Lipid nanoparticles for siRNA delivery in cancer treatment

Moukhtari, Souhaila H. El; Garbayo, Elisa; Amundarain, Ane; Pascual-Gil, Simón; Carrasco‐Leon, Arantxa; Prósper, Felipe; Agirre, Xabier; Blanco-Prieto, María J.

doi:10.1016/j.jconrel.2023.07.054

Cited by 28 publications

(11 citation statements)

References 149 publications

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“…The aqueous solution core is surrounded by a hydrophobic membrane, which hampers the exudation of encapsulated hydrophilic solutes in the core . Encapsulation technologies can be divided into two types: passive encapsulation technologies, which rely on the random capture of molecules during liposome formation, and active encapsulation technologies, which rely on the presence of transmembrane ion gradients or charged lipids . Liposomes could be developed by disrupting biological membranes .…”

Section: Biomaterials Help To Anti-sars-cov-2 Strategiesmentioning

confidence: 99%

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Hu,

Liu,

Zhang

et al. 2024

ACS Omega

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The coronavirus disease-19 (COVID-19) pandemic has had a significant impact on human life worldwide since 2019. Specific vaccines and antiviral agents are the most effective means of preventing and treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Additionally, antiviral protective equipment and early diagnosis also contribute to controlling the spread of COVID-19. The utilization of biomaterials in medicine and pharmaceuticals is crucial to ensure the positive impact of vaccines, antiviral agents, and protective equipment. In this review, we discuss the application of various types of biomaterials, including polymers, lipid nanoparticles, inorganic biomaterials, protein-or peptide-associated biomaterials, selfassembled biomaterials, and other biomaterials, for the vaccine, treatment, and prevention of COVID-19. Finally, we provide a perspective on future opportunities and challenges for developing biomaterials to combat other viral outbreaks and diseases.

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Section: Biomaterials Help To Anti-sars-cov-2 Strategiesmentioning

confidence: 99%

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Hu,

Liu,

Zhang

et al. 2024

ACS Omega

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“… 103 , 104 There are also R8 peptide‐PEGylated targeted liposomes for the treatment of gliomas, and data suggest good sustained release properties, improved stability, and increased liposomal ability to cross the blood–BBB. 105 , 106 Liposomes as a type of drug delivery system have significant advantages in antitumor drug delivery and are used in clinical practice to improve the efficacy of antitumor drugs and drug resistance.…”

Section: Overview Of Npsmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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“…RNA interference (RNAi), also known as gene silencing, refers to the highly conserved phenomenon induced by double-stranded RNA (dsRNA) in the process of evolution and the efficient and specific degradation of homologous mRNA . Application of RNAi to specifically eliminate or turn off the expression of specific genes has been widely applied as a gene regulation technology for a variety of pathological conditions including autoimmune disorders, genetic disorders, cancer, or viral infections. , However, the lack of a suitable delivery system of siRNA remains a pivotal limitation for the administration of RNAi technology in disease treatment . Viruses have shown outstanding delivery efficiency toward siRNA, but the immunogenicity and mutagenic toxicity seriously prevent their applications in vivo. , Although nonviral delivery materials such as inorganic nanoparticles and polymeric and cationic liposomes can transfer siRNA, they still face issues of safety and efficiency. − Furthermore, most nonviral siRNA carriers were composed of cationic materials that present a positive surface charge.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Hydrogel Nanoparticles with Lysosomal Escape Properties for the Delivery of siRNA for the Gene Therapy of Colorectal Carcinoma

Yu,

Zheng,

Xie

et al. 2024

ACS Appl. Nano Mater.

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Although the significance of the curative effect has been recognized, ideal nanocarriers with the properties of lysosomal escape and biocompatibility are still lacking for the development of siRNA-based cancer gene therapy. In this work, a lysosomal escaped and redox-responsive polyacrylamide nanohydrogel (cRGD-9R-PA ss ) was constructed for STAT3 siRNA delivery. The functional groups, including tumor-targeting peptide cRGD, cell-penetrating and lysosome-escaping peptide 9R, and a redoxresponsive disulfide bond, were introduced to the polyacrylamide nanohydrogel to attain enhanced transfection efficiency and biocompatibility. The synthesized cRGD-9R-PA ss (siRNA) was dispersed as core−shell nanoparticles in water with an average size of 48 nm. cRGD-9R-PA ss (siRNA) could prevent lysosomal phagocytosis and responsive release STAT3 siRNA into C26 tumor cells, thus promoting STAT3 gene silencing and inhibiting the proliferation of cancer cells in vitro and in vivo. Our results demonstrate that cRGD-9R-PA ss hydrogel nanospheres constitute a potential candidate vector for siRNA-based colon cancer gene therapy.

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Lipid nanoparticles for siRNA delivery in cancer treatment

Cited by 28 publications

References 149 publications

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Biocompatible Hydrogel Nanoparticles with Lysosomal Escape Properties for the Delivery of siRNA for the Gene Therapy of Colorectal Carcinoma

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