“…Measurement of MDA, an endproduct derived from the breakdown of polyunsaturated fatty acids and related esters, provides a useful index of lipid peroxidation [7,23,24]. Piotrowski et al [5] reported higher tissue lipid peroxidation in vein grafts, which were explanted from patients undergoing repeat coronary artery bypass surgery or orthotopic heart transplant, as compared to saphenous veins, nonatherosclerotic coronary arteries, and aortas explanted from human subjects. Our finding of increased MDA concentration in 3-day vein grafts (as compared to the ungrafted jugular veins) further suggests that lipid peroxidation is augmented early with bypass surgery.…”