Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period

Turk, Romana; Podpečan, Ožbalt; Mrkun, Janko; Kosec, M.; Flegar-Meštrić, Zlata; Perkov, Sonja; Starič, Jože; Robić, Mirna; Belić, Maja; Zrimšek, Petra

doi:10.1016/j.anireprosci.2013.07.014

Cited by 38 publications

(51 citation statements)

References 35 publications

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“…The lowest HDL concentration as well as depleted cholesterol levels at that time are due to lipomobilisation syndrome occuring around the transition period (Mazur et al 1988, Grummer 1993. Our data seems to confirm previous observations made by Turk et al (2013Turk et al ( , 2004 concerning postpartum PON1 activity decrease in Holstein-Friesian cows. Furthermore we noted a similar pattern occuring in Polish Red and Norwegian breeds.…”

Section: Discussionsupporting

confidence: 91%

“…Interestingly, Turk et al (2013) demonstrated lowered PON1 activity and total antioxidative status (TAS) concentrations a week before labour, but only a PON1 significant decrease after calving, indicating that PON1 could be a better parameter for oxidative stress and negative energy balance than TAS (there were also no significant differences in postpartum TAS levels in our examined breeds -data unpublished).…”

Section: Discussionmentioning

confidence: 78%

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Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Kulka¹,

Kołodziejska-Lesisz²,

Kluciński³

2016

Polish Journal of Veterinary Sciences

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We investigated the measurement of paraoxonase 1 (PON1), as a potential marker of redox state changes in dairy cows, its involvement in lipid metabolism and compared it with superoxide dismutase (SOD) activity changes. We also evaluated lipid metabolism parameters associated with dairy production. PON1 paraoxonase and arylesterase acitvities, SOD activity, beta-hydroxybutyrate (BHB), uric acid (UA), high density lipoprotein (HDL), low density lipoprotein (LDL), cholesterol and triglyceride concentrations were measured in Holstein-Friesian, Polish Red and Norwegian breeds serum in two production cycles. Our data showed a significant postpartum depletion in PON1 activity and lipoprotein and lipid products concentrations, with elevated BHB values. However, there were no significant changes in SOD activity and uric acid concentrations in Holstein-Friesian and Polish Red breeds after calving. At lactation peak there was a significant SOD activity decrease correlated with standardized PON1 activity depletion in all examined breeds. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 78%

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Kulka¹,

Kołodziejska-Lesisz²,

Kluciński³

2016

Polish Journal of Veterinary Sciences

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“…Different methods are reported to measure lipoproteins in cows (Feingold et al, 1998;Kushibiki et al, 2002) but usually they require ultracentrifugation of the samples which is not routinely performed in veterinary diagnostic laboratories. Most of the literature concerning lipoprotein changes in cows deals with the transition period, while little is known about possible changes of lipoproteins in newborn calves (Turk et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…A C C E P T E D M A N U S C R I P T 5 oxidation during transition period (Ileri-Büyükoğlu et al, 1998;Kurpinska et al, 2015;Newman et al, 2016;Turk et al, 2013). In contrast, very few information is reported about lipoprotein changes in newborn calves (Herosimczyk et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Giordano

