Lipid oxidation in pathophysiology of atherosclerosis: Current understanding and therapeutic strategies

Salekeen, Rahagir; Haider, Abu Nasim; Akhter, Fouzia; Billah, Morsaline; Islam, Md. Emdadul; Islam, Kazi Mohammed Didarul

doi:10.1016/j.ijcrp.2022.200143

Cited by 15 publications

(11 citation statements)

References 86 publications

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“…Hyperglycemia increases the formation of oxidized and glycated LDL [13]. A recent study on the role of lipid oxidation in atherosclerosis development provides a graph demonstrating the development of a glucose response after eating, along with increased oxidative stress and altered endothelial function [16].…”

Section: Dyslipidemia and Hyperglycemiamentioning

confidence: 99%

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Diabetic Neuropathy of the Retina and Inflammation: Perspectives

Bikbova

Oshitari

Бикбов

2023

IJMS

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A clear connection exists between diabetes and atherosclerotic cardiovascular disease. Consequently, therapeutic approaches that target both diseases are needed. Clinical trials are currently underway to explore the roles of obesity, adipose tissue, gut microbiota, and pancreatic beta cell function in diabetes. Inflammation plays a key role in diabetes pathophysiology and associated metabolic disorders; thus, interest has increased in targeting inflammation to prevent and control diabetes. Diabetic retinopathy is known as a neurodegenerative and vascular disease that occurs after some years of poorly controlled diabetes. However, increasing evidence points to inflammation as a key figure in diabetes-associated retinal complications. Interconnected molecular pathways, such as oxidative stress, and the formation of advanced glycation end-products, are known to contribute to the inflammatory response. This review describes the possible mechanisms of the metabolic changes in diabetes that involve inflammatory pathways.

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Section: Dyslipidemia and Hyperglycemiamentioning

confidence: 99%

“…Oxidized LDL products provoke pro-inflammatory mechanisms involving immune cell mobilization and local cytokine storms; nuclear factor-kappa B (NF-κB) and C-reactive protein are used as inflammatory biomarkers to assess the risk of ischemic damage [16].…”

Section: Dyslipidemia and Hyperglycemiamentioning

confidence: 99%

Diabetic Neuropathy of the Retina and Inflammation: Perspectives

Bikbova

Oshitari

Бикбов

2023

IJMS

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“…As the disease progresses, the atheroma grows and steadily narrows the lumen of the blood vessel. Simultaneously, vascular Smooth Muscle cells (vSMC), the main cells forming the subintima layer ( tunica media ), migrate to the intima layer, changing towards a more proliferative phenotype, in order to form a fibrous collagen cap on the plaque, providing stability and preventing interaction between the necrotic core within the plaque, and the external lumen ( Singh et al, 2002 ; Salekeen et al, 2022 ). Advanced plaque formation is mainly attributed to an inefficient clearance of late apoptotic bodies (i.e., neutrophils) by macrophages, a non-phlogistic process known as efferocytosis .…”

Section: Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Posing the rationale for synthetic lipoxin mimetics as an adjuvant treatment to gold standard atherosclerosis therapies

Millar

Gaetano²

2023

Front. Pharmacol.

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Atherosclerosis is a progressive, multifactorial inflammatory, and dyslipidaemic disease, responsible for the majority of cardiovascular diseases globally. The chronic inflammation is the main driver of the initiation and progression of such disease, as a result of an imbalanced lipid metabolism and an ineffective immune response to attenuate the inflammatory component. The importance of inflammation resolution is being increasingly recognised in atherosclerosis and cardiovascular disease. It has a complex mechanism consisting of multiple stages, including restoring an effective removal of apoptotic bodies (efferocytosis) and their degradation (effero-metabolism), a macrophage phenotype switching towards resolving phenotypes, and the promotion of tissue healing and regeneration. The low-grade inflammation associated with atherosclerosis development is a driving force in disease exacerbation, and hence inflammation resolution is a key area of research. In this review, we explore the complex disease pathogenesis and its many contributing factors to gain a greater understanding of the disease and identify the current and potential therapeutic targets. First-line treatments and their efficacy will also be discussed in detail, to highlight the emerging field of resolution pharmacology. Despite the great efforts made by current gold-standard treatments, such as lipid-lowering and glucose-lowering drugs, they remain ineffective at tackling residual inflammatory risk and residual cholesterol risk. Resolution pharmacology represents a new era of atherosclerosis therapy, as endogenous ligands associated with inflammation resolution are exploited for their pharmacological benefits in a more potent and longer-acting manner. Novel FPR2-agonists, such as synthetic lipoxin analogues, provide an exciting new approach to enhance the pro-resolving response of the immune system and subsequently end the pro-inflammatory response to allow for an anti-inflammatory and pro-resolving environment for tissue healing, regeneration, and return to homeostasis.

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“…The causes of endothelial dysfunction as well as CVD are multifactorial and include an unhealthy dietary habit, alcohol consumption, and a lack of exercise, and these causes are interrelated ( Rafieian-Kopaei, 2014 ). Protein carbonylation, lipid peroxidation, ethanol metabolism, and deterioration of antioxidant capacity are commonly induced by such lifestyle habits, and they directly contribute to induce oxidative conditions in the vasculature, leading to endothelial dysfunction ( Lesgards, 2002 , Obad, 2018 , Salekeen, 2022 , Ou, 2017 ). Cigarette smoking also causes oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

RNA sequencing analysis of early-stage atherosclerosis in vascular-on-a-chip and its application for comparing combustible cigarettes with heated tobacco products

Ohashi,

Hayashida,

Nozawa

et al. 2024

Current Research in Toxicology

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Lipid oxidation in pathophysiology of atherosclerosis: Current understanding and therapeutic strategies

Cited by 15 publications

References 86 publications

Diabetic Neuropathy of the Retina and Inflammation: Perspectives

Diabetic Neuropathy of the Retina and Inflammation: Perspectives

Posing the rationale for synthetic lipoxin mimetics as an adjuvant treatment to gold standard atherosclerosis therapies

RNA sequencing analysis of early-stage atherosclerosis in vascular-on-a-chip and its application for comparing combustible cigarettes with heated tobacco products

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