Lipid nanocarriers: Formulation, properties, and applications

Rehman, Asad Ur; Akram, Salman; Seralin, Aidar; Vandamme, Thierry F.; Anton, Nicolas

doi:10.1016/b978-0-12-816770-0.00021-6

Cited by 14 publications

(9 citation statements)

References 126 publications

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“…FTIR spectra allow studying the length of lipid acyl chains, the degree of unsaturation of lipids, conformations of proteins and nucleic acids, the lipid/protein ratio, and so on which are particularly relevant spectral indicators for cancer diagnosis based on tissues and biofluids FTIR analysis [11]. The effectiveness of this technique was confirmed by its powerful discrimination of cancerous and healthy groups [12], identification of a degree of malignancy of breast cancer [13], and monitoring of the chemotherapy effectiveness applied in breast cancer treatment [14]. According to spectroscopic study of Elmi and co-workers [15] on the recognition of breast cancer, healthy and pathological serum samples have revealed their own characteristic spectra and spectral parameters.…”

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confidence: 99%

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

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Smęda

et al. 2019

Journal of Biophotonics

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Despite advanced diagnostic techniques used for detecting cancer, this disease still remains a leading cause of death in the developed world. What is more, the greatest danger for patients is not related with growing of tumor but rather with metastasis of cancer cells to the distant organs. In this study, Fourier transform infrared (FTIR) spectroscopy was used to track chemical changes in blood plasma to find spectral markers of metastatic breast cancer during the disease progression. Plasma samples were taken 1‐5 weeks after orthotropic inoculation of 4T1 metastatic breast cancer cells to mice. The earliest changes detected by FTIR spectroscopy in plasma were correlated with unsaturation of phospholipids and secondary structures of proteins that appeared 2 and 3 weeks, respectively, after 4T1 cells inoculation (micrometastatic phase). Significant alternations in the content and structure of lipids and carbohydrates were identified in plasma at the later stages (macrometastatic phase). When large primary tumors in breast and macrometastases in lung were developed, all bands in FTIR spectra significantly differed from those at earlier phases of the cancer progression. In conclusion, we showed that each phase of the breast cancer progression and its pulmonary metastasis can be characterized by a specific panel of spectral markers.

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mentioning

confidence: 99%

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Blat

Wiercigroch

Smęda

et al. 2019

Journal of Biophotonics

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“…To determine the bound protein concentration and hence, the binding capacity of nanocarriers, protein is titrated with increasing concentrations of nanoparticles associated with a 1 H signal intensity decrease. 103 Additionally, a 1D half-filter experiment can be used to evaluate the competitive binding of multiple isotopically enriched 13 C or 15 N-proteins to the nanoparticle surface. For instance, Wang et al used this approach to evaluate the apparent binding capacities of the AuNPs for two proteins (wild-type GB3 and ubiquitin) using an NMR measurement.…”

Section: Analytical Methods To Purify and Characterize Functionalized...mentioning

confidence: 99%

“…Thus, LBNCs have been developed for their special characteristics related to their structural properties and composition: a high drug-loading ability, high biocompatibility, and a tailorable surface to improve the targeting, biodistribution, and pharmacokinetic profile. 13 Table 1 summarizes the main functionalized LBNCs developed for biomedical applications during the last four years. Each example is given with particular emphasis on ligand type and goal, the functionalization method, and the drug and/ or cargo used function of the biomedical application.…”

Section: Functionalization Of Lipid-basedmentioning

confidence: 99%

“…However, in some cases the shell has both properties: it acts as a protective membrane that could also be used to entrap lipophilic drugs. Thus, LBNCs have been developed for their special characteristics related to their structural properties and composition: a high drug-loading ability, high biocompatibility, and a tailorable surface to improve the targeting, biodistribution, and pharmacokinetic profile …”

Section: Functionalization Of Lipid-based Nanocarriersmentioning

confidence: 99%

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Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based Nanocarriers

2020

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Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands has attracted huge interest in the field of nanomedicines for their ability to overcome some physiological barriers and their potential to deliver an active molecule to a specific target without causing damage to healthy tissues. The principal objective of this review is to summarize the present knowledge on LBNC decoration used for biomedical applications, with an emphasis on the ligands used, the functionalization approaches, and the purification methods after ligand corona formation. The most potent experimental techniques for the LBNC surface characterization are described. The potential of promising methods such as nuclear magnetic resonance spectroscopy and isothermal titration calorimetry to characterize ligand surface corona is also outlined.

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“…Base on size and lamellarity, liposomes can be classified into three types: multilamellar vesicles, small unilamellar vesicles, and large unilamellar vesicles. Liposomes are widely used as nanocarriers in drug delivery systems and provide a significant advantage due to their size, biocompatibility, biodegradable, low toxicity, and potential to encapsulate hydrophilic, lipophilic, and amphiphilic drugs [ 9 ]. Due to their physicochemical and biophysical properties, liposomes can deliver drugs at different concentrations [ 10 ].…”

Section: Organic Nanoparticlesmentioning

confidence: 99%

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

et al. 2021

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Ocular diseases can deteriorate vision to the point of blindness and thus can have a major impact on the daily life of an individual. Conventional therapies are unable to provide absolute therapy for all ocular diseases due to the several limitations during drug delivery across the blood-retinal barrier, making it a major clinical challenge. With recent developments, the vast number of publications undergird the need for nanotechnology-based drug delivery systems in treating ocular diseases. The tool of nanotechnology provides several essential advantages, including sustained drug release and specific tissue targeting. Additionally, comprehensive in vitro and in vivo studies have suggested a better uptake of nanoparticles across ocular barriers. Nanoparticles can overcome the blood-retinal barrier and consequently increase ocular penetration and improve the bioavailability of the drug. In this review, we aim to summarize the development of organic and inorganic nanoparticles for ophthalmic applications. We highlight the potential nanoformulations in clinical trials as well as the products that have become a commercial reality.

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Lipid nanocarriers: Formulation, properties, and applications

Cited by 14 publications

References 126 publications

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Relevant Physicochemical Methods to Functionalize, Purify, and Characterize Surface-Decorated Lipid-Based Nanocarriers

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

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