Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery

Ganesan, P.; Damodharan, N

doi:10.1016/j.scp.2017.07.002

Cited by 304 publications

(214 citation statements)

References 170 publications

Supporting

Mentioning

210

Contrasting

Unclassified

Order By: Relevance

“…With respect to the majority of other kinds of nanovectors, the preparation of SLN and NLCs does not require the use of toxic organic solvents. The two principal fabrication methods are the high‐pressure homogenization (HPH) and the microemulsion technique . HPH involves breaking up primary large lipidic aggregates into sub‐micron particles by using a high‐pressure homogenizer.…”

Section: Nanovectors For Antioxidant Targeting and Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

Many central nervous system (CNS) diseases are still incurable and only symptomatic treatments are available. Oxidative stress is suggested to be a common hallmark, being able to cause and exacerbate the neuronal cell dysfunctions at the basis of these pathologies, such as mitochondrial impairments, accumulation of misfolded proteins, cell membrane damages, and apoptosis induction. Several antioxidant compounds are tested as potential countermeasures for CNS disorders, but their efficacy is often hindered by the loss of antioxidant properties due to enzymatic degradation, low bioavailability, poor water solubility, and insufficient blood–brain barrier crossing efficiency. To overcome the limitations of antioxidant molecules, exploitation of nanostructures, either for their delivery or with inherent antioxidant properties, is proposed. In this review, after a brief discussion concerning the role of the blood–brain barrier in the CNS and the involvement of oxidative stress in some neurodegenerative diseases, the most interesting research concerning the use of nano‐antioxidants is introduced and discussed, focusing on the synthesis procedures, functionalization strategies, in vitro and in vivo tests, and on recent clinical trials.

show abstract

Section: Nanovectors For Antioxidant Targeting and Deliverymentioning

confidence: 99%

“…In the microemulsion method, the lipids are melted and mixed under stirring with a small amount of a surfactant solution at the same temperature. Thereafter, a sufficiently high volume of water at 2–3 °C is added to solidify the initial lipid droplets …”

Section: Nanovectors For Antioxidant Targeting and Deliverymentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Several types of solid lipids including fatty acids, triglycerides, partial glycerides, waxes and steroids can be used as the main ingredients of SLNs. The most frequently used surfactants are poloxamers, polysorbates, lecithins, polyvinyl alcohol and bile salts for providing the stabilization of nanodispersion [24][25] .…”

Section: Introductionmentioning

confidence: 99%

Development and Statistical Optimization of Solid Lipid Nanoparticle Formulations of Fluticasone Propionate

