Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model

Abstract

Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the world. However, there are still no drugs for NAFLD/NASH in the market. Gastrodin (GAS) is a bioactive compound that is extracted from Gastrodia elata, which is used as an active compound on nervous system diseases. Recent reports showed that GAS and Gastrodia elata possess anti-oxidant activity and lipid regulating effects, which makes us curious to reveal the anti-NAFLD effect of GAS. A high cholesterol diet (HCD) was used to induce a NAFLD larval zebrafish model, and the lipid regulation and anti-oxidant effects were tested on the model. Furthermore, qRT-PCR studied the underlying mechanism of GAS. To conclude, this study revealed a lipid regulation and anti-oxidant insights of GAS on NAFLD larval zebrafish model and provided a potential therapeutic compound for NAFLD treatment.

Retracted: Gastrodin relieves inflammation injury induced by lipopolysaccharides in MRC‐5 cells by up‐regulation of miR‐103

“…Thereby, gastrodin has been considered as a potential therapeutic agent for diverse diseases such as Tourette syndrome, 7 myocardial infarction, 8 alcoholic liver disease 6,9 and acute lung injury. Thereby, gastrodin has been considered as a potential therapeutic agent for diverse diseases such as Tourette syndrome, 7 myocardial infarction, 8 alcoholic liver disease 6,9 and acute lung injury.…”

“…forth. Thereby, gastrodin has been considered as a potential therapeutic agent for diverse diseases such as Tourette syndrome, 7 myocardial infarction, 8 alcoholic liver disease 6,9 and acute lung injury. 10 However, the effects of gastrodin on COPD were not studied previously.…”

Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application

“…The Nrf2 activation mediated by herbal medicine can improve NAFLD via inhibiting oxidative stress pathway. It has been reported that scutellarin (a flavonoid glycoside), swertiamarin (a secoiridoid glycoside) (Yang Y. et al, 2019) and gastrodin (isolated from Gastrodia elata Bl) enhance Nrf2-mediated antioxidant system via activating the mRNA and protein levels of PPARg and its coactivator-1a, HO-1, GST, and NQO1 expressions (Ahmad et al, 2019), thus ameliorate NAFLD. Isochlorogenic acid B [extracted from Laggera alata (Asteraceae)] shows its protective effects on fibrosis in NASH by Nrf2 signaling pathway, and reverse the downregulation of miR-122 level and upregulation of hepatic HIF-1a expression to inhibit multiple profibrogenic factors (COL1a1, MCP-1, LOX, TGF-b1, and TIMP-1) (Liu et al, 2019c).…”

“…It has been indicated that herbal medicine has exerted the protective effects against the progression from hepatic steatosis to steatohepatitis and the underlying mechanism have been proved to be involved in inhibiting the inflammatory signaling pathway as shown in Figure 2, thereby regulating dyslipidemia and improving liver function in NAFLD. Many herbal medicine (including herbal formula, crude extract and pure bioactive compound form medicinal plants) possessed antiinflammatory properties for slowing down the NAFLD progression, such as Sinai san dection (Zhang et al, 2005), Hugan Qingzhi tablet (Tang et al, 2015), betulinic acid (Kim et al, 2019b), Alisma orientalis , gastrodin (Ahmad et al, 2019), the peel extract of Citrus aurantium L. (Rutaceae) (Han et al, 2019) and swertiamarin (Yang Y. et al, FIGURE 1 | The lipid mechanistic insight into the anti-NAFLD effects of herbal medicine. NAFLD, Non-alcoholic fatty liver disease.…”

A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix

“…It has the characteristics of multipathway and multitarget and can be used for holistic treatment from different levels because of its remarkable curative effect and small side effects [24][25][26]. More and more studies show that TCM is effective in treating NAFLD [27,28]. It is found that the extract of TCM or effective components can address not only NAFLD but also other illnesses of the metabolic syndrome, such as obesity, diabetes, and dyslipidemia.…”