Lipid Peroxidation and Enzymatic Antioxidants among Breast Cancer Women of African Descent in Sokoto, Nigeria

Yeldu, Mohammed Haruna; Jibrin, A; Ngaski, A. A.; Bashir, Mohamed Al; Mainasara, A; Sani, Behzad; Wasagu, I; Aminu, G

doi:10.9734/arrb/2017/34672

Cited by 1 publication

(3 citation statements)

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“…Similarly, a previous report [50] reported significantly decreased antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and vitamins (vitamin C and vitamin E) in the patients with benign prostate hyperplasia and prostate cancer when compared with the control group (p < 0.005). In another study [18], an increased lipid peroxidation with decreased antioxidant status was observed among breast cancer patients of African Descent in Sokoto, Nigeria. Similarly, a previous report [51] proved that the antioxidant capacity of plasma in chronic obstructive pulmonary disease patients increased about 2 folds as compared with normal subjects measured using the ferric reducing ability of plasma assay.…”

Section: Yes Nomentioning

confidence: 88%

“…In both patients suffering from lung cancer as well as glaucoma, the concentration of MDA is high; thereby validating the reliability of MDA assay to find out oxidative stress in relation to pathology of various diseases [16] [17]. A Study in a tertiary hospital in Nigeria reported lipid peroxidation with a decrease in antioxidant activity [18] among breast cancer patients.…”

Section: Introductionmentioning

confidence: 93%

“…Other ethnic groups resident in the area Igbo, Yoruba, Nupe, Ebira, Igala, etc. It has 23 local government areas (LGAs), Five (5) of which are urban and eighteen (18) rural LGAs. The classification of urban rural areas in the state is by the National Population Commission based on a location of 16km radius from the centre of the state.…”

Section: Background Of the Study Areamentioning

confidence: 99%

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Some Oxidative Stress Biomarkers among Patients with Prostate Cancer in Sokoto, North Western Nigeria

Erhabor¹,

Hussaini²,

Abdulwahab-Ahmed³

et al. 2022

OJBD

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Globally, prostate cancer (PCa) is the most common malignancy and the second leading cause of cancer-related death in men. It is a significant contributor to the burden of diseases and affects over a million men. This study investigated the levels of malondialdehyde and plasma total antioxidant capacity among patients with prostate cancer in Sokoto. This case-control study was conducted among 28 confirmed prostate cancer patients attending the Urology clinics in Usmanu Danfodiyo University Teaching Hospital and Sokoto Specialist Hospital in North Western Nigeria. Twenty-eight age-matched healthy males were monitored as controls. Determination of Total Antioxidant Capacity (TAC) was determined using Ferric Reducing Antioxidant Power (FRAP) reagent while the Malondialdehyde in serum was determined as a conjugate with Thiobarbituric acid (TBA) acid. Data were collected using a semi-structured interviewer-administered questionnaire. Data were processed using SPSS version 20 and results were reported as Mean ± Standard deviation. The malondialdehyde level was significantly increased (p < 0.0001) among subjects with prostate cancer (0.215 ± 0.06) compared to controls (0.073 ± 0.04). The plasma total antioxidant capacity decreased significantly among the subjects (247.9 ± 63.3) compared to controls (743.3 ± 104.40) (p < 0.0001). The findings from this indicated a high Malondialdehyde (lipid peroxidation indicator) and low levels of Total Antioxidant Capacity among prostate cancer patients as evidence of redox imbalance. Subjects in monogamous relationships compared to polygamous, rural dwellers, farmers, individuals of Hausa ethnicity and subjects who reported no family history of the disease were more predisposed to prostate cancer.

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Section: Yes Nomentioning

confidence: 88%