid in a rat periodontitis model to correlate it with the biochemical markers of bone metabolism i.e. serum calcium and alkaline phosphatase and reactive oxygen metabolites (ROMs) levels in ligature induced periodontitis model in rat. Methods: Thirty Wistar rats were divided into three groups of ten animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the maxillary second molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and histologically .

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Section: Discussion:-supporting

confidence: 94%

EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE AND PLASMA LEVELS OF REACTIVE OXYGEN METABOLITES (ROMs) IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

Mehta.¹

2017

IJAR

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“…It represents the oral condition and also has some elements of gingival crevicular fluid (GCF) and tissue metabolites that may be helpful in the tissue degradation. In addition, stimulated salivary flow has been proved to increase saliva volume and disrupt the concentration [31][32][33]. There are evidences that saliva has considerable antioxidant capacity, and oxidative stress may happen as a consequence of LPO, and impaired capacity of saliva antioxidant power.…”

Section: Discussionmentioning

confidence: 99%

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Latha

Uppoor

Nayak

et al. 2018

Asian J Pharm Clin Res

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Objective: Reactive oxygen species have been identified as potential factors causing periodontal tissue destruction. Elevated levels of these in patients with chronic periodontitis and diabetes may aggravate the oxidative stress burden thereby accelerating the tissue damage associated with diabetes. The present study aimed to assess the effect of diabetes and periodontal disease on the oxidative stress markers and the effect of non-surgical therapy on these markers.Methods: A total of 50 participants were divided into four groups based on the selection criteria. In addition to clinical parameters and biochemical parameters (salivary nitric oxide [NO] and malondialdehyde [MDA] levels) were assessed using spectrophotometric method at baseline and 3 months after non-surgical periodontal therapy.Result: There was a statistically significant difference in the clinical parameters as well as NO and MDA levels in patients with type 2 diabetes and chronic periodontitis than other three groups at baseline and at 3 months after non-surgical periodontal therapy. Conclusion:Diabetes mellitus and periodontitis have a compounding effect on the oxidative stress. Periodontal therapy is essential for diabetic patients as it can lower the levels of oxidative damage.

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“…Several studies have addressed the role of oxidative stress in the pathology of oral and dental diseases, especially periodontitis [1,2,13,54] and the hypothesis that good oral hygiene may decrease oxidative stress in saliva was proposed [53]. In our study, saliva samples collected before and 10 minutes after tooth-brushing were monitored.…”

Section: Effect Of Tooth-brushingmentioning

confidence: 99%

“…In association with oral and dental diseases (especially periodontitis), changed oxidative stress markers in saliva were reported [2,46,51]. Being a noninvasive biofluid, saliva allows easy, noninvasive and safe sam-ple collection.…”

Section: Introductionmentioning

confidence: 99%

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

2013

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Abstract.BACKGROUND: Salivary markers of oxidative stress and antioxidant status represent promising tool for the research of oral diseases. One of the criteria is the validation of these biomarkers from the perspective of the confounding and modifying factors. AIM: To examine the effect of circadian rhythm, tooth-brushing and ascorbic acid treatment on selected salivary markers of oxidative and carbonyl stress, and antioxidant status. SUBJECTS AND METHODS: Whole unstimulated saliva samples were collected from 19 healthy participants three times during a day, before and after tooth-brushing, and before and after the administration of vitamin C (250 mg). Advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs), ferric reducing antioxidant power (FRAP) and total antioxidant capacity (TAC) were measured. RESULTS: Salivary AGEs levels varied significantly during the day (p < 0.05) with the highest concentrations in the morning. FRAP levels varied during the day (p < 0.01) with the highest concentrations in the afternoon. Tooth-brushing decreased AGEs (p < 0.05) and TBARS levels (p < 0.01) and increased FRAP levels (p < 0.05). Single intake of vitamin C significantly decreased AGEs (p < 0.001) and increased both FRAP (p < 0.01) and TAC (p < 0.01) concentrations. CONCLUSION: Significant daily variations were observed in salivary AGEs and FRAP levels. Tooth-brushing and treatment with vitamin C decreased carbonyl stress and increased the antioxidant status. These results are important from the perspective of using saliva for the research of oral diseases.

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Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis

Cited by 261 publications

References 55 publications

EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE AND PLASMA LEVELS OF REACTIVE OXYGEN METABOLITES (ROMs) IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE AND PLASMA LEVELS OF REACTIVE OXYGEN METABOLITES (ROMs) IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Salivary Markers of Oxidative Stress and Antioxidant Status: Influence of External Factors

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