Lipid Nanoparticle-Based Inhibitors for SARS-CoV-2 Host Cell Infection
Vinith Yathindranath,
Nura Safa,
Mateusz Tomczyk
et al.
Abstract:Purpose
The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lingering threat to public health has fueled the search for effective therapeutics to treat SARS-CoV-2. This study aimed to develop lipid nanoparticle (LNP) inhibitors of SARS-CoV-2 entry to reduce viral infection in the nose and upper airway.
Methods
Two types of LNP formulations were prepared following a microfluidic mixing method. The LNP-Trap consisted of DOPC,… Show more
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