Lipid peroxidation and platelet membrane fluidity—implications for Alzheimerʼs disease?

Rensburg, Susan J. van; Daniels, Willie M. U.; Zyl, Johann van; Potocnik, Felix; Walt, B. J. Van Der; Taljaard, J. J. F.

doi:10.1097/00001756-199411000-00004

Cited by 24 publications

(9 citation statements)

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“…Our studies in Al-loaded cultured cells and in red blood cells of hemodialysis patients suggest that lipid peroxidation may be an important mechanism of Al toxicity [1,2,13]. In addition, in vitro and in vivo studies with the antioxidants melatonin and vitamin E have been shown to mitigate Al toxicity [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants prevent aluminum-induced toxicity in cultured hepatocytes

Abreo

Sella

Alvarez-Hernandez

et al. 2004

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

Antioxidants prevent aluminum-induced toxicity in cultured hepatocytes

Abreo

Sella

Alvarez-Hernandez

et al. 2004

Journal of Inorganic Biochemistry

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“…Since ALB is involved with fatty acid transport, any decrease in ALB con‐centration could jeopardize the availability of fatty acids for incorporation into cell membranes. Lipid peroxidation of cell membranes may play an important role in the etiology of AD 11 …”

Section: Discussionmentioning

confidence: 99%

The Effect of Iron and Aluminum on Transferrin and Other Serum Proteins as Revealed by Isoelectric Focusing Gel Electrophoresis

Rensburg

Carstens

Potocnik

et al. 2000

Annals of the New York Academy of Sciences

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“…6 This led to the hypothesis that AD may result from free radical-induced lipid peroxidation of neuronal membranes. 5 The iron binding capacity of TfC2 in vitro was found to be decreased in one study 7 and unchanged in another. 4 Apolipoprotein E (ApoE), on the other hand, is involved in the transport and redistribution of membrane lipids, and may thus play a part in the regeneration of damaged membranes.…”

Section: Introductionmentioning

confidence: 92%

“…It was previously demonstrated that an increased frequency of TfC2 may be involved in other diseases thought to be caused by free radical damage, such as rheumatoid arthritis and phototoxic eczema 6. This led to the hypothesis that AD may result from free radical‐induced lipid peroxidation of neuronal membranes 5. The iron binding capacity of TfC2 in vitro was found to be decreased in one study 7 and unchanged in another 4…”

Section: Introductionmentioning

confidence: 99%

“…An additional function of Tf is to inhibit free radical reactions by removing iron from the Fenton reaction, thereby inhibiting the production of hydroxyl radicals, which are in turn responsible for damage to cell membranes by lipid peroxidation. 5 It was previously demonstrated that an increased frequency of TfC2 may be involved in other diseases thought to be caused by free radical damage, such as rheumatoid arthritis and phototoxic eczema. 6 This led to the hypothesis that AD may result from free radical-induced lipid peroxidation of neuronal membranes.…”

Section: Introductionmentioning

confidence: 99%

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Earlier Age of Onset of Alzheimer's Disease in Patients with Both the Transferrin C2 and Apolipoprotein E‐ɛ4 Alleles

Rensburg

Potocnik

Villiers

et al. 2000

Annals of the New York Academy of Sciences

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The etiology of Alzheimer's disease is now known to be multifactorial. The genetic factors transferrin C2 (TfC2) and apolipoprotein E epsilon 4 (ApoE-epsilon 4) have both been associated with Alzheimer's disease (AD). Transferrin is the carrier protein for iron in the blood, while ApoE is involved with the transport and redistribution of lipids. In the present study, the polymerase chain reaction (PCR) method was used to determine the frequency of both TfC2 and ApoE-epsilon 4 in 27 AD patients, 9 vascular dementia (VaD) patients, and 27 controls. Patients were diagnosed according to the criteria as set out in the 4th edition of the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV). The frequency of the TfC2 allele for the AD patients was 24%, while for the VaD patients it was 12.5%, which was not significantly different from the controls at 13%. The frequency of ApoE-epsilon 4 for the AD patients was 44%, for the VaD patients 22%, and controls 17%. Of the 27 AD patients, 8 had both TfC2 and ApoE-epsilon 4. The age of onset of the disease in these 8 patients (51-67 years, mean 60.25) was significantly earlier (p < 0.02) than in the remaining AD patients (49-76 years, mean 66.9). None of the VaD patients had both the TfC2 and the ApoE-epsilon 4 alleles.

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Lipid peroxidation and platelet membrane fluidity—implications for Alzheimerʼs disease?

Cited by 24 publications

References 0 publications

Antioxidants prevent aluminum-induced toxicity in cultured hepatocytes

Antioxidants prevent aluminum-induced toxicity in cultured hepatocytes

The Effect of Iron and Aluminum on Transferrin and Other Serum Proteins as Revealed by Isoelectric Focusing Gel Electrophoresis

Earlier Age of Onset of Alzheimer's Disease in Patients with Both the Transferrin C2 and Apolipoprotein E‐ɛ4 Alleles

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