Lipid-modified conjugated polymernanoparticles for cell imaging and transfection

Feng, Xuli; Tang, Yanli; Duan, Xinrui; Liu, Libing; Wang, Shu

doi:10.1039/b915112e

Cited by 146 publications

(165 citation statements)

References 27 publications

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“…The amplitude of the AC signal was 5 mV over the frequency range between 0.01 Hz and 100 kHz. 4 /C has well crystallized in orthorhombic structure as in the pristine sample, without any unexpected phases, such as Fe 2 P or Cr-containing compounds [18]. All diffraction peaks match well with the standard data for pure LiFePO 4 phase (PDF-40-1499).…”

Section: Electrochemical Measurementssupporting

confidence: 66%

Impact of incorporation of chromium on electrochemical properties of LiFePO4/C for Li-ion batteries

Naik

Zhou

Gao

et al. 2015

Materials Science-Poland

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LiFe 0.95 Cr 0.05 PO 4 /C was successfully synthesized by one-step solid-state reaction using a single mode microwave reactor. The effect of incorporation of chromium on LiFePO 4 lattice parameters was systematically investigated by X-ray diffraction. Surface analysis was done by scanning electron microscopy and transmission electron microscopy. The ratio of amorphous to graphitic carbon was determined from Raman spectroscopic data. The influence of chromium incorporation on electrochemical properties was studied by recording charge/discharge cycles combined with electrochemical impedance spectroscopy (EIS) and cyclic voltammetry. It was found that Cr incorporation significantly enhanced the electrochemical performance of LiFePO 4 at all current densities up to 10 C. LiFe 0.95 Cr 0.05 PO 4 /C prepared exhibited the best performance with an initial specific discharge capacity of 157.7, 144.8, 138.3, 131.0, 124.1 and 111.1 mAh·g −1 at 0.1 C, 0.5 C, 1.0 C, 2.0 C, 5 C and 10 C, respectively. The doped sample displayed excellent capacity retention, which was substantially superior than that of pristine LiFePO 4 /C at a higher current rate.

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Section: Electrochemical Measurementssupporting

confidence: 66%

Impact of incorporation of chromium on electrochemical properties of LiFePO4/C for Li-ion batteries

Naik

Zhou

Gao

et al. 2015

Materials Science-Poland

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“…The Shu Wang group (University of Chinese Academy of Science, China) has also shown interesting results regarding fluorescent conjugated polymer nanoparticles and their ability for cell imaging [25], [26]. In addition they have shown very interesting results with a conjugated polythiophene where the probe clearly can distinguish living and apoptotic cancer cells [27].…”

Section: Cpes As Fluorescent Reportersmentioning

confidence: 98%

Poly-and oligothiophenes : Optical probes for multimodal fluorescent assessment of biological processes

Magnusson¹

2015

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IICover: Fibroblasts and melanoma cells stained with a fluorescent thiophene probe called p-HTIm, DAPI and antibodies against ER, proteasomes, α-tubulin, fibronectin, or mitotracker against mitochondria.During the course of the research underlying this thesis, Karin Magnusson was enrolled in Forum Scientium, a multidisciplinary doctoral program at Linköping University, Sweden. ABSTRACTOne interesting class of molecules in the research field of imaging biological processes is luminescent conjugated polythiophenes, LCPs. These fluorescent probes have a flexible backbone consisting of repetitive thiophene units. Due to this backbone, the probes possess unique abilities to give rise to different spectral signatures depending on their target and environment. LCPs are a polydispersed material meaning there is an uneven distribution of lengths of the probe. Recently, monodispersed chemically well-defined material denoted luminescent conjugated oligothiophenes, LCOs, with an exact number of repetitive units and distinct sidechain functionalities along the backbone has been developed. LCOs have the advantages of being smaller which leads to higher ability to cross the blood brain barrier. The synthesis of minor chemical alterations is also more simplified due to the well-defined materials. During my doctoral studies I have used both LCPs and LCOs to study biological processes such as conformational variation of protein aggregates in prion diseases and cellular uptake in normal cells and cancer cells. The research has generally been based on the probes capability to emit light upon irradiation and the interaction with their targets has mainly been assessed through variations in fluorescence intensity, emission-and excitation profiles and fluorescence lifetime decay. These studies verified the utility of LCPs and LCOs for staining and discrimination of both prion strains and cell phenotypes. The results also demonstrated the pronounced influence minor chemical modifications have on the LCO´s staining capacity. IV POPULÄRVETENSKAPLIG SAMMANFATTNING LYSANDE MOLEKYLER FÖR STUDIER AV BIOLOGISKA PROCESSERLuminiscenta konjugerade polytiofener, LCPs, är en väldigt intressant typ av molekyl som kan användas för att studera processer i biologiska system. Strukturen hos dessa fluorescerande molekyler kan liknas vid olika element som är fästa vid en ryggrad. De olika elementen ger molekylen dess affinitet för sin målmolekyl, medan ryggraden är mest ansvarig för molekylens optiska egenskaper. Ryggraden ändrar sin struktur beroende på målmolekylen och resultatet kan avläsas med ett flertal fluorescens-metoder. Längden på ryggraden hos LCPs varierar och varje parti av en LCP består därmed av en blandning längder och storlekar. De senaste åren har Peter Nilssons forskargrupp utvecklat LCPs till molekyler med väldefinierad längd på ryggraden som då betecknas luminiscenta konjugerade oligotiofener, LCOs. Dessa mindre molekyler har större möjlighet att passera blodhjärnbarriären samt att syntesen för små kemiska modifieringar av elementen ...

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“…Amphiphilic and hydrophilic semiconducting polymer nanoparticles have also been explored for gene delivery. Lipid-modified cationic poly(fluorenylene phenylene) polymer (PFPL) with ammonium pendant groups was synthesized and bound to DNA through electrostatic interactions [29]. The pCX-EGFP plasmid encoding the green fluorescent protein (GFP) was associated with the PFPL nanoparticles to form a nanoparticle/plasmid complex that was taken up by A549 cells through endocytosis.…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

“…Reproduced with permission from Ref. [27,29]. Fluorescent CPNs have also been designed to deliver small interfering RNA (siRNA) [30].…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

Highly Luminescent Conjugated Polymer Nanoparticles for Imaging and Therapy

2013

Can Chem Trans

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Lipid-modified conjugated polymernanoparticles for cell imaging and transfection

Cited by 146 publications

References 27 publications

Impact of incorporation of chromium on electrochemical properties of LiFePO4/C for Li-ion batteries

Impact of incorporation of chromium on electrochemical properties of LiFePO4/C for Li-ion batteries

Poly-and oligothiophenes : Optical probes for multimodal fluorescent assessment of biological processes

Highly Luminescent Conjugated Polymer Nanoparticles for Imaging and Therapy

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