Lipid Nanostructures in Food Applications

Hoque, Monjurul; Agarwal, Saumya; Gupta, Sweta; Garg, Sourav; Syed, Irshaan; Rupesh, Akinapally; Mohapatra, Nupur; Bose, Subhadeep; Sarkar, Preetam

doi:10.1016/b978-0-08-100596-5.23047-3

Cited by 6 publications

(7 citation statements)

References 119 publications

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“…Phytosomes or herbosomes are vesicular systems obtained through the interaction between hydrophilic parts of the phospholipids and the phyto-active components, resulting in the formation of hydrogen bonds between them [ 19 , 29 , 68 ]. Phytosomes are considered a type of liposomal formulation, also called phyto-phospholipid complexes.…”

Section: Types Of Vesicular Nanosystemsmentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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The need to develop wound healing preparations is a pressing challenge given the limitations of the current treatment and the rising prevalence of impaired healing wounds. Although herbal extracts have been used for many years to treat skin disorders, due to their wound healing, anti-inflammatory, antimicrobial, and antioxidant effects, their efficacy can be questionable because of their poor bioavailability and stability issues. Nanotechnology offers an opportunity to revolutionize wound healing therapies by including herbal compounds in nanosystems. Particularly, vesicular nanosystems exhibit beneficial properties, such as biocompatibility, targeted and sustained delivery capacity, and increased phytocompounds’ bioavailability and protection, conferring them a great potential for future applications in wound care. This review summarizes the beneficial effects of phytocompounds in wound healing and emphasizes the advantages of their entrapment in vesicular nanosystems. Different types of lipid nanocarriers are presented (liposomes, niosomes, transferosomes, ethosomes, cubosomes, and their derivates’ systems), highlighting their applications as carriers for phytocompounds in wound care, with the presentation of the state-of-art in this field. The methods of preparation, characterization, and evaluation are also described, underlining the properties that ensure good in vitro and in vivo performance. Finally, future directions of topical systems in which vesicle-bearing herbal extracts or phytocompounds can be incorporated are pointed out, as their development is emerging as a promising strategy.

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Section: Types Of Vesicular Nanosystemsmentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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“…The active materials are incorporated in the aqueous core of the vesicles or in the lipid bilayer membrane [55,97,98] Preparation…”

Section: Phytosomes and Other Lipid-based Nanocarriers: Similarities And Differencesmentioning

confidence: 99%

“…In case of liposomes and transferosomes preparation, phospholipid is mixed first with lipids to make the liposomal vesicle. Then, the phytochemical is incorporated in the liposome later [ 97 , 98 ]. ( B ) Represent the composition of phospholipid moiety.…”

Section: Phytosomesmentioning

confidence: 99%

“…Structurally, bioactive molecules are part of the phytosomes membrane [ 97 ], whereas the hydrophilic molecules are engulfed in the aqueous core of liposomes and transferosomes or entrapped in the lipid layer membrane if they have a lipophilic nature [ 98 ]. The structure of phytosomes is based on the H-bond interaction between the phytoconstituents and the polar moiety of phospholipid molecules [ 104 ], whereas no chemical interaction occurs in liposomes and transferosomes because the encapsulated materials are entrapped naturally in the lipid bilayer membrane or in the aqueous core [ 105 ].…”

Section: Phytosomesmentioning

confidence: 99%

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Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals

et al. 2021

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The emergence of phytosome nanotechnology has a potential impact in the field of drug delivery and could revolutionize the current state of topical bioactive phytochemicals delivery. The main challenge facing the translation of the therapeutic activity of phytochemicals to a clinical setting is the extremely low absorption rate and poor penetration across biological barriers (i.e., the skin). Phytosomes as lipid-based nanocarriers play a crucial function in the enhancement of pharmacokinetic and pharmacodynamic properties of herbal-originated polyphenolic compounds, and make this nanotechnology a promising tool for the development of new topical formulations. The implementation of this nanosized delivery system could enhance the penetration of phytochemicals across biological barriers due to their unique physiochemical characteristics, improving their bioavailability. In this review, we provide an outlook on the current knowledge of the biological barriers of phytoconstituents topical applications. The great potential of the emerging nanotechnology in the delivery of bioactive phytochemicals is reviewed, with particular focus on phytosomes as an innovative lipid-based nanocarrier. Additionally, we compared phytosomes with liposomes as the gold standard of lipid-based nanocarriers for the topical delivery of phytochemicals. Finally, the advantages of phytosomes in topical applications are discussed.

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“…To overcome the aforementioned limitations of neat biopolymer-based films, several modification techniques are being applied, such as: the use of cross-linkers like glutaraldehyde, citric acid, calcium chloride, formaldehyde [33,36,37]; the addition of additives like plasticizers; functional components like essential oils; and antimicrobial compounds such as nisin and lysozymes [35,38,39]. Other techniques include hydrophobic modification with structured oil nanoparticles [29,[40][41][42], incorporating organic and inorganic fillers [30], coating biopolymers with synthetic polymers, or a combination of two or more biopolymers having potential packaging properties [43][44][45][46]. The application of novel technologies like high-pressure processing, cold plasma, ultrasonication, high-pressure homogenization, irradiation, and microwaves [47] have also been examined.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cold Plasma Treatment on the Packaging Properties of Biopolymer-Based Films: A Review

et al. 2022

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Biopolymers, like polysaccharides and proteins, are sustainable and green materials with excellent film-forming potential. Bio-based films have gained a lot of attention and are believed to be an alternative to plastics in next-generation food packaging. Compared to conventional plastics, biopolymers inherently have certain limitations like hydrophilicity, poor thermo-mechanical, and barrier properties. Therefore, the modification of biopolymers or their films provide an opportunity to develop packaging materials with desired characteristics. Among different modification approaches, the application of cold plasma has been a very efficient technology to enhance the functionality and interfacial characteristics of biopolymers. Cold plasma is biocompatible, shows uniformity in treatment, and is suitable for heat-sensitive components. This review provides information on different plasma generating equipment used for the modification of films and critically analyses the impact of cold plasma on packaging properties of films prepared from protein, polysaccharides, and their combinations. Most studies to date have shown that plasma treatment effectively enhances surface characteristics, mechanical, and thermal properties, while its impact on the improvement of barrier properties is limited. Plasma treatment increases surface roughness that enables surface adhesion, ink printability, and reduces the contact angle. Plasma-treated films loaded with antimicrobial compounds demonstrate strong antimicrobial efficacy, mainly due to the increase in their diffusion rate and the non-thermal nature of cold plasma that protects the functionality of bioactive compounds. This review also elaborates on the existing challenges and future needs. Overall, it can be concluded that the application of cold plasma is an effective strategy to modify the inherent limitations of biopolymer-based packaging materials for food packaging applications.

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Lipid Nanostructures in Food Applications

Cited by 6 publications

References 119 publications

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals

Effect of Cold Plasma Treatment on the Packaging Properties of Biopolymer-Based Films: A Review

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