Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

Bellanti, Francesco; Villani, Rosanna; Facciorusso, Antonio; Vendemiale, Gianluigi; Serviddio, Gaetano

doi:10.1016/j.freeradbiomed.2017.01.023

Cited by 108 publications

(88 citation statements)

References 226 publications

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“…HNE is a special apoptotic inducer because of its abilities to oxidise mitochondrial DNA, protein and to form protein adducts [20]. A significant increase in mitochondrial HNE-protein adducts during NASH development has been also reported [68][69][70][71][72]. In addition, oxidation of biomolecules by mitochondrial ROS initiates a vicious cycle of exacerbated mitochondrial dysfunction and cell death [79].…”

Section: Hne and Liver Injury In Nafldmentioning

confidence: 98%

“…The mechanisms by which steatosis progresses to NASH are still not fully understood; however, growing evidence has suggested that oxidative stress is involved in this process [69][70][71][72][73]. Oxidative stress is generated through oxidation of free fatty acids, cytochrome P450, iron overload, and necro-inflammatory cytokines such as TNF-a [74][75][76].…”

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

“…Lipid peroxide HNE in steatotic liver may synergistically activate the JNK/c-Jun signalling pathway that augmentes liver injury and apoptosis [93]. HNE-induced JNK activation is inhibited by pretreatment of the cells with a thiol antioxidant, N-acetylcysteine [41,72,94]. Tsuruta et al [95] showed JNK-induced Bax translocation to mitochondria, cytochrome c release and apoptosis.…”

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

“…HNE is one of the major end-products of lipid peroxidation generated during the transition from simple steatosis to steatohepatitis [72]. Therefore HNE generated by NAFLD is not only a passive biomarker but rather an active mediator of hepatocellular injury [31,93].…”

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

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4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

Bekyarova

Tzaneva

Bratoeva

et al. 2019

Biotechnology & Biotechnological Equipment

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4-Hydroxynonenal (HNE), a major end-product of free-radical activated peroxidation of polyunsaturated fatty acids, has attracted great scientific interest. HNE is more stable than free radicals and can diffuse within the cell or leave it and react with targets far from the initial site. These reactive aldehyde species are considerably reactive, producing multiple intra-and inter-molecular covalent adducts with biomolecules such as proteins, DNA and phospholipids. HNE is the most intensively studied aldehyde in relation to its physiological and protective function as a signalling molecule that stimulates gene expression and cell survival, as well as for its pathophysiological role as a toxic messenger that can propagate and amplify oxidative injury and promote mitochondrial dysfunction and cell death. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world associated with oxidative stress, mitochondrial dysfunction and hepatocellular apoptosis. In this review we focus our attention on the molecular mechanism of the signalling and regulatory action of HNE. The role of HNE as a potent mediator for progression of liver injury in NAFLD is also discussed.

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Section: Hne and Liver Injury In Nafldmentioning

confidence: 98%

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

Section: Hne and Liver Injury In Nafldmentioning

confidence: 99%

See 2 more Smart Citations

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

Bekyarova

Tzaneva

Bratoeva

et al. 2019

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

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“…The pathogenesis of non‐alcoholic fatty liver disease (NAFLD) is yet to be explored completely (Bellanti, Villani, Facciorusso, Vendemiale, & Serviddio, ; Doulberis, Kotronis, Gialamprinou, Kountouras, & Katsinelos, ; Fujiwara, Friedman, Goossens, & Hoshida, ). NAFLD develops across people of all age groups and ethnicities (Kalia & Gaglio, ).…”

Section: Introductionmentioning

confidence: 99%

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

2018

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The current research was focused at investigating the different doses of germinated mung bean (GMB) (Vigna Radiata [Fabaceae]) on progression of non‐alcoholic steatohepatitis (NASH) from steatosis. Beneficial effects of GBM against NASH from steatosis‐induced liver injury were apparent from decreased serum transaminase activities, lipid peroxidation and nitrite/nitrate contents, and recoupment of glutathione. Enzymatic antioxidants were inclined toward normal in high dose GMB supplemented rats. On the other hand low dose of GMB prevented further alteration when compared with steatosis. Gene expression analysis shows that supplementation of GMB restores the antioxidant enzyme gene expressions. GMB effect was confirmed through histopathological observation, which is correlated along with lipid reduction and various inflammatory cytokine restoration. Further GMB could abrogate alleviated mitochondrial ROS generation. In summary, GMB has a huge potential to decrease the consequence of oxidative stress, which could be one of the contributing mechanism to its protective effect in attenuating the progression of NASH. Practical applications Mung bean is widely consumed world‐wide by all the population. Germinated mung bean prevents development of steatohepatitis from steatosis. Higher consummation may be recommended for their betterment of liver health.

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Non‐alcoholic Fatty Liver Disease

Rotman

Kapuria

2020

The Liver

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Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

Cited by 108 publications

References 226 publications

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

Protective role of germinated mung bean against progression of non-alcoholic steatohepatitis in rats: A dietary therapy to improve fatty liver health

Non‐alcoholic Fatty Liver Disease

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