Lipid peroxidation and antioxidant status in colorectal cancer

Abstract

Colorectal carcinogenesis is associated with serious oxidative stress and confirms that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer.

Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions

“…Although our results confirm the previous findings, we observed a sharp increase in lipid peroxide adducts in stage IV of CRC. Our results are also in agreement with the reported deployment in stage IV CRC of nonenzymatic antioxidants such as GSH and vitamins C and E [41].…”

“…The transcriptional responses of ROS-dependent genes parallel or oppose ApoD expression changes throughout the stages of CRC We observe a general upregulation of antioxidant gene expression when comparing CRC and control tissues, as it has been previously described [41,46]. It accounts for the timely cell response to cope with the increasing levels of oxidative stress generated by the abnormal proliferation of cancerous cells.…”

“…An increase in lipid peroxidation, both in blood and cancerous tissue samples, has been previously reported in primary CRC patients [39][40][41]. In particular, Skrzydlewska et al [41] found a steady increase of the lipid peroxide adduct MDA in malignant tissue of stages II-IV and a sustained increase in 4-HNE. Although our results confirm the previous findings, we observed a sharp increase in lipid peroxide adducts in stage IV of CRC.…”

Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice

“…One hypothesis is that it does so via antioxidant activity. Recent studies indicate that a high level of catalase expression could be associated with less genetic damage, thereby reducing the risk of CRC 29 and the oxidative stress generated by DMH. However, we observed no difference in the expression of catalase in the liver and intestine following the treatments.…”

The Caudal-Related Homeodomain Proteins Upregulate catalase Expression in Drosophila Hindgut and Human Colorectal Carcinoma Cells

“…Recently, it was reported that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer [34]. In considering a critical function for oxidative stress in progression of colorectal cancers, regulation of the activities of H2O2 metabolizing enzymes, such as superoxide dimutase (SOD), catalase and glutathione peroxidase (GPx) are likely to be required [34]. Among the anti-oxidants, catalase is a heme-containing peroxisomal enzyme and protects the H2O2 generated in normal human tissues [27].…”