Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Souto, Eliana B.; Jäger, Eliézer; Jäger, Alessandro; Štěpánek, Petr; Cano, Amanda; Viseras, César; Barbosa, Raquel de Melo; Chorilli, Marlus; Zielińska, Aleksandra; Severino, Patrícia; Clares, Beatriz

doi:10.3390/nano12030377

Cited by 22 publications

(16 citation statements)

References 120 publications

(169 reference statements)

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“…Among them, lipid nanoparticles (e.g., solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, and oil-in-water (o/w) nanoemulsions) ( Figure 3 ) are particularly interesting, as they can be synthesized from lipid materials that comprise the skin (e.g., fatty acids; waxes; mono-, di-, and tri-glycerides; and phospholipids), offering great biocompatibility and biodegradability [ 55 , 56 , 57 ]. Lipid nanoparticles can also be surface-functionalized with aptamers for site-specific targeting [ 58 , 59 ] and show a modified-release profile [ 60 ], reducing the risk of toxicity ( Figure 4 ).…”

Section: Nanoparticle-related Therapies For Bccmentioning

confidence: 99%

Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles

Łasińska

Zielińska

Mackiewicz

et al. 2022

Cancers

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Skin cancer is the most common type of carcinoma diagnosed worldwide, with significant morbidity and mortality rates among Caucasians, in particular basal cell carcinoma (BCC). The main risk factors of BCC are well-identified, and there are many chemotherapeutic drugs available for its treatment. The effectiveness of therapeutic options is governed by several factors, including the location of the tumor, its size, and the presence of metastases (although rare for BCC). However, available treatments are based on non-targeted approaches, which encounter a significant risk of systemic toxicity in several organs. Site-specific chemotherapy for BCC has been proposed via the loading of anticancer drugs into nanoparticles. Among various types of nanoparticles, in this review, we focus on potential new regimens for the treatment of BCC using classical anticancer drugs loaded into novel lipid nanoparticles. To meet patient aesthetic expectations and enhance the effectiveness of basal cell carcinoma treatment, new therapeutic topical strategies are discussed, despite a limited number of reports available in the literature.

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Section: Nanoparticle-related Therapies For Bccmentioning

confidence: 99%

Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles

Łasińska

Zielińska

Mackiewicz

et al. 2022

Cancers

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“…There are two types of UV filters used for photoprotection. Dermatologists classified UV filters as inorganic and organic agents [ 2 ]. Organic filters absorb a narrow band of ultraviolet radiation (UVR), whereas for inorganic filters, the interaction of absorption and scattering results in “wide spectrum” (UVA and UVB) protection ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Strategies for Avobenzone: A Case Study of Photostabilization

et al. 2023

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Several developments and research methods are ongoing in drug technology and chemistry research to elicit effectiveness regarding the therapeutic activity of drugs along with photoprotection for their molecular integrity. The detrimental effect of UV light induces damaged cells and DNA, which leads to skin cancer and other phototoxic effects. The application of sunscreen shields to the skin is important, along with recommended UV filters. Avobenzone is widely used as a UVA filter for skin photoprotection in sunscreen formulations. However, keto-enol tautomerism propagates photodegradation into it, which further channelizes the phototoxic and photoirradiation effects, further limiting its use. Several approaches have been used to counter these issues, including encapsulation, antioxidants, photostabilizers, and quenchers. To seek the gold standard approach for photoprotection in photosensitive drugs, combinations of strategies have been implemented to identify effective and safe sunscreen agents. The stringent regulatory guidelines for sunscreen formulations, along with the availability of limited FDA-approved UV filters, have led many researchers to develop perfect photostabilization strategies for available photostable UV filters, such as avobenzone. From this perspective, the objective of the current review is to summarize the recent literature on drug delivery strategies implemented for the photostabilization of avobenzone that could be useful to frame industrially oriented potential strategies on a large scale to circumvent all possible photounstable issues of avobenzone.

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“…Consequently, the identification of commercially available cosmetics based on nanotechnology is quite challenging. Moreover, there is a recognized need for research into the efficacy and safety with precise guidelines for manufacturing, advertising, nanotoxicological testing, and safe use of nanocosmetics [ 27 , 28 , 33 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

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Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging

Cited by 22 publications

References 120 publications

Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles

Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles

Drug Delivery Strategies for Avobenzone: A Case Study of Photostabilization

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

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