Lipid Peroxidation and Antioxidative Enzyme Activities in Childhood Epilepsy

Türkdoğan, Dilşad; Toplan, Selmin; Karakoç, Yunus

doi:10.1177/088307380201700904

Cited by 40 publications

(29 citation statements)

References 13 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, erythrocyte GR and plasma ascorbate and vitamin A concentrations were lower [79]. In the majority of these studies also increased markers of lipid peroxidation were noted [75,[77][78][79][80][81][82].…”

Section: Influence Of Aeds On Antioxidants and Markers Of Oxidative Smentioning

confidence: 89%

“…Increased activities of SOD [75,76] and CAT [75,77], and decreased activities of GPX [75,78] and glutathione reductase (GR) [79] was observed in numerous studies in drug-naive patients with epilepsy. In a recent study, LP and percentage haemolysis in patients with epilepsy was higher compared to controls [79].…”

Section: Influence Of Aeds On Antioxidants and Markers Of Oxidative Smentioning

confidence: 99%

“…On the other hand, there are also studies, with very weak (unchanged SOD, CAT, GPX and GR activities) [78,79,[82][83][84] or even opposite (decreased lipid peroxidation markers) [85] association of oxidative stress with epilepsy.…”

Section: Influence Of Aeds On Antioxidants and Markers Of Oxidative Smentioning

confidence: 99%

See 2 more Smart Citations

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

Martinc¹,

Grabnar²,

Vovk³

2012

Current Neuropharmacology

View full text Add to dashboard Cite

Abstract:Epilepsy is considered one of the most common neurological disorders. The focus of this review is the acquired form of epilepsy, with the development process consisting of three major phases, the acute injury phase, the latency epileptogenesis phase, and the phase of spontaneous recurrent seizures. Nowadays, an increasing attention is paid to the possible interrelationship between oxidative stress resulting in disturbance of physiological signalling roles of calcium and free radicals in neuronal cells and mitochondrial dysfunction, cell damage, and epilepsy. The positive stimulation of mitochondrial calcium signals by reactive oxygen species and increased reactive oxygen species generation resulting from increased mitochondrial calcium can lead to a positive feedback loop. We propose that calcium can pose both, physiological and pathological effects of mitochondrial function, which can lead in neuronal cell death and consequent epileptic seizures. Various antiepileptic drugs may impair the endogenous antioxidative ability to prevent oxidative stress. Therefore, some antiepileptic drugs, especially from the older generation, may trigger oxygen-dependent tissue injury. The prooxidative effects of these antiepileptic drugs might lead to enhancement of seizure activity, resulting in loss of their efficacy or apparent functional tolerance and undesired adverse effects. Additionally, various reactive metabolites of antiepileptic drugs are capable of covalent binding to macromolecules which may lead to deterioration of the epileptic seizures and systemic toxicity. Since neuronal loss seems to be one of the major neurobiological abnormalities in the epileptic brain, the ability of antioxidants to attenuate seizure generation and the accompanying changes in oxidative burden, further support an important role of antioxidants as having a putative antiepileptic potential.

show abstract

Section: Influence Of Aeds On Antioxidants and Markers Of Oxidative Smentioning

confidence: 89%

Section: Influence Of Aeds On Antioxidants and Markers Of Oxidative Smentioning

confidence: 99%

See 1 more Smart Citation

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

Martinc¹,

Grabnar²,

Vovk³

2012

Current Neuropharmacology

View full text Add to dashboard Cite

show abstract

“…In addition, epilepsy may be associated with neurodegeneration, presumably due to abnormal lipid peroxidation. 1,2 On the other hand, comorbid depression is common in patients with epilepsy. A review of available studies 3 suggested a high prevalence of mood (affective) disorders, especially major depression (8%-48%), followed by anxiety (5%-32%), in patients with epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Combination of valproate and paroxetine in mice exposed to picrotoxin

Kamal¹

2012

IJN

View full text Add to dashboard Cite

Abstract:The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhibitor) administered alone or in combination with the antiepileptic drug sodium valproate on chemoconvulsions induced by picrotoxin (PTX). Seizure score was recorded in vivo, and the levels of thiobarbituric acid-reactive substances and gamma aminobutyric acid (GABA) were measured in the nucleus accumbens of the tested groups of mice. The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate. On the other hand, paroxetine administered in combination with sodium valproate provided significant protection against PTX-induced convulsions as well as a significant increase in GABA levels in selected brain areas. These results favor their application in management of epilepsy-depression comorbidities.

show abstract

“…In addition epilepsy may be associated with neuro-degeneration presumably due to abnormal lipid per oxidation [1,2]. On the other hand, co-morbid depression is common in patients with epilepsy.…”

mentioning

confidence: 99%

Possible Anti-Anhedonic Effect of Valproate in Mice Exposed to Chronic Mild Stress model

El-Dine¹

2013

J Neurol Disord

View full text Add to dashboard Cite

Epilepsy is one of the most common neurological disorders characterized by recurring excessive neuronal discharge, exhibited by transient episodes of motor, sensory, or psychic dysfunction, with or without unconsciousness or convulsive movements. In addition epilepsy may be associated with neuro-degeneration presumably due to abnormal lipid per oxidation [1,2]. On the other hand, co-morbid depression is common in patients with epilepsy. A review of available studies [3] suggested a high prevalence of mood (affective) disorders especially major depression (8%-48%) followed by anxiety (5%-32%) in patients with epilepsy.Can the antiepileptic drug, sodium valproate induce beneficial effects on reduction in sucrose consumption and immobility in forced swimming test of stressed anhedonic albino mice. Additionally, can it has the ability to increase the activity of important anti-oxidant enzymes in hippocampus of these mice that would help in stopping the oxidative stress related to mood disorders.Actually, these effects could have a contributing role in control of convulsions in stressed mice according to literature [4]. Accordingly, these questions need an evaluation of sucrose consumption and duration of immobility after exposure to CMSmodel for 6 weeks and forced swimming test respectively in mice treated with the anti-epileptic drug sodium valproate (administered in the last 3 weeks of the model) and compare the results with that obtained from stressed untreated albino mice.Besides the above measured parameters, there is a strong need to measure the activities of the selected antioxidant enzymes catalase and glutathione peroxidase enzymes in hippocampus after 3-weeks of administration of the tested drug to the tested mice [5,6].However, valproate exerted an inhibitory effect on DA-induced hyperactivity similar to that produced by GABA. GABA plays an important role in depressed mood as its reduction in CSF was reported in depressed patients and elevated when these patients were treated with selective serotonin reuptake inhibitors. These findings may suggest a possible beneficial role of valproate in improving depressed mood [7,8]. However, in earlier studies, valproate was injected into the nucleus accumbens and its effect on GABAergic enzymes was controversial [9]. These results open the way to further investigations to reach a proper and well-defined conclusion.

show abstract

Lipid Peroxidation and Antioxidative Enzyme Activities in Childhood Epilepsy

Cited by 40 publications

References 13 publications

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress

Combination of valproate and paroxetine in mice exposed to picrotoxin

Possible Anti-Anhedonic Effect of Valproate in Mice Exposed to Chronic Mild Stress model

Contact Info

Product

Resources

About