Lipid Peroxidation and Antioxidant Status in Stomach Cancer

Abstract

We conclude that increased MDA levels and decreased antioxidant enzyme activities can be valuable parameters in assessing the possible risk of cancer.

Oxidative Products of Proteins and Antioxidant Potential of Thiols in Gastric Carcinoma Patients

“…The present study is in agreement with the studies done on gastric cancer antioxidant status by Batcio gluk et al (8), Arivazhagan et al (10), Dincer (21,22) and also studies done on inflam matory bowel disease (23), colorectal cancer (24,25) and bladder cancer (26). Thus, the results of the present study are in accord with those of previous studies.…”

“…Several recent studies done by Ebubekir et al (7) and Batcioglu et al (8), point out the role of oxidative stress in gastric cancer. It is known that free radicals cause protein damage and degradation (2).…”

Nutritional Supplements for Cancer-Associated

“…Excess oxidative stress (or primarily its mediators-excess ROS/RNS) within cancer cells has been linked to promotion and progression of malignancy of cancers (Brown & Bicknell, 2001;Klaunig & Kamendulis, 2004;Ray et al, 2000;Tas et al, 2005;Toyokuni et al, 1995). Thus oxidative stress and antioxidant status have been examined in various malignant cancers, such as breast (Brown & Bicknell, 2001;Kang, 2002;Ray et al, 2000;Tas et al, 2005), prostate (Aydin et al, 2006;Sikka, 2003), colorectal (Otamiri & Sjodahl,1989;Oxdemirler et al, 1989), renal (Asal et al, 1990;Gago-Dominguez et al, 2002), and other malignancies (Batcioglu et al, 2006;Manoharan et al, 2005;Seril et al, 2003). In all of these cancers ROS/RNS were in excess of antioxidant concentrations, resulting in cellular oxidative stress.…”

“…In cancer patients mitochondrial membranes as well as other cellular membranes are especially sensitive to oxidative damage by ROS/RNS, which occurs at high rates in cancer (Batcioglu et al, 2006;Dianzani, 1993;Gago-Dominguez et al, 2002;Manoharan et al, 2005;Otamiri & Sjodahl, 1989;Oxdemirler et al, 1989;Seril et al, 2003). Oxidation of membrane phospholipids alters their structure, affecting lipid fluidity, permeability and membrane function (Dianzani, 1993;Nicolson et al, 1977;Subczynski & Wisniewska, 2000).…”

Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors

“…In previous studies, it has been demonstrated that ROS are directly suggested in oxidative damage of cellular macromolecules such as lipids, proteins, and nucleic acids in tissues (6). Moreover, oxidative stress can lead to tumor angiogenesis.…”