Lipid peroxidation in the fungus Curvularia lunata exposed to nickel

Paraszkiewicz, Katarzyna; Bernat, Przemysław; Naliwajski, Marcin; Długoński, Jerzy

doi:10.1007/s00203-009-0542-3

Cited by 27 publications

(7 citation statements)

References 31 publications

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“…163 Nickel-toxified filamentous fungus Curvularia lunata had an increase in membrane lipid saturation and an enhanced level of thiobarbituric acid reactive substances (TBARS) 164 . TBARS are lipid degradation products used as an indirect measure of lipid peroxidation.…”

Section: 0 Nickel Toxicitymentioning

confidence: 99%

Mechanisms of nickel toxicity in microorganisms

2011

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Summary Nickel has long been known to be an important human toxicant, including having the ability to form carcinomas, but until recently nickel was believed to be an issue only to microorganisms living in nickel-rich serpentine soils or areas contaminated by industrial pollution. This assumption was overturned by the discovery of a nickel defense system (RcnR/RcnA) found in microorganisms that live in a wide range of environmental niches, suggesting that nickel homeostasis is a general biological concern. To date, the mechanisms of nickel toxicity in microorganisms and higher eukaryotes are poorly understood. In this review, we summarize nickel homeostasis processes used by microorganisms and highlight in vivo and in vitro effects of exposure to elevated concentrations of nickel. On the basis of this evidence we propose four mechanisms of nickel toxicity: 1) nickel replaces the essential metal of metalloproteins, 2) nickel binds to catalytic residues of non-metalloenzymes; 3) nickel binds outside the catalytic site of an enzyme to inhibit allosterically, and 4) nickel indirectly causes oxidative stress.

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Section: 0 Nickel Toxicitymentioning

confidence: 99%

Mechanisms of nickel toxicity in microorganisms

2011

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“…also had rough texture due to protrusions on the hyphae on exposure to 50 mM of arsenate solution. Such modifications on the surface of fungi indicate the production of intracellular compounds due to heavy metals stress and result in increase in pressure within the mycelia leading to the outward growth of the cell wall structures [47]. Courbot et al [48] have also observed that the impact of metal stresses had led to production of thiol compounds, especially GSH and MT due to intracellular detoxification of cadmium in the fungi, Paxillus involutus.…”

Section: Resultsmentioning

confidence: 99%

The Uptake Mechanism of Cd(II), Cr(VI), Cu(II), Pb(II), and Zn(II) by Mycelia and Fruiting Bodies ofGalerina vittiformis

Damodaran

Balakrishnan

Shetty

2013

BioMed Research International

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Optimum concentrations of heavy metals like copper, cadmium, lead, chromium, and zinc in soil are essential in carrying out various cellular activities in minimum concentrations and hence help in sustaining all life forms, although higher concentration of these metals is lethal to most of the life forms. Galerina vittiformis, a macrofungus, was found to accumulate these heavy metals into its fleshy fruiting body in the order Pb(II) > Cd(II) > Cu(II) > Zn(II) > Cr(VI) from 50 mg/kg soil. It possesses various ranges of potential cellular mechanisms that may be involved in detoxification of heavy metals and thus increases its tolerance to heavy metal stress, mainly by producing organic acids and phytochelatins (PCs). These components help in repairing stress damaged proteins and compartmentalisation of metals to vacuoles. The stress tolerance mechanism can be deduced by various analytical tools like SEM-EDX, FTIR, and LC-MS. Production of two kinds of phytochelatins was observed in the organism in response to metal stress.

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“…growing on maize. Paraszkiewicz et al [26] showed that nickel induces enhanced lipid peroxidation in the mycelium of C. lunata. Also, Zhang et al [27] showed that C. lunata enhances the level of lipid peroxidation products in mangrove plant seedlings.…”

Section: Toxicity Activitymentioning

confidence: 99%

Potential of Endophytic Fungi to Reduce Calotropis Procera Leaves Toxicity in Jeddah, Saudi Arabia

Najjar¹,

Alharbi²,

Bohkari³

et al. 2021

Pharmacophore

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Calotropis procera (Ushar) leaves are frequently used in traditional medicine to treat several diseases. However, the plant contains toxic compounds rendering it unsafe material. Hence, the objective of this study was to treat C. procera dried leaves powder by bioprospecting for fungal endophytes to be a safe applications. Three selected fungal isolates including Cladosporium sphaerospermum, Cochliobolus lunata and Cochliobolus sp.were used for the reduction of C. procera dried leaves powder toxicity. Sporulation of each of these fungi was increased in the presence of 2 g more than 1 g of dried leaves powder in PDB media at 25°C within 4 weeks of incubation. Also, C. sphaerospermum, Cochliobolus sp., and C. lunata were tested for their ability to reduce the toxicity of C. procera dried leaves powder by using thin-layer chromatography (TLC). Only C. sphaerospermum showed the ability to reduce the Calactin toxin presented in powdered leaves Furthermore, the toxicity test of dried leaves powder treated by C. sphaerospermum showed significant (100%) survival of the adult earthworm Lumbricusrubellus compared to the negative control, which induced 100% mortality of worms. These results were also comparable with C. sphaerospermum powdered mycelium, which showed no signs of toxicity. It can be concluded that fungal endophytes such as C. sphaerospermum are promising candidates for eliminating leaves toxicity.

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Lipid peroxidation in the fungus Curvularia lunata exposed to nickel

Cited by 27 publications

References 31 publications

Mechanisms of nickel toxicity in microorganisms

Mechanisms of nickel toxicity in microorganisms

The Uptake Mechanism of Cd(II), Cr(VI), Cu(II), Pb(II), and Zn(II) by Mycelia and Fruiting Bodies ofGalerina vittiformis

Potential of Endophytic Fungi to Reduce Calotropis Procera Leaves Toxicity in Jeddah, Saudi Arabia

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