Amasya

Sengel-Türk

Badıllı

et al. 2020

tjps

View full text Add to dashboard Cite

INTRODUCTION: The aim of this study was to develop Fluticasone propionate (FP)-loaded solid lipid nanoparticle (SLN) formulations using the factorial design approach. METHODS: Tristearin percentages (X1) (1%, 2% and 4%) and homogenization cycles (X2) (2, 4, 8 cycles) were selected as independent variables in the factorial design. SLN formulations were optimized by multiple regression analysis (MLR) to evaluate the influence of the selected process and formulation independent variables on SLNs characteristics namely as encapsulation efficiency (Q1) and particle size (Q2). Polydispersity index and surface charge of the SLNs were also evaluated in this research. Besides, transmission electron microscopy, Differential scanning calorimetry and in vitro drug relase studies were carried out on the optimum SLN formulation. RESULTS: MLR analysis indicated that as homogenization cycle (X2) increased in the production process, the mean particle size was decreased. DISCUSSION AND CONCLUSION: This research displayed that FP-encapsulated SLNs with desired characteristics can be produced by varied the production and content variables of the formulations. Özet GİRİŞ ve AMAÇ: Bu çalışmanın amacı, faktöriyel tasarım yaklaşımını kullanarak Flutikazon propiyonat (FP) yüklü katı lipid nanopartikül formülasyonları geliştirmektir. YÖNTEM ve GEREÇLER: Bu amaçla faktöriyel tasarımda Tristearin yüzdeleri (X1) (% 1, % 2 ve % 4) ve homojenizasyon döngüleri (X2) (2, 4 ve 8 döngü) bağımsız değişkenler olarak seçilmiştir. Seçilen işlem ve formülasyona ait bağımsız değişkenlerin, katı lipid nanopartikül formülasyonların enkapsülasyon etkinliği (Q1) ve partikül boyututları (Q2) üzerindeki etkisini değerlendirmek için çoklu regresyon analizi (MLR) ile optimize edilmiştir. Çalışmada ayrıca nanopartiküllere ait polidispersite indeksi ve yüzey yükleri de değerlendirilmiştir. Bunun yanı sıra optimum katı lipid nanopartikül formülasyonu üzerinde geçirimli elektron mikroskopu, difransiyel taramalı kalorimetre analizi ve in vitro etkin madde salım çalışmaları da yapılmıştır. BULGULAR: MLR analizi, üretim sürecinde homojenizasyon döngüsü (X2) arttıkça, ortalama partikül boyutunun azaldığını göstermiştir. TARTIŞMA ve SONUÇ: Bu araştırma, istenen özelliklere sahip FP yüklenmiş katı lipid nanopartiküllerin, formülasyonların üretim ve içerik değişkenlerini değiştirerek üretilebileceğini göstermektedir. Anahtar Kelimeler: Deneysel tasarım, Flutikazon propionat, Nanopartiküller u n c o r r e c t e d p r o o f

show abstract

“…Besides their relatively easy manufacturing, SLNs may positively affect drug uptake through various ways, such as enhancing the extent of solubility, hindering drug precipitation upon dilution, suppressing efflux transporters, increasing both membrane permeability and lymphatic uptake. Nevertheless, despite the numerous advantages, the low loading efficiency, particularly for hydrophilic drugs, and the possible expulsion of drugs after polymeric transition during storage still pose considerable problems to scientists [127,128]. In spite of these drawbacks, their flexibility in preparation and the simplicity of large-scale production may encourage the widespread use of SLNs [129].…”

Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides

et al. 2019

View full text Add to dashboard Cite

Objectives The main objective of present review is to explore and evaluate the effectiveness of recently developed methods to improve the bioavailability of orally administered biopharmaceutical drugs. Methods A systematic search of sciencedirect, tandfonline and Google Scholar databases based on various sets of keywords was performed. All results were evaluated based on their abstracts, and irrelevant studies were neglected during further evaluation. Results At present, biopharmaceuticals are used as injectable therapies as they are not absorbed adequately from the different routes of drug administration, particularly the oral one. Their insufficient absorption is attributed to their high molecular weight, degradation by proteolytic enzymes, high hydrophilicity and rigidity of the absorptive tissues. From industrial aspect incorporation of enzyme inhibitors (EIs) and permeation enhancers (PEs) and mucoadhesive polymers into conventional dosage forms may be the easiest way of formulation of orally administered macromolecular drugs, but the effectiveness of protection and absorption enhancement here is the most questionable. Conjugation may be problematic from regulatory aspect. Encapsulation into lipid-based vesicles sufficiently protects the incorporated macromolecule and improves intestinal uptake but have considerable stability issues. In contrast, polymeric nanocarriers may provide good stability but provides lower internalization efficacy in comparison with the lipid-based carriers. Conclusion It can be concluded that the combination of the advantages of mucoadhesive polymeric and lid-based carriers in hybrid lipid/polymer nanoparticles may result in improved absorption and might represent a potential means for the oral administration of therapeutic proteins in the near future.

show abstract

Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery

Cited by 304 publications

References 170 publications

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Development and Statistical Optimization of Solid Lipid Nanoparticle Formulations of Fluticasone Propionate

Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides

Contact Info

Product

Resources

About