Lipid peroxidation and spectrin of RBC membrane in hydroxyurea treated Eβ thalassaemia

De, Manisha; Banerjee, N.; Talukdar, Gourango; Bhattacharya, D. K.

doi:10.1007/bf02873550

Cited by 2 publications

(1 citation statement)

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“…A current clinical study in TI patients has shown HU decreased serum ferritin (50 vs. 33%), LIP (20 vs. 13%), apoptotic event (62 vs. 15%), and ROS (60 vs. 50%) levels and increased GSH level (66 vs. 25%) in the responders compared to the nonresponders [100]. In addition to the increase in Hb F synthesis, treatment with HU (30 mg/day) in β-thalassemia patients with Hb E for 3 months decreased SOD activity and MDA concentration of the RBC, probably due to inhibition of cytosolic superoxide radical and membrane lipid peroxidation [101,102].…”

Section: Hydroxyureamentioning

confidence: 99%

Diet-Related Thalassemia Associated with Iron Overload

Srichairatanakool¹,

Koonyosying²,

Fucharoen³

2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Thalassemia is an inherited disease caused by the genetic disorder of α-and β-globin genes, resulting in ineffective erythropoiesis and chronic anemia. Transfusion-dependent β-thalassemia patients require red cell transfusion to maintain their blood hemoglobin level in the normal range, whereas non-transfusion-dependent thalassemia patients increase duodenal absorption of dietary iron in an attempt to accelerate erythropoiesis. These changes give rise to iron overload, oxidative stress, organ dysfunction, and other complications. Effective iron chelators are necessary to achieve negative iron balance and to relieve such complications associated with iron overload. Some pharmaceuticals such as hydroxyurea, N-acetylcysteine, ascorbic acid, vitamin E, and glutathione are also given to thalassemia patients in order to overcome oxidative cell and tissue damage and to generate a better quality of life. Interestingly, functional natural products (such as mango, tea, caffeine, and curcumin), vegetables, and cereal (e.g., rice) are helpful for their health-providing properties by supplementing the endogenous antioxidant defensive power in the body. Natural products exhibit many pharmacological activities, but they are safer if used in the traditional manner.

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Section: Hydroxyureamentioning

confidence: 99%