Rossi

Probo

et al. 2017

Research in Veterinary Science

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T 2 AbstractHigh density lipoproteins (HDLs) are pivotal in innate immunity and decrease in serum during inflammation. Several studies have been done about lipoprotein changes in transition cows but little is known about their changes in newborn calves. The aim of this study is to provide information about HDLs in newborn calves, by defining the possible age-related changes in healthy calves compared with adults and by assessing the possible differences in calves with inflammation.Lipoprotein electrophoretic separation (reported as percentages) and colorimetric measurement of HDL (HDL-C) were performed on healthy cows and calves in order to identify possible differences in the lipoprotein profile due to the age. Then, age-matched calves with inflammatory conditions were also evaluated. Results showed that in calves HDL% and VLDL% were lower (mean values ± SD: 77.6% ± 8.6% and 2.6% ± 2.5%, respectively) and LDL% was higher (19.7% ± 7.4%) than in adults (89.0% ± 3.9%; 5.2 ± 2.1% and 5.8% ± 3.1%, respectively). Sick calves revealed a decrease of both HDL% (mean values ± SD: 61.0% ± 22.1%) and HDL-C (22.8 ± 11.6 mg/dL) and an increase of VLDL% (12.1% ±13.1%) compared with controls (77.6% ± 8.6%; 41.5 ± 11.2 mg/dL and 2.6% ± 2.5%, respectively). Paraoxonase-1 activity, influenced by inflammation and oxidation, was measured, and it appeared correlated with HDL% and HDL-C in sick calves. In conclusion, this study revealed that HDLs concentration in healthy calves is lower than in adults, and further decreases in calves with inflammation, likely due to oxidation.. Keywords:High density lipoproteins; Calf; Inflammation; Paraoxonase-1; Electrophoresis. ACCEPTED MANUSCRIPTA C C E P T E D M A N U S C R I P T 3 Highlights: Electrophoretic and colorimetric lipoprotein measurement were performed in calves  Good correlation between the two methods was found  Healthy calves showed lower HDL% and VLDL% and higher LDL% compared to adult cows  HDL decreases early during inflammation in sick calves  PON-1 activity was positively correlated with HDL-C in both sick and healthy calves ACCEPTED MANUSCRIPT

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“…In a similar study, Mohebbi-Fani et al (2012) found that vitamins with antioxidant capacity (such as vitamin A, E, and C) decrease from the beginning of gestation; so early gestation involves a reduction in antioxidant capacity. Although there is no record of antioxidant capacity during the first few days of gestation, other researchers have found that it decreases a few days before parturition (Turk et al, 2013). Lipid oxidation generally follows the same trend as antioxidant capacity, tending to decrease as gestation advances, suggesting that decrease in antioxidant capacity is due to the fact that antioxidants were used to decrease lipid oxidation.…”

Section: Oxidative Statusmentioning

confidence: 95%

Oxidative status and fertility of ewes supplemented coffee pulp during estrous synchronization and early pregnancy

Salinas-Rios

Sánchez-Torres

Dı́az-Cruz

et al. 2016

Rev Colomb Cienc Pecu

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Oxidative status and fertility of ewes supplemented coffee pulp during estrous synchronization and early pregnancy ¤ Estado oxidativo y fertilidad en ovejas suplementadas con pulpa de café durante la sincronización estral y gestación tempranaEstado oxidativo e fertilidade nas ovelhas suplementadas com a polpa de café durante sincronização do estro e gestação inicial SummaryBackground: it is known that coffee pulp can modify the oxidative status and fertility in dairy cows. Objective: to evaluate the effect of dietary supplementation with coffee pulp on the antioxidant capacity, lipid oxidation and reproductive characteristics of ewes during estrous synchronization and early gestation. Methods: forty Dorset-Suffolk crossbred ewes with 3 or 4 parturitions were allocated to two treatments: T0 (n = 21), ewes supplemented with 450 g of a control feed; and T1 (n = 19), ewes supplemented with 450 g of the feed with 25% coffee pulp. Supplementation began 14 days before estrous synchronization and ended 25 days after breeding. During estrous synchronization, progestogen (CIDR, Controlled Internal Drug Release) ¤ To cite this article: Salinas T, Sánchez MT, Dìaz A, Cordero JL, Càrdenas M, Hernàndez J, Nava C, Nieto R. Oxidative status and fertility of ewes supplemented coffee pulp during estrous synchronization and early pregnancy. Rev Colomb Cienc Pecu 2016; 29:255-263.

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Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period

Cited by 38 publications

References 35 publications

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Serum paraoxonase 1 (PON1) activity and lipid metabolism parameters changes in different production cycle periods of Holstein-Friesian, Polish Red and Norwegian breeds

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Oxidative status and fertility of ewes supplemented coffee pulp during estrous synchronization and early pregnancy

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