Lipid oxidation: Biologic effects and antioxidants—A review

Abstract

The detection and measurement of lipid oxidation in biological systems and some biologic effects of this oxidation are reviewed. The role of lipid oxidation in the process of photocarcinogenesis and the protective effect of antioxidants against this process also are discussed. The mechanism of such protection is unknown and studies directed at elucidating the mechanism of antioxidant effect in photocarcinogenesis and in some other pathological conditons believed to involve lipid oxidation are needed. In addition to this, epoxidation of lipids observed in monolayer studies requires further investigation, particularly in the presence of some other unsaturated molecules. The possible significance of such a study--particularly in the presence of polycyclic aromatic hydrocarbon carcinogens, where formation of epoxides is generally accepted as active intermediates--is also discussed. In addition, present knowledge on the role of lipid peroxides in the destruction of proteins and biomembranes, in chemically induced toxicity and in generation of singlet oxygen is presented.

Effects of processing techniques on oxidative stability of <em>Prunus pedunculatus</em> seed oil

“…This could be due to the presence of the high γ-tocopherol (551.1-644.88 mg/kg) or the low content of linolenic acid (0.12%-0.23%) in the P. Pedunculatus; meanwhile, TBA were secondary products of lipid oxidation, and require more time to be formed, so that the other reason could be that more TBA haven't been formed in this storage period. These low 2-TBA levels were in agreement with those previously reported in the literature (Abou-Gharbia et al, 1997;Logani and Davies, 1980).…”

Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

“…Epidemiological evidence has long associated high fat diets with increased risk for neoplastic development, including cutaneous malignancy 73,74 . It has since become apparent that increased cancer risk from high fat diets is due in part to higher levels of oxidized lipid species 74,75 .…”

“…It has since become apparent that increased cancer risk from high fat diets is due in part to higher levels of oxidized lipid species 74,75 . A potential role for PPARγ in cutaneous carcinogenesis is indicated by a recent study demonstrating that mice deficient in either epidermal PPARγ or its heterodimer partner, RXR, exhibit increased rates of cutaneous neoplasia following a chemical carcinogenesis protocol 76 .…”

Methods for Evaluation of the Oxidative Stability of Lipid-Containing Foods.

“…Lipids containing methyleneinterrupted dienes or polyenes show a shift in their double bond position during oxidation due to isomerization and conjugation formation (Logani & Davies, 1980). The resulting conjugated dienes exhibit intense absorption at 234 nm; similarly, conjugated trienes absorb at 268 nm.…”