Lipid Nanoparticulate Drug Delivery and Nanomedicine

Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery

“…Research efforts are being made in using a targeted mode of delivery to target the site of infection directly, such as inhalation aerosols for pulmonary infections and by employing nanomedicine. [7][8][9][10][11][12][13] Targeted pulmonary delivery of antimicrobials (ie, antibacterials and antifungals) by inhalation aerosols is the subject of much recent interest in research and development, including several clinical trials. [8][9][10][11] Pulmonary liposomal aerosol delivery of antimicrobials can effectively fight infections, [14][15][16][17] and these liposomal delivery systems can be rendered into inhalable dry powder aerosols.…”

“…22 The major component of lung surfactant is the phospholipid dipalmitoylphosphatidylcholine (DPPC), which is an essential component in normal lung surfactant, can alleviate compromised lung compliance 23 and is used in nanopharmaceutical applications. 10 Phospholipids are biocompatible, biodegradable excipients that can improve inhaled particle migration to the lung periphery. [24][25][26][27] High-dose delivery, higher chemical stability relative to the liquid state, and the potential to tailor particle properties in the solid state are all advantages of dry powder inhalers (DPIs).…”

Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols

“…29 In addition, there are successful nanopharmaceutical products containing PEGylated phospholipid for intravenous administration, as it is an FDA-approved excipient. 14,20,21,32 Sterically stabilized nanomicelles comprised of PEGylated phospholipids with encapsulated drug for the treatment of acute lung injury by the intravenous route have been reported. 34,35 The spray-drying method is an advanced high-throughput pharmaceutical manufacturing process that is used to efficiently produce and tailor respirable particles in the solid state.…”

“…1,14,28 The use of poly(ethylene glycol) (PEG)-based liposomal formulations has been motivated by the advantage of having biocompatible self-assembled drug-delivery systems that can evade the recognition and uptake by cells in the immune system while prolonging the residence time of the liposomes and providing sustained drug release. 14,[29][30][31][32] In addition, PEG has been recently demonstrated to have inherent mucus-penetrating properties. 33 Unlike other types of inhaled particles, the fate of phospholipid-based particles can have a similar fate to native lipids.…”

“…34,35 The spray-drying method is an advanced high-throughput pharmaceutical manufacturing process that is used to efficiently produce and tailor respirable particles in the solid state. 2,8,14,36 Spray-drying has been used in the microencapsulation of bioactive molecules, as well as in the preparation of drug-delivery systems composed of a large variety of biodegradable polymers and excipients. [37][38][39] It has also been used as a scalable method in the bulk preparation of drug-lipid mixtures.…”