Lipid peroxidation: A possible factor in late graft failure of coronary artery bypass grafts

Reduction of Lipid Peroxidation with Intraoperative Superoxide Dismutase Treatment Decreases Intimal Hyperplasia in Experimental Vein Grafts

“…Measurement of MDA, an endproduct derived from the breakdown of polyunsaturated fatty acids and related esters, provides a useful index of lipid peroxidation [7,23,24]. Piotrowski et al [5] reported higher tissue lipid peroxidation in vein grafts, which were explanted from patients undergoing repeat coronary artery bypass surgery or orthotopic heart transplant, as compared to saphenous veins, nonatherosclerotic coronary arteries, and aortas explanted from human subjects. Our finding of increased MDA concentration in 3-day vein grafts (as compared to the ungrafted jugular veins) further suggests that lipid peroxidation is augmented early with bypass surgery.…”

“…Oxidative stress including lipid peroxidation has been implicated in the initiation and progression of atherosclerosis and of vein graft failure [5][6][7]. Accumulating evidence suggests that oxidative stress plays a key role in the development of intimal hyperplasia, including the reduction of intimal hyperplasia in vein grafts with desferrioxamine (a free radical scavenger) treatment and direct in vitro stimulation of vascular smooth muscle cell proliferation by reactive oxygen species [1, 3, 4, 8 -10].…”

Mechanism of Dacron-activated monocytic cell oxidation of low density lipoprotein

“…17 A single study suggests that failed human vein grafts have elevated levels of lipid peroxides. 18 Because LDL is preferentially deposited at graft anastomoses, 5,7 anastomotic sites may be particularly prone to the accumulation of oxidized lipids and lipoproteins, but the role of oxidized lipids in graft failure has not been investigated.…”