Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News

Pizzimenti, Stefania; Toaldo, Cristina; Pettazzoni, Piergiorgio; Ciamporcero, Eric; Dianzani, Mario U.; Barrera, Giuseppina

doi:10.5772/29350

Cited by 2 publications

(2 citation statements)

References 171 publications

(168 reference statements)

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“…MTX treatment in the toxic control group showed a compelling increase in the creation of MDA products and thereby the concurrence of lipid peroxidation in the MTX toxicity, which is in corroboration with previous work. 26 Concomitant administration of ALA (18 : 3, u-3) and LA (18 : 2, u-6) depreciated the levels of MDA products to a signicant level and by that curtailed oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Effect of enteral administration of α-linolenic acid and linoleic acid against methotrexate induced intestinal toxicity in albino rats

et al. 2014

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The present study was confronted to exemplify the effect of α-Linolenic acid (ALA) (18:3, ω-3) and Linoleic acid (LA) (18:2, ω-6) on experimental intestinal toxicity induced by methotrexate (MTX). The groups of albino rats received, Group I: normal saline (2 ml/kg, i.p. sham control), Group-II : MTX (2.5 mg/kg, i.p. toxic control); Group-III: ALA (2 ml/kg, i.p.); Group-IV: LA (18:2, ω-6) (2 ml/kg, i.p.), Group-V : ALA (2 ml/kg, i.p.) andGroup-VI: LA (2 ml/kg, i.p.) with MTX (2.5 mg/kg, i.p.). Animals were sacrificed after 7 days treatment schedule and appraised for intestinal pH, total acidity, free acidity and colonic mucosal disease index (CMDI). Intestinal tissues were further evaluated for oxidative stress parameters (TBARS, SOD, protein carbonyl and catalase), and morphological modulation using scanning electron microscopy. The intestinal tissues were further graded for the enzymatic activities of COX-1, COX-2 and 15-LOX. Both ALA and LA demonstrated momentous protection against MTX induced intestinal toxicity, which could be attributed to their prooxidant nature.

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Section: Discussionmentioning

confidence: 99%

Effect of enteral administration of α-linolenic acid and linoleic acid against methotrexate induced intestinal toxicity in albino rats

et al. 2014

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“…HNE is highly electrophilic molecule, which predisposes it to localize in the cell membranes. It can easily react with low molecular weight compounds, such as glutathione, with proteins and lipids [19] [20]. HNE has been shown to form Michael adducts via the C-3 atom with the sulfydryl group of Cys residues [21].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Physico-Chemical Properties of Human Kidney Cell Membranes during the Cancer Transformation

Szachowicz-Petelska¹,

Dobrzyńska²,

Figaszewski³

et al. 2014

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Kidney tissue is particularly susceptible to reactive oxygen species attack which leads to development of cancer. During oxidative stress, membrane lipids and proteins are major targets of reactive oxygen species (ROS). This work is focused on changes of phospholipids, proteins content and electric charge that occur in cell membranes of kidney cancer of pT3 stage, grade G3 and with metastasis. Qualitative and quantitative phospholipid composition and the presence of integral membrane proteins were determined by high-performance liquid chromatography. Electrophoresis was used to determine the surface charge density of the human kidney cell membrane. It was shown that the process of cancer transformation was accompanied by an increase phospholipid levels and altered the level of integral proteins as determined by decrease phenylalanine, tyrosine, cysteine and arginine. Moreover, the process of cancer transformation significantly enhanced changes in the surface charge density of the human kidney cell membrane. Cell membrane structure and function are modified by neoplasm lesion.

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Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News

Cited by 2 publications

References 171 publications

Effect of enteral administration of α-linolenic acid and linoleic acid against methotrexate induced intestinal toxicity in albino rats

Effect of enteral administration of α-linolenic acid and linoleic acid against methotrexate induced intestinal toxicity in albino rats

Changes in the Physico-Chemical Properties of Human Kidney Cell Membranes during the Cancer Transformation

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