Lipid peroxidation in chronic gastritis; any influence of Helicobacter pylori?

Giamarellos‐Bourboulis, Evangelos J.; Tzivras, Michalis; Kourtesas, Dimitris; Arnaoutis, Theodora P.; Delladatsima, Ioanna; Dionyssiou-Asteriou, Amalia; Davaris, P; Vafiadis-Zouboulis, Irene; Archimandritis, Athanasios

doi:10.1016/s0952-3278(03)00003-6

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…In contrast, another study revealed that H. pylori infection did not have significant effects on oxygen metabolism in the inhabitants of Łódź[37]. Lipid peroxidation is a mechanism involved in the pathogenesis of gastritis, whether associated or not associated with H. pylori infection[38]. However, the H. pylori CagA gene is relevant to the expression of antioxidant proteins of H. pylori[39].…”

Section: Discussionmentioning

confidence: 99%

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Wang

et al. 2015

PLoS ONE

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Different amounts of ingested alcohol can have distinct effects on the human body. However, there is limited research on chronic alcohol consumption with Helicobacter pylori infection. We sought to investigate the relationship between the cytokine profile, oxidative balance and H. pylori infection in subjects with chronic alcohol consumption. A total of 142 subjects were divided into three groups: 59 subjects with chronic alcohol ingestion and H. pylori infection (group A); 53 subjects with chronic alcohol ingestion without H. pylori infection (group B); and 30 control subjects (group C). The serum levels of CagA, interleukin (IL)-10, E-selectin, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD) activity were measured by enzyme-linked immunosorbent assay (ELISA). We found that the ages and serum H. pylori CagA levels among the three groups, as well as both the mean drinking age and the mean daily alcohol consumption between groups A and B, were matched and comparable. Comparing the BMIs among the three groups, the BMI differences were found to be statistically significant (F=3.921, P<0.05). Compared with group C, the BMIs in groups A and B were significantly higher (P<0.001 and P<0.01, respectively); however, the BMI differences between group A and group B were not statistically significant (P>0.05). Additionally, no differences in the serum CagA levels were found in comparisons among the groups (all P>0.05). The serum IL-10 and E-selectin levels in group A were significantly lower than those in group B (serum IL-10: P<0.05; E-selectin: P<0.05). The serum IL-10 in group A was significantly higher than that in group C (P<0.01); the serum E-selectin levels in group A did not significantly differ compared with those in group C (P>0.05). Furthermore, the serum IL-10 and E-selectin levels in group B were significantly higher than those in group C (serum IL-10: P<0.001; E-selectin: P<0.05); however, the serum TNF-α levels did not differ among groups (all P>0.05). Although the serum levels of MDA and SOD in groups A and B were slightly lower than those in group C, there were no significant differences among groups (all P>0.05). In conclusion, we believe that H. pylori infection might cause a significant inhibition of certain cytokine profiles in subjects with chronic alcohol ingestion. Moreover, chronically ingested alcohol may exert an adjusted inflammatory effect, but there was no association between H. pylori infection, chronic alcohol consumption and oxidative balance.

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Section: Discussionmentioning

confidence: 99%

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Wang

et al. 2015

PLoS ONE

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“…The oxidative damage caused by free radicals is believed to play a pivotal role in the pathogenesis of H pylori infection [27][28][29] . Lipid peroxidation is one of the reactions set into motion as a consequence of the formation of these radicals in cells and tissues [26] .…”

Section: Discussionmentioning

confidence: 99%

Increased plasma malondialdehyde and fructosamine in anemicH pyloriinfected patients: Effect of treatment

Vijayan

Sundaram²,

Bobby³

et al. 2007

WJG

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“…The peroxidation of polyunsaturated fatty acids and the subsequent formation of free radicals may be involved in the pathogenesis of gastritis [ 24 ]. It is well known that tissues exposed to oxidative stress contain large amounts of toxic oxygen radicals, which induce lipid peroxidation that produces MDA [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Curcuma aromaticaWater Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status

Jeon

Lee

Shin

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW) in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p < 0.01, resp.) and increased mucosal GSH content (500 mg/kg, p < 0.01) and the activity of catalase (250 and 500 mg/kg, p < 0.01, resp.). CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

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Lipid peroxidation in chronic gastritis; any influence of Helicobacter pylori?

Cited by 10 publications

References 9 publications

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Increased plasma malondialdehyde and fructosamine in anemicH pyloriinfected patients: Effect of treatment

Curcuma aromaticaWater Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status

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