Lipid peroxidation in liver of vitamin B-6 deficient rats

Selvam, Ramasamy

doi:10.1016/0955-2863(91)90082-g

Cited by 24 publications

(22 citation statements)

References 56 publications

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“…Although vitamin B6 is one of the constituents of many multivitamin formulations and is shown to have antioxidant properties (Selvam and Ravichandran, 1991;Kannan and Jain, 2004;Bilski et al, 2000), its potential against experimentally induced oxidative stress has not been examined. In the present study, the efficacy of vitamin B6 was investigated against Cr-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…While vitamin B6 deficiency increased oxidative stress (Selvam and Ravichandran, 1991), vitamin B6 supplementation reduced oxidative stress related complications in diabetes and neurodegenerative diseases to varying degrees (Fairfield and Fletcher, 2002;Cohen et al, 1984) and increased GPX and selenium (Se) in erythrocytes and muscles (Yin et al, 1991). Vitamin B6 has also been shown to participate in the maintenance of GSH levels by acting as a cofactor in the synthesis of cysteine (Grimble, 1997).…”

Section: Introductionmentioning

confidence: 98%

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Protective effect of vitamin B6 in chromium-induced oxidative stress in liver

Anand

2005

J. Appl. Toxicol.

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The aim of this study was to examine the efficacy of vitamin B6 against chromium (Cr)-induced oxidative stress. Adult male albino Wistar rats (100-120 g) were used in this study. Potassium dichromate, a Cr VI compound, was administered at a dose of 127 mg kg(-1) p.o. Vitamin B6 (pyridoxine hydrochloride) was administered at a dose of 100 mg kg(-1) p.o. either alone or 12 h prior to Cr or simultaneously with Cr. Chromium treatment induced oxidative stress in the liver as measured by increased lipid peroxidation (LPO) and decreased vitamin C, vitamin E, glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione reductase (GR). Both pre- and simultaneous treatments countered Cr-induced oxidative stress; pre-treatment was more effective than concurrent administration. The results demonstrate the antioxidant potential of vitamin B6.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Protective effect of vitamin B6 in chromium-induced oxidative stress in liver

Anand

2005

J. Appl. Toxicol.

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“…G6Pase is known to be inhibited by LPO (22). Decreased levels of total thiols as well as protein thiol have been reported in the urolithic rat liver and kidney when fed with vitamin B6 deficient diet or sodium glycolate-supplemented diet (23,24). Feeding SH-generating substance like methionine (25) or free radical scavengers like Vit .…”

Section: Discussionmentioning

confidence: 99%

Effect of Cyclosporin a on Tissue Lipid Peroxidation and Membrane Bound Phosphatases in Hyperoxaluric Rat and the Protection by Vitamin E Pretreatment

Marimuthu

Selvam

1997

JJMSB

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SUMMARY: The effect of cyclosporin A, a highly effective immunosuppressant, was investigated on hyperoxaluric rats with and without vitamin E pretreatment. Hyperoxaluria was induced by oral feeding of 3% ammonium oxalate in water for 3 days. Cyclosprin A (50 mg/kg body wt.) was administered for 3 days . Pretreatment with vitamin E (50 mg/100 g body wt., once a week for 3 weeks) was carried out before the administration of cyclosproin A and ammonium oxalate . Nonenzymatic ascorbate-induced lipid peroxidation was increased to 1.55-fold in either cyclosporin A-administered or hyperoxaluric rat kidney and liver when compared to control. The lipid peroxidation was further elevated to 1 .9-fold when both cyclosporin A and ammonium oxalate were coadministered . The activities of renal and hepatic ATPase, glucose-6-phosphatase as well as the concentrations of thiols were decreased significantly (p<0.001) when cyclosporin A was administered under hyperoxaluric condition. On pretreatment with vitamin E the cyclosporin A-induced biochemical changes observed in the presence of hyperoxaluria were abolished.

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“…Brattström et al (1990) have previously observed that vitamin B 6 treatment reduced the plasma total cholesterol and LDL-cholesterol in atherosclerotic patients with subnormal plasma B 6 . It has been reported that B 6 deficiency leads to fatty liver, accumulation of total lipids, mainly of TGs and cholesterol ester in the liver (Selvam and Ravichandran 1991) and impair the metabolism of polyunsaturated fatty acid (Tsuge et al 2000). Improvement in the lipidemic profile in the dialysis patients were reported after supplementation with vitamin B 6 (Ziakka et al 2001).…”

Section: Discussionmentioning

confidence: 98%

The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

EL-Toweissy

Mohamed

Abdel-Wahab

2013

Braz. arch. biol. technol.

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This study was undertaken to determine the modulating effects of intramuscular administration of melatonin (MT)(1mg / kg) and/or Tri-B (B 1 , B 6 and B 12 ) (20mg/kg) on body weight and some biochemical changes in rats induced by Epinephrine (Epi) injection. The data showed that MT and/or Tri-B treatment effectively improved the changes in malondialdehyde, lipid profile, blood sugar level and insulin. MT and/or Tri-B administration following Epi improved partially the decrease in body weight and liver glycogen levels. Tri B injection following Epi partialy improved all the tested parameters except malondialdehyde and blood sugar level that completely improved in stressed rats. It was evident that a combination of MT and vitamin B complex had protective actions and further it

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Lipid peroxidation in liver of vitamin B-6 deficient rats

Cited by 24 publications

References 56 publications

Protective effect of vitamin B6 in chromium-induced oxidative stress in liver

Protective effect of vitamin B6 in chromium-induced oxidative stress in liver

Effect of Cyclosporin a on Tissue Lipid Peroxidation and Membrane Bound Phosphatases in Hyperoxaluric Rat and the Protection by Vitamin E Pretreatment

The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

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