Lipid Peroxidation and Antioxidant Defense Systems in Liver of Rats in Chronic Fluoride Toxicity

Shivashankara, AR; Shivarajashankara, YM; Bhat, Pallavi; Rao, S. Hanumanth

doi:10.1007/s001280298

Cited by 61 publications

(73 citation statements)

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“…[20] In this study,it is seen that administration of fluoride to rats caused a significant increase in the level of lipid peroxidation as indicated by the significant increase in MDA. Our results also corroborate well with that of Shivarajashankara et al [21] who demonstrated that 100 ppm of fluoride increases the rate of lipid peroxidation in liver.…”

Section: Haematological Parameterssupporting

confidence: 93%

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

Derouiche¹

2017

WJPPS

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Section: Haematological Parameterssupporting

confidence: 93%

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

Derouiche¹

2017

WJPPS

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“…Therefore, in line with the results of earlier reports, it could be suggested that the elevated lipid peroxidation in fluorosis may result from the decreased activities of antioxidant enzymes [32][33][34]. There have been many reports suggesting that free radicals play an aberrant role in the mechanism of fluoride toxicity [35][36][37]. High lipid content in the brain is responsible for the vulnerability of these tissues to oxidative stress.…”

Section: Discussionsupporting

confidence: 65%

Evaluation of Fluoride-Induced Oxidative Stress in Rat Brain: A Multigeneration Study

Basha

Rai

Begum³

2010

Biol Trace Elem Res

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Multigenerational evaluation was made in rats on exposure to high fluoride (100 and 200 ppm) to assess neurotoxic potential of fluoride in discrete areas of the brain in terms of lipid peroxidation and the activity of antioxidant enzyme system. The rats were given fluoride through drinking water (100 and 200 ppm) and maintained subsequently for three generations. Fluoride treatment significantly increased the lipid peroxidation and decreased the activity of antioxidant enzymes viz, catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione level in first-generation rats and these alterations were more pronounced in the subsequent second and thirdgeneration rats in both the doses tested. Decreased feed and water consumption, litter size and organ (brain) somatic index, marginal drop in body growth rate and mortality were observed in all three generations. Decreased antioxidant enzyme activity and increased malondialdehyde levels found in the present study might be related to oxidative damage that occurs variably in discrete regions of the brain. Results of this study can be taken as an index of neurotoxicity in rats exposed to water fluoridation over several generations.

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“…36 Yüksek dozda (30-500ppm) uzun süre flor alımını içeren hayvan çalışmaları sonuçlarına dayandırılarak insanlarda da uzuvlarda paraliz, vertigo, eklemlerde spastisite ve mental keskinlikte bozulma gibi nörolojik komplikasyonların olabileceği yönünde değerlendirmeler yapılmıştır. 32,36,37 Ancak bu hayvan çalışmalarında deney grubu hayvanları tarafından tüketilen flor dozu insanlar için optimal olarak belirtilen dozun çok üstündedir. Hayvanlardan elde edilen histolojik bulgularda; beyin yarım küresinde, beyincik ve medulla oblongata bölgesinde DNA, RNA ve proteinde doza bağlı belirgin azalma bulunmuştur.…”

Section: Florun Genel Sağlık üZerine Etkileriunclassified

Does Fluoride Have Negative Impact on Human Health?

Ergın¹,

Eden²

2017

EÜ Dişhek Fak Derg

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ÖZETFlor, minede demineralizasyonu inhibe eder ve remineralizasyonu destekler. Sistemik veya topikal olarak uygulanan flor ile asit ataklarına dirençli florapatit veya florhidroksilapatit ve kalsiyum-florür oluşumu gerçekleşmektedir. Florun sistemik uygulamasında suyun, tuzun, sütün florlanması, flor tabletleri, damlaları, topikal uygulamasında ise florlu diş macunları, gargaraları, flor jelleri ve vernikler kullanılmaktadır. Flor esas etkinliğini topikal uygulama sonrasında tükürükte ve plakta düşük miktarlarda bulunduğunda göstermektedir. Tek seferde ve toksik doz olarak kabul edilen 5 mg/kg flor alımı akut flor toksisitesine, optimal dozdan biraz daha yüksek, uzun süreli flor alınması kronik flor toksisitesine sebep olmaktadır. Kronik flor toksisitesinde dental florozis ve iskeletsel florozis görülebilmektedir. Florun kemikte birikimiyle iskeletsel deformasyon, büyümede gerilik ortaya çıkabilirken, yüksek miktarlarda kullanımı sonrasında karaciğer, böbrek, beyin ve beyincik gibi yumuşak dokularda da birikim ve zararlı etkiler oluşabilmektedir. Hayvan çalışmalarında florun yüksek dozlarda kullanımı sonrasında santral sinir sisteminde nörodejeneratif değişiklikler gösterilmiştir. Doğal içme sularında yüksek flor bulunan Hindistan, Çin gibi ülkelerde yüksek flor seviyesi ile düşük IQ'nun ilişkilendirildiği çalışmalarda zeka seviyesi (IQ)'ni etkileyen diğer faktörlerin değerlendirilmesindeki eksiklik güvenirlikleri açısından şüpheler doğurmaktadır. Bu derlemede, sistemik ve topikal flor uygulaması sonrası kan değerleri ve dolayısıyla dokularda birikimin farklılığı da dikkatle alınarak florun insan sağlığı üzerine etkileri irdelenmektedir. Anahtar Kelimeler: flor, dental florozis, akut toksisite, kronik toksisite, zeka ABSTRACT Fluoride inhibits demineralization and promotes remineralization in enamel. Acid resistant fluorapatite, fluorhydroxyapatite, calcium-fluoride formations are seen after systemic or topical fluoride applications. Water, salt and milk fluoridation, tablets, drops are used for systemic; toothpastes, rinses, varnish, gels are used for topical administration. Fluoride shows its main activity when found in low levels in saliva and plaque after topical application. 5 mg/kg fluoride uptake is considered as toxic dose, taking long term slightly higher doses then optimal fluoride leads to chronic fluoride toxicity. Dental and skeletal fluorosis can be seen in chronic toxicity. Skeletal deformation, growth retardation occurs with bone accumulation and accumulation and adverse effects may occur in soft tissues like liver, kidney, brain and cerebellum.Neurodegenerative changes in the central nervous system has been shown in animal studies. Studies that associated high fluoride consumption and low Intelligence Quotient (IQ) levels were performed in countries like India, China with high fluoride in natural drinking water where the deficiencies in evaluating other factors in these studies doubt their reliability. Blood values and,therefore the differences in the accumulation in tissues after systemic and t...

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Lipid Peroxidation and Antioxidant Defense Systems in Liver of Rats in Chronic Fluoride Toxicity

Cited by 61 publications

References 0 publications

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

Study of Fluoride-Induced Haematological Alterations and Liver Oxidative Stress in Rats

Evaluation of Fluoride-Induced Oxidative Stress in Rat Brain: A Multigeneration Study

Does Fluoride Have Negative Impact on Human Health?

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