Lipid‐PEG‐Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two‐Photon Fluorescence Imaging

Geng, Junlong; Li, Kai; Ding, Dan; Zhang, Xinhai; Qin, Wei; Liu, Jianzhao; Tang, Ben Zhong; Liu, Bin

doi:10.1002/smll.201200814

Cited by 142 publications

(127 citation statements)

References 48 publications

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“…Substitution can take place at positions 2 and 6, generating a D-π-A or D-π-A-π-D structure. 4H-Pyran-4-ylidene derivatives are widely used in organic light-emitting diodes 9 , fluorescence bioimaging 8b, 8c, 10 , and pH sensors 11 . A fluorene-based di-substituted 4H-pyran-4-ylidene derivative was reported with good solubility in organic solvents.…”

Section: Introductionmentioning

confidence: 99%

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

et al. 2015

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Observation of the activation and inhibition of angiogenesis processes is important in the progression of cancer. Application of targeting peptides, such as a small peptide that contains adjacent L-arginine (R), glycine (G) and L-aspartic acid (D) residues can afford high selectivity and deep penetration in vessel imaging. To facilitate deep tissue vasculature imaging, probes that can be excited via two-photon absorption (2PA) in the near-infrared (NIR) and subsequently emit in the NIR are essential. In this study, the enhancement of tissue image quality with RGD conjugates was investigated with new NIR-emitting pyranyl fluorophore derivatives in two-photon fluorescence microscopy. Linear and nonlinear photophysical properties of the new probes were comprehensively characterized; significantly the probes exhibited good 2PA over a broad spectral range from 700–1100 nm. Cell and tissue images were then acquired and examined, revealing deep penetration and high contrast with the new pyranyl RGD-conjugates up to 350 μm in tumor tissue.

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Section: Introductionmentioning

confidence: 99%

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

et al. 2015

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“…On the other hand, Zhang et al [36,37] have developed a number of covalent strategies for fabrication of AIE dyes containeing amphiphilic FONs through reversible addition-fragmentation chain-transfer (RAFT) polymerization and cross-linking. [38][39][40][41][42][43][44][45][46] However, most of these strategies still have some shortcoming. For example, most of commercially available amphiphilic compounds are expensive, and the obtained nanoprobes are often not stable when the concentration is lower than the critical micelle concentration (CMC).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Amphiphilic Hyperbranched AIE‐active Fluorescent Organic Nanoparticles and Their Application in Biological Application

Wang

Xü

et al. 2015

Macromolecular Bioscience

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Aggregation-induced emission (AIE) dyes have recently attracted much attention for biomedical applications for their remarkable AIE properties. However, the hydrophobic nature of AIE dyes made them difficult to be dispersed in physiological solution and problematic for biomedical application directly. Great efforts have been made to overcome this problem, and different strategies for preparation of water dispersible AIE based nanoprobes had been explored previously. However, a facile and effective strategy is still highly desirable and of great importance for the biomedical applications of AIE dye based on nanoprobes. In this work, the fabrication of amphiphilic hyperbranched fluorescent organic nanoparticles with a core-shell structure based on an AIE dye [tetraphenylethene acrylate (TPE-O-E)] and a hyperbranched polyamino compound [polyethylene imine (PEI)] through Michael addition reaction is described for the first time. The AIE dye as well as the final product PEI-TPE-O-E was characterized in detail by a number of techniques. To test their biomedical application potential, the cell viability as well as cell imaging properties of the PEI-TPE-O-E was also examined. The results showed that the PEI-TPE-O-E organic nanoparticles presented high water dispersiblity, ultrabright fluroerescence, low cytotoxicity and excellent biocompatibility, making them promising for biological imaging and gene delivery applications.

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“…Possessing good AIE and 2PA properties, high brightness in the red region, and the largest two-photon action cross-section (sF f ) [41] of 333.9 GM, we chose DPP-TPE-3 as the luminogen for bioimaging. Also, we used the organically modified silica (ORMOSIL) nano-particles to encapsulate DPP-TPE-3 to endow it with good water solubility and the preparation method referred to the published literature [42,43].…”

Section: Fabrication Of Dpp-tpe-3-ormosil Nanoparticlesmentioning

confidence: 99%

Tetraphenylethene end-capped diketopyrrolopyrrole fluorogens with AIE and large two-photon absorption cross-sections features and application in bioimaging

Jiang

Hang

et al. 2016

Dyes and Pigments

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Lipid‐PEG‐Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two‐Photon Fluorescence Imaging

Cited by 142 publications

References 48 publications

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

Synthesis of Amphiphilic Hyperbranched AIE‐active Fluorescent Organic Nanoparticles and Their Application in Biological Application

Tetraphenylethene end-capped diketopyrrolopyrrole fluorogens with AIE and large two-photon absorption cross-sections features and application in bioimaging

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