Lipid Parameters – Significance in Patients with Endogenous Depression

Kale, Aditya

doi:10.7860/jcdr/2014/4059.3911

Cited by 16 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study examined associations with the outcomes primarily using a dichotomous LDL definition (LDL <1.5 mmol/L), but also explored relationships using continuous measures. This dichotomous threshold for low LDL was chosen because of the high frequency of LDL <2.0 mmol/L in statin-treated CAD patients33 and data suggesting that cognition/brain functioning is theoretically most adversely affected when LDL serum concentrations are <1.5 mmol/L 1,34…”

Section: Methodsmentioning

confidence: 99%

Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Rej¹,

Saleem

Herrmann

et al. 2016

NDT

View full text Add to dashboard Cite

AimStatins have been associated with decreased cognition due to the effects of low concentrations of low-density lipoprotein (LDL) on brain function. This has remained controversial and is particularly relevant to patients with coronary artery disease (CAD), who have an increased risk of cognitive decline and are frequently prescribed statins. This study hypothesized that low concentration of LDL is associated with poor cognition in CAD patients using statins. It also explored the association between high-dose versus low-dose statins on cognition in this population.Patients and methodsBaseline cross-sectional data from a longitudinal study of 120 statin-using CAD patients were examined (mean statin duration 25±43 months). The main outcomes were measures of global cognition and cognitive domains, with poor cognition defined as cognitive performance ≤1 standard deviation below the population age and education adjusted means. A battery of cognitive tests was used to assess verbal memory, executive function, speed of processing, visuospatial memory, and global cognition. Adjusting for age, sex, education, and other covariates, multivariable logistic regression analyses assessed associations between low LDL levels (<1.5 mmol/L), statin use, and poor cognition.ResultsLDL levels were not associated with global cognition or individual cognitive domains. High-dose statin use was associated with higher visuospatial memory (odds ratio, OR [95% confidence interval, CI] =0.12 [0.02–0.66], P=0.01) and executive functioning (OR =0.25 [0.06–0.99], P=0.05). This effect was independent of covariates such as LDL levels.ConclusionLow LDL levels do not appear to be associated with poor cognition in CAD patients using statins. Whether high-dose statin use may have positive effects on cognition in CAD patients could be investigated in future studies.

show abstract

Section: Methodsmentioning

confidence: 99%

Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Rej¹,

Saleem

Herrmann

et al. 2016

NDT

View full text Add to dashboard Cite

show abstract

“…total cholesterol (TC), triglycerides (TG), high-density (HDL), low-density (LDL) and very-low-density (VLDL) lipoproteins in the context of depression show that all those parameters were lower in the patient group, compared to the control group [72]. Dimopoulos found a correlation between low TC and depression in the elderly patients [73].…”

Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

show abstract

“…Em relação à dislipidemia, percentuais elevados foram encontrados no presente estudo (73,1%), especialmente níveis baixos de HDL. Estudos têm demonstrado relação inversa entre níveis de colesterol e depressão, e foi descoberta correlação negativa significativa entre o perfil lipídico e a depressão, indo contra os resultados obtidos nessa amostra 36 . Além disso, descobriu-se que quanto mais baixos os níveis séricos de Colesterol total, LDL e VLDL maior eram os valores de BDI 36 .…”

Section: Discussionunclassified

Fatores de risco para o desenvolvimento de doença cardiovascular em pacientes com depressão em um hospital do sul do Brasil

Schuh

Rockett

Sauer

et al. 2020

CBR

View full text Add to dashboard Cite

show abstract

Lipid Parameters – Significance in Patients with Endogenous Depression

Abstract: Background: People are aware of the consequences of high serum lipid levels, specifically, total cholesterol. Awareness about harmful effects of very low levels of serum lipids is still lacking. Very low levels of serum lipids lead to psychological consequences.

Cited by 16 publications

References 10 publications

Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Application of fatty acid and lipid measurements in neuropsychiatry

Fatores de risco para o desenvolvimento de doença cardiovascular em pacientes com depressão em um hospital do sul do Brasil

Contact Info

Product

Resources

About