Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease

Gönenç, Aymelek; Erten, Derya; Aslan, Sabahattin; Akıncı, Melih; Şimşek, Bolkan; Torun, Meral

doi:10.1016/j.cellbi.2006.02.005

Cited by 129 publications

(66 citation statements)

References 31 publications

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“…The higher TAO activities in our study may be due to the response of increased ROS production and excessive antioxidant consumption with inability to detoxify high levels of H 2 O 2 into H 2 O that results in the formation of the most dangerous OH -radical followed by MDA and development of oxidative stress. This finding was in agreement with Gönenc et al [47], who investigated 15 breast cancer cases and 15 controls and showed that TAO level, was elevated in the breast cancer patient group compared to control group. The apoptotic profile in our study was also investigated by estimation of circulating levels of sFas "as inhibitor of apoptosis".…”

Section: Discussionsupporting

confidence: 92%

Correlations of circulating levels of oxidants, antioxidants and soluble Fas in breast cancer among Egyptian females

Madboly

El-Bawab

El-Ebidi

et al. 2016

IJBAS

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Background: Breast cancer is the first most common malignancy in Egyptian females. Oxidative stress is considered to be involved in the pathophysiology of all cancers, especially breast cancer. An inappropriately low rate of apoptosis can give rise to cancer. Objectives: The purpose of this study was to asses, compare and correlate the circulatory levels of some oxidants (malondialdehyde "MDA" and nitric oxide "NO"), total antioxidant capacity "TAO") and soluble form of Fas "sFas" in some Egyptian females having breast cancer. Methods: A cross sectional case/control study conducted on 50 Egyptian females recruited from outpatient clinics or inpatients department of the general surgery at Sohag university hospital, divided into 30 females with malignant breast lesion and 20 healthy females as a control group. Colorimetric assay of serum levels of NO, MDA and TAO, while, sFas was determined using ELISA method. Results: There were significant high levels of NO, MDA, TAO and sFas in malignant group than in control group with p-value < 0.0001, high positive correlation between NO, MDA, TAO and sFas in malignant group ( r= 0.958, 0.807, 0.748 respectively and P< 0.0001 for all). There was high positive correlation between NO and TAO in malignant group (r = 0.78, P < 0.0001).There was also, high positive correlation between MDA and TAO in malignant group (r = 0.81, P < 0.0001). Conclusion: These results support the oxidative stress hypothesis and resistance to apoptosis in development and progression of breast cancer.

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Section: Discussionsupporting

confidence: 92%

Correlations of circulating levels of oxidants, antioxidants and soluble Fas in breast cancer among Egyptian females

Madboly

El-Bawab

El-Ebidi

et al. 2016

IJBAS

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“…The amount of nitrite is also elevated in breast tissue from breast cancer patients (745 nmol/g wet weight) compared with the amount in benign breast disease (442 nmol/g wet weight; ref. 36). In breast tumors, the expression of NOS is associated with increased proliferation and tumor grade and the expression of PgR and nitric oxide is associated with invasive disease (37).…”

Section: Discussionmentioning

confidence: 99%

Activation of Estrogen Receptor-α by the Anion Nitrite

Veselik¹,

Divekar²,

Dakshanamurthy³

et al. 2008

Cancer Research

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In this study, the ability of nitrite and nitrate to mimic the effects of estradiol on growth and gene expression was measured in the human breast cancer cell line MCF-7. Similar to estradiol, treatment of MCF-7 cells with either 1 Mmol/L nitrite or 1 Mmol/L nitrate resulted in f4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. The anions also recruited estrogen receptor-A (ERA) to the pS2 promoter and activated exogenously expressed ERA when tested in transient cotransfection assays. To determine whether nitrite or nitrate was the active anion, diphenyleneiodonium was used to inhibit oxidation/reduction reactions in the cell. The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERA suggests that nitrite is the active anion. Concentrations of nitrite, as low as 100 nmol/L, induced a significant increase in PgR mRNA, suggesting that physiologically and environmentally relevant doses of the anion activate ERA. Nitrite activated the chimeric receptor Gal-ER containing the DNA-binding domain of GAL-4 and the ligand-binding domain of ERA and blocked the binding of estradiol to the receptor, suggesting that the anion activates ERA through the ligand-binding domain. Mutational analysis identified the amino acids Cys381, His516, Lys520, Lys529, Asn532, and His547 as important for nitrite activation of the receptor. [Cancer Res 2008;68(10):3950-8]

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“…27 The TC and HDL values were elevated in patients with BBD as compared with breast cancer patients, but LDL and TG levels were comparable between the 2 groups. 28 Kokoglu et al 29 showed significant increases in TG and VLDL and decreases in total, HDL, and LDL cholesterol levels. In contrast, Farid et al 30 showed higher levels of cholesterol and TG in breast cancer patients.…”

Section: Discussionmentioning

confidence: 97%

Significance of Alterations in Plasma Lipid Profile Levels in Breast Cancer

et al. 2008

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Emphasizing the critical role of oxidative stress in the etiology of breast cancer, numerous reports have demonstrated that reactive oxygen species (ROS) are capable of oxidizing cell constituents such as DNA, proteins, and lipids, thereby incurring oxidative damage to cell structures. 7,8 Excessive oxidation leads to impairment of cell functions and development of morbid conditions. 9-11 ROS directly attack lipids, which leads to the peroxidation of polyunsaturated fatty acids (PUFA). Lipid hydroperoxides derived from the PUFA are prominent intermediates of peroxidative reactions. They may undergo reductive degradations, which can either diminish or enhance cytotoxic potentials, depending on the severity of stress. In addition, the lipid hydroperoxides or related intermediates trigger signal transduction pathways calling for either greater cytoprotection (upregulation of detoxifying enzymes) or deliberate termination (apoptotic death). 12B reast cancer is a major contributor to the overall international cancer burden.1 In India, it is the second leading malignancy in women.2 In our institution, breast cancer is a major female malignancy, with an annual incidence rate of 20% of all cancer cases. The etiology of breast cancer is multifactorial.4,5 However, the exact cause of breast cancer is still obscure because the disease presumably represents a complex interplay of genetic susceptibility and environmental factors. were analyzed from 70 controls, 30 patients with benign breast disease (BBD), 125 untreated breast cancer patients, and 93 posttreatment follow-up samples. Methods. Samples were analyzed using highly sensitive and specific spectrophotometric methods. Results. Plasma TC, LDL, VLDL, and TG were significantly lower (p = .042, p = .003, p = .024, p = .014, respectively) in patients with BBD compared with controls. Plasma TC and HDL were significantly lower (p = .026, p = .0001, respectively), and VLDL and TG were significantly higher (p = .009, p = .05) in breast cancer patients as compared with controls. Plasma VLDL and TG were significantly higher in breast cancer patients as compared with patients with BBD. The receiver-operating characteristic curve showed that plasma TC, LDL, VLDL, and TG levels could significantly discriminate (p = .001, p = .005, p = .005, p = .005, respectively) between controls and patients with BBD. Plasma levels of TC, HDL, VLDL, and TG could significantly distinguish (p = .01, p = .002, p = .001, p = .002, respectively) between controls and breast cancer patients. Plasma levels of VLDL and TG could significantly discriminate (p = .000, p = .000, respectively) between patients with BBD and breast cancer patients. Odds ratio analysis revealed that higher levels of TC and HDL were significantly associated with a reduction in breast cancer risk (p = .01 and p = .0001, respectively), whereas higher levels of VLDL and TG were significantly associated with increased breast cancer risk (p = .001 and p = .002, respectively). Plasma VLDL and TG levels were significantly lower in compl...

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Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease

Cited by 129 publications

References 31 publications

Correlations of circulating levels of oxidants, antioxidants and soluble Fas in breast cancer among Egyptian females

Correlations of circulating levels of oxidants, antioxidants and soluble Fas in breast cancer among Egyptian females

Activation of Estrogen Receptor-α by the Anion Nitrite

Significance of Alterations in Plasma Lipid Profile Levels in Breast Cancer